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Circular No. 10 2015 TT-BKHDT of the Ministry of Planning and Investment on plan for contractor selection tài liệu, giáo...
Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by the dysregulated expression of many proinflammatory cytokines including tumour necrosis factor α (TNF-α), with increased yet insufficient production of anti-inflammatory cytokines including IL-10 [1]. The vali- dation of TNF-α as a therapeutic target in RA has encour- aged the investigation of signalling pathways regulating its production by cells relevant to the pathophysiology of this disease. One pathway known to downregulate proinflam- matory TNF-α production and, consequently, upregulate the anti-inflammatory cytokine IL-10 is that elicited by the second messenger cAMP [2,3]. This pathway may there- fore represent a good therapeutic target due to its oppos- ing effects on TNF-α and IL-10. Previously, we and others demonstrated that rolipram, a phosphodiesterase (PDE) IV inhibitor, reduced the clinical and histological severity of collagen-induced arthritis (CIA) [4,5]. These studies APC = antigen-presenting cell; ATF-1 = activating transcription factor-1; CIA = collagen-induced arthritis; CREB = cAMP response element binding protein; ELISA = enzyme-linked immunosorbent assay; FCS = fetal calf serum; IC 50 = median inhibitory concentration; IFN = interferon; IL = interleukin; LPS = lipopolysaccharide; M-CSF = macrophage-colony stimulating factor; NF-κB = nuclear factor κB; PBMC = peripheral blood mononuclear cells; PDE = phosphodiesterase; PKA = protein kinase A; PKC = protein kinase C; PMA = phorbol 12-myristate 13-acetate; RA = rheumatoid arthritis; RA-SMC = rheumatoid arthritis synovial membrane cell; RPMI = Roswell Park Memorial Institute [medium]; Th1/Th2 = T helper cell type 1/2; TNF-α = tumour necrosis factor α; VIP = vasoactive intestinal peptide. Available online http://arthritis-research.com/content/5/6/R317 Research article Impact of VIP and cAMP on the regulation of TNF- αα and IL-10 production: implications for rheumatoid arthritis Andrew D Foey 1 , Sarah Field 1 , Salman Ahmed 1 , Abhilash Jain 2 , Marc Feldmann 1 , Fionula M Brennan 1 and Richard Williams 1 1 Kennedy Institute of Rheumatology Division, Charing Cross Hospital Campus, Imperial College School of Medicine, London, UK 2 Department of Musculoskeletal Surgery, Charing Cross Hospital Campus, Imperial College School of Medicine, London, UK Corresponding author: Andrew D Foey (a.foey@ic.ac.uk) Received: 14 Mar 2003 Revisions requested: 24 Apr 2003 Revisions received: 8 Aug 2003 Accepted: 11 Aug 2003 Published: 3 Sep 2003 Arthritis Res Ther 2003, 5:R317-R328 (DOI 10.1186/ar999) © 2003 Foey et al., licensee BioMed Central Ltd (Print ISSN 1478-6354; Online ISSN 1478-6362). This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Abstract Vasoactive intestinal peptide (VIP) is an anti-inflammatory immunomodulatory neuropeptide with therapeutic potential demonstrated for collagen-induced arthritis. The aim of this study was to characterise its potential anti-arthritic effect on human monocytes, macrophages, T cells, and rheumatoid arthritis synovial membrane cells. Monocytes, macrophages, and T cells derived from human peripheral blood were treated with VIP and compared with other cAMP-elevating drugs for a range of activating stimuli. Cytokine production was assessed for cell cultures and, in addition, the ability of VIPs to activate cAMP response element binding protein. VIP partially suppressed monocyte- and macrophage-derived tumour necrosis factor α (TNF-α) with no effect on IL-10, whereas VIP fails to regulate IL-10 and TNF-α production by T lymphocytes. No such modulation of cytokine profile was observed for rheumatoid arthritis synovial membrane cells. Elevation of intracellular cAMP, on the other hand, potently suppressed macrophage TNF-α production and modulated T- cell response by inhibiting TNF-α and IFN-γ. Công ty Luật Minh Gia www.luatminhgia.com.vn THE MINISTRY OF PLANNING AND INVESTMENT Circular No 10/2015/TT-BKHDT dated October 26, 2015 of the Ministry of Planning and Investment on plan for contractor selection Pursuant to the Law on Bidding No 43/2013/QH13 dated November 26, 2013; Pursuant to the Government's Decree No 63/2014/NĐ-CP dated June 26, 2014 on guidelines for some Articles on contractor selection of the Law on Bidding; Pursuant to the Government's Decree No 116/2008/NĐ-CP dated November 14, 2008 on defining the functions, tasks, powers and organizational structure of the Ministry of Planning and Investment; The Minister of Planning and Investment promulgates a Circular to provide guidelines for planning contractor selection Article Scope of adjustment This Circular provides specific guidance on making, submitting, appraising, approving contractor selection plans with regard to the procurements and projects regulated by the Law on Bidding No 43/2013/QH13, except for drug procurement prescribed in Clause Article of the Law on Bidding Article Subject of application This Circular applies to agencies, organizations participating in making, submitting, appraising, approving contractor selection plans with regard to the procurements and projects mentioned in Article of this Circular, and relevant entities Article The application of this Circular In case an international agreement contains regulations on contractor selection procedures, Clause and Clause Article of the Law on Bidding shall apply Procedures for submitting, appraising, and approving the contractor selection plan shall comply with this Circular In case an international agreement does not contain regulations on contractor selection procedures, the contractor selection plan shall be made, submitted, appraised, and approved in accordance with this Circular For procurements executed before a decision on project approval, the following adjustments must be made when applying this Circular: a) If the investor is determined, the phrase “investor” will be replaced with “Units directly under investor”; “authorized people” with “the leader of LUẬT SƯ TƯ VẤN PHÁP LUẬT 24/7: 1900 6169 Công ty Luật Minh Gia www.luatminhgia.com.vn investors”; “Decision approving the project” with “Decision of approval from the leader of investors”; b) If the investor is not determined, the phrase “investor” will be replaced with “Units appointed to prepare the project”; “authorized people” with “unit’s leaders appointed to prepare the project”; “Decision to approve the project” with “Relevant Decisions from unit’s leaders appointed to prepare the project” With regard to procurements funded by state budget prescribed in Point d Clause Article of the Law on Bidding, this Circular must be applied when making, submitting, appraising, and approving contractor selection plans, except for the contents prescribed by the Circular on use of state budget for regular operation promulgated by the Ministry of Finance When applying this Circular, the phrase “Investor” will be replaced with “procuring entity”; “project” with “procuring estimation” Article Application for contractor selection plan approval The rules for making the contractor selection plan are specified in Article 33 of the Law on Bidding The basis for making the contractor selection plan is specified in Article 34 of the Law on Bidding The application for contractor selection plan approval is made according to Form enclosed herewith, which contains: a) Completed tasks including tasks related to preparation of project and procurements to be completed first with corresponding values and legal basis; b) Tasks that not apply any contractor selection method include: operation of project management board, provision of compensation for land clearance, loan interest payment, tasks performed by the investor including making, appraising the request for expression of interest, pre-qualification documents, bidding documents, request for proposals; assessing expressions of interest, prequalification applications , bid-envelopes, proposals; appraising the contractor selection result, and other tasks that not apply contractor selection with corresponding values; c) The tasks that require the contractor selection must specify the quantity of procurements, content of each procurement, according to Article of this Circular, and explanation for such contents This part must specify the basis for dividing the project into smaller procurements It is prohibited to divide the project into procurements against regulations of the Law on Bidding for the purpose of direct contracting or restricting participation of bidders Provision of LUẬT SƯ TƯ VẤN PHÁP LUẬT 24/7: 1900 6169 Công ty Luật Minh Gia www.luatminhgia.com.vn explanation for procurements competitive bidding and all-inclusive contracts is not required; d) If there are tasks that not require contractor selection (if any), contents and values of such tasks must be specified dd) Total ...BioMed Central Page 1 of 10 (page number not for citation purposes) Radiation Oncology Open Access Research No supra-additive effects of goserelin and radiotherapy on clonogenic survival of prostate carcinoma cells in vitro Robert M Hermann* 1 , Dag Schwarten 1 , Stefanie Fister 2 , Carsten Grundker 2 , Margret Rave-Frank 1 , Mirko Nitsche 1 , Andrea Hille 1 , Paul Thelen 3 , Heinz Schmidberger 4 and Hans Christiansen 1 Address: 1 Department of Radiotherapy, University hospital, Robert-Koch-Str. 40, 37075 Göttingen, Germany, 2 Department of Gynecology, University hospital Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany, 3 Department of Urology, University hospital Göttingen, Robert- Koch-Str. 40, 37075 Göttingen, Germany and 4 Department of Radiotherapy, University hospital, Langenbeckstr. 1, 55131 Mainz, Germany Email: Robert M Hermann* - ro.hermann@t-online.de; Dag Schwarten - djschwarten@web.de; Stefanie Fister - sfister@gwdg.de; Carsten Grundker - grundker@med.uni-goettingen.de; Margret Rave-Frank - mfraenk@med.uni-goettingen.de; Mirko Nitsche - mnitsche@med.uni-goettingen.de; Andrea Hille - a.hille@med.uni-goettingen.de; Paul Thelen - pthelen@gwdg.de; Heinz Schmidberger - H.Schmidberger@klinik.uni-mainz.de; Hans Christiansen - hans.christiansen@medizin.uni-goettingen.de * Corresponding author Abstract Background: Oncological results of radiotherapy for locally advanced prostate cancer (PC) are significantly improved by simultaneous application of LHRH analoga (e.g. goserelin). As 85% of PC express LHRH receptors, we investigated the interaction of goserelin incubation with radiotherapy under androgen-deprived conditions in vitro. Methods: LNCaP and PC-3 cells were stained for LHRH receptors. Downstream the LHRH receptor, changes in protein expression of c-fos, phosphorylated p38 and phosphorylated ERK1/2 were analyzed by means of Western blotting after incubation with goserelin and irradiation with 4 Gy. Both cell lines were incubated with different concentrations of goserelin in hormone-free medium. 12 h later cells were irradiated (0 – 4 Gy) and after 12 h goserelin was withdrawn. Endpoints were clonogenic survival and cell viability (12 h, 36 h and 60 h after irradiation). Results: Both tested cell lines expressed LHRH-receptors. Changes in protein expression demonstrated the functional activity of goserelin in the tested cell lines. Neither in LNCaP nor in PC-3 any significant effects of additional goserelin incubation on clonogenic survival or cell viability for all tested concentrations in comparison to radiation alone were seen. Conclusion: The clinically observed increase in tumor control after combination of goserelin with radiotherapy in PC cannot be attributed to an increase in radiosensitivity of PC cells by goserelin in vitro. Background Luteinising hormone releasing hormone (LHRH) analoga play an important role in the treatment of prostate carci- noma (PC). As an alternative to surgical castration to sup- press testosterone levels they are used in the palliative treatment of advanced disease. Furthermore, in locally Published: 26 August 2007 Radiation Oncology 2007, 2:31 doi:10.1186/1748-717X-2-31 Received: 24 May 2007 Accepted: 26 August 2007 This article is available from: http://www.ro-journal.com/content/2/1/31 © 2007 Hermann et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Radiation Oncology 2007, 2:31 http://www.ro-journal.com/content/2/1/31 Page 2 of 10 (page number not for citation purposes) advanced disease they improve overall survival when given simultaneously to curative radiotherapy [1-3]. The mechanism of this enhancement of survival is still obscure. Interestingly, several older trials that compared radiotherapy CATEGORY PART 1: INTRODUCTION (Page 1) I Reason for choosing the topic (Page 1) II The objectives of the topic ( page 2) III The object of the topic (page 2) IV The research methods (page 2) PART 2: DEVELOPMENT 2.1 Theoretical base of experience initiative (page 2) (page 2) 2.2 The actual status of teaching and learning vocabulary at Lam Kinh high schools (page 3) 2.3 Solutions and implementation (page 5) 2.4: The efficiency of the experience initiative (page 17) PART 3: CONCLUSIONS AND RECOMMENDATIONS (page 19) I.Conclusions (page 19) II Recommendations REFERENCES APPENDIX: EXPERIMENTAL TESTS (page 19) PART 1: INTRODUCTION I Reason for choosing the topic: Theoretically: - English is the language of globalization It's not only the language of international business and politics but also the primary language used for most computers and for the inner workings of the Internet English is the dominant international language in communications, science, aviation, entertainment, radio and diplomacy English is an important tool for operating on the world stage The ability to speak and understand English is mandatory in certain fields, professions, and occupations - In the era of the development of science and technology and of acculturation, they require each of us to basic knowledge and certain skills In particular, foreign language skill, especially English, is the key for us to open the important door to step out in the world Besides the skills of listening, speaking, reading and writing, the vocabulary is very necessary for a foreign language learner Vocabulary is also a very important platform for students to complete their skills in the learning of English in secondary schools However, in practice, the vocabulary is not easy so students often encounter many difficulties One of the difficulties of the students is absorbing and memorizing vocabulary that they have learned or once used before Practically: Along with the development of society and the need to reach out to the world, the English teaching methods and course content is constantly being renewed and improved The English mateiral for grade 10 with a lot of different topics gives students more knowledge about life and diverse society However, the diversity of subjects and requires students to memorize more vocabulary This is a major barrier for the students, especially for those in rural and mountainous areas Therefore, how to find the most effective way of teaching vocabulary to help students understand each lesson easier is the responsibility of every foreign language teacher Nowadays, there are many good methods of teaching vocabulary, but the selection and the application of those methods in a flexible way for each unit is not easy for each teacher In the process of teaching vocabulary to students at the school, I and some of my colleagues in the team faced many difficulties in finding I 107 TH CONGRESS 1 ST S ESSION H. R. 1784 To establish an Office on Women’s Health within the Department of Health and Human Services, and for other purposes. IN THE HOUSE OF REPRESENTATIVES M AY 9, 2001 Mrs. M ORELLA (for herself, Mrs. M ALONEY of New York, Mr. W AXMAN , Mr. T OM D AVIS of Virginia, Ms. S LAUGHTER , Mr. M C N ULTY , Mr. H ONDA , Ms. B ROWN of Florida, Mrs. T HURMAN , Ms. E SHOO , Mr. L ANTOS , Ms. L EE , Mr. W YNN , Mr. F ROST , Ms. N ORTON , Ms. M C C ARTHY of Missouri, Mr. H ILLIARD , Mr. H ORN , Ms. B ALDWIN , Ms. M ILLENDER -M C D ONALD , Mrs. C HRISTENSEN , Ms. D E L AURO , Ms. J ACKSON -L EE of Texas, Mr. W EXLER , Ms. S OLIS , Mrs. R OUKEMA , Mr. K ILDEE , Ms. K APTUR , Ms. H ARMAN , Ms. S CHAKOWSKY , Mr. B ENTSEN , and Mrs. J ONES of Ohio) in- troduced the following bill; which was referred to the Committee on En- ergy and Commerce A BILL To establish an Office on Women’s Health within the Depart- ment of Health and Human Services, and for other pur- poses. Be it enacted by the Senate and House of Representa-1 tives of the United States of America in Congress assembled,2 SECTION 1. SHORT TITLE.3 This Act may be cited as the ‘‘Women’s Health Office4 Act of 2001’’.5 2 •HR 1784 IH SEC. 2. HEALTH AND HUMAN SERVICES OFFICE ON WOM-1 EN’S HEALTH.2 Part A of title II of the Public Health Service Act3 (42 U.S.C. 202 et seq.) is amended by adding at the end4 the following:5 ‘‘SEC. 229. HEALTH AND HUMAN SERVICES OFFICE ON6 WOMEN’S HEALTH.7 ‘‘(a) E STABLISHMENT OF O FFICE .—There is estab-8 lished within the Office of the Secretary an Office on9 Women’s Health (referred to in this section as the ‘Of-10 fice’). The Office on Women’s Health shall be headed by11 a Deputy Assistant Secretary for Women’s Health.12 ‘‘(b) D UTIES .—The Office shall, with respect to the13 health concerns of women—14 ‘‘(1) establish short-range and long-range goals15 and objectives and coordinate all activities within the16 Department of Health and Human Services that re-17 late to disease prevention, health promotion, service18 delivery, research, and public and health care profes-19 sional education concerning women;20 ‘‘(2) provide expert advice and consultation to21 the Secretary concerning scientific, legal ethical, and22 policy issues relating to women’s health;23 ‘‘(3) monitor the Department of Health and24 Human Services offices, agencies, and regional ac-25 tivities regarding women’s health and stimulate ac-26 3 •HR 1784 IH tivities and facilitate coordination of such depart-1 mental and agency offices on women’s health;2 ‘‘(4) establish a Department of Health and3 Human Services Coordinating Committee on Wom-4 en’s Health to be chaired by the Deputy Assistant5 Secretary for Women’s Health which shall be com-6 posed of senior level representatives from each of the7 agencies and offices of the Department of Health8 and Human Services;9 ‘‘(5) establish a National Women’s Health In-10 formation Center to—11 ‘‘(A) facilitate the exchange of information12 regarding matters relating to health Hai duong’s people committee THE SOCIALIST REPUBLIC OF VIET NAM DEPARTMENT OF PLANNING & INVESTMENT Independence - Freedom Happiness Hai Duong, December 21th, 2012 No: 1606/BC-KHDT-KTDN REPORT ON HAI DUONG’S FDI OF THE YEAR 2012 AND PLANNING OF THE YEAR 2013 Investment Certificate granting: 1.1 Investment Certificate granting and adjusting: a) Investment Certificate granting: Up to now (31/12/2012), Hai Duong province has 241 valid projects with total investment capital of 5.665,14 million USD (in which there are 115 projects inside Industrial Zones with total investment capital of 1.882,6 million USD; there are 126 projects outside Industrial Zones with total investment capital of 3.779,54 million USD) In 2012, granted Investment Certificate for 20 newly projects with total investment capital of 52,11 million USD (in which 08 projects inside Industrial Zones with total investment capital of 24,26 million USD; 12 projects outside Industrial Zones I 107 TH CONGRESS 1 ST S ESSION H. R. 1784 To establish an Office on Women’s Health within the Department of Health and Human Services, and for other purposes. IN THE HOUSE OF REPRESENTATIVES M AY 9, 2001 Mrs. M ORELLA (for herself, Mrs. M ALONEY of New York, Mr. W AXMAN , Mr. T OM D AVIS of Virginia, Ms. S LAUGHTER , Mr. M C N ULTY , Mr. H ONDA , Ms. B ROWN of Florida, Mrs. T HURMAN , Ms. E SHOO , Mr. L ANTOS , Ms. L EE , Mr. W YNN , Mr. F ROST , Ms. N ORTON , Ms. M C C ARTHY of Missouri, Mr. H ILLIARD , Mr. H ORN , Ms. B ALDWIN , Ms. M ILLENDER -M C D ONALD , Mrs. C HRISTENSEN , Ms. D E L AURO , Ms. J ACKSON -L EE of Texas, Mr. W EXLER , Ms. S OLIS , Mrs. R OUKEMA , Mr. K ILDEE , Ms. K APTUR , Ms. H ARMAN , Ms. S CHAKOWSKY , Mr. B ENTSEN , and Mrs. J ONES of Ohio) in- troduced the following bill; which was referred to the Committee on En- ergy and Commerce A BILL To establish an Office on Women’s Health within the Depart- ment of Health and Human Services, and for other pur- poses. Be it enacted by the Senate and House of Representa-1 tives of the United States of America in Congress assembled,2 SECTION 1. SHORT TITLE.3 This Act may be cited as the ‘‘Women’s Health Office4 Act of 2001’’.5 2 •HR 1784 IH SEC. 2. HEALTH AND HUMAN SERVICES OFFICE ON WOM-1 EN’S HEALTH.2 Part A of title II of the Public Health Service Act3 (42 U.S.C. 202 et seq.) is amended by adding at the end4 the following:5 ‘‘SEC. 229. HEALTH AND HUMAN SERVICES OFFICE ON6 WOMEN’S HEALTH.7 ‘‘(a) E STABLISHMENT OF O FFICE .—There is estab-8 lished within the Office of the Secretary an Office on9 Women’s Health (referred to in this section as the ‘Of-10 fice’). The Office on Women’s Health shall be headed by11 a Deputy Assistant Secretary for Women’s Health.12 ‘‘(b) D UTIES .—The Office shall, with respect to the13 health concerns of women—14 ‘‘(1) establish short-range and long-range goals15 and objectives and coordinate all activities within the16 Department of Health and Human Services that re-17 late to disease prevention, health promotion, service18 delivery, research, and public and health care profes-19 sional education concerning women;20 ‘‘(2) provide expert advice and consultation to21 the Secretary concerning scientific, legal ethical, and22 policy issues relating to women’s health;23 ‘‘(3) monitor the Department of Health and24 Human Services offices, agencies, and regional ac-25 tivities regarding women’s health and stimulate ac-26 3 •HR 1784 IH tivities and facilitate coordination of such depart-1 mental and agency offices on women’s health;2 ‘‘(4) establish a Department of Health and3 Human Services Coordinating Committee on Wom-4 en’s Health to be chaired by the Deputy Assistant5 Secretary for Women’s Health which shall be com-6 posed of senior level representatives from each of the7 agencies and offices of the Department of Health8 and Human Services;9 ‘‘(5) establish a National Women’s Health In-10 formation Center to—11 ‘‘(A) facilitate the exchange of information12 regarding matters relating to health HAI DUONG'S FDI IN THE FIRST QUARTER OF THE YEAR 2013 (Up to 31/03/2013) No 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Investors Malaysia Japan Hong Kong Taiwan Samoa Korea The United State China Thailand Bristish Virgin Island Germany Denmark Singapore England Brunei Australia Canada Holland Mauritus France Russia Sec Senegan Number of projetcs 48 20 43 11 52 Total Investment capital 2263.208 851.862 680.062 617.062 355.669 313.702 Fixed capital 453.17 261.923 115.08 177.912 139.129 153.375 24 166.4 136.676 69.006 88 64.886 59.856 1 1 247 40.896 40.05 34 30.946 22.9 17.375 6.48 5.936 4.271 1.85 1.75 1.088 5.693,700 21.962 40.05 3.00 4.246 7.05 7.045 2.894 5.936 0.6 1.367 0.95 1.75 0.6 1.525,742 TOP 20 PROVINCES, CITIES ATTRACTED THE LARGEST FDI (Up to 31/3/2013) No Provinces, cities Ho Chi Minh city Ba Ria - Vung Tau Number of projects Total registration Capital (USD) Fixed Capital 4401 32,463,778,815 11,885,947,360 287 26,297,964,396 ... Application for contractor selection plan approval The rules for making the contractor selection plan are specified in Article 33 of the Law on Bidding The basis for making the contractor selection plan. .. making the contractor selection plan and notes (if any) c) Contents of the application for contractor selection plan approval: - The contents mentioned in Clause Article of this Circular, conformity... appraise the contractor selection plan Appraisal of the contractor selection plan involves inspection, evaluation, and provision of opinions according to regulations of law on bidding and relevant