MINISTER OF EDUCATION UNIVERSITY OF ECONOMICS HO CHI MINH CITY MINH HAI, PHAN PREFERENCES FOR SEASONAL INFLUENZA VACCINE FOR WORKING ADULTS IN HO CHI MINH CITY: A DISCRETE CHOICE EXPERIMENT THESIS FOR MASTER OF HEALTH ECONOMIC MANAGEMENT Ho Chi Minh, City – 2015 MINISTER OF EDUCATION UNIVERSITY OF ECONOMICS HO CHI MINH CITY MINH HAI, PHAN PREFERENCES FOR SEASONAL INFLUENZA VACCINE FOR WORKING ADULT IN HO CHI MINH CITY: A DISCRETE CHOICE EXPERIMENT Faculty: Development Economic Code: 60310105 THESIS FOR MASTER OF HEALTH ECONOMIC MANAGEMENT INSTRUCTOR: DR DANG THUY, TRUONG Ho Chi Minh, City – 2015 ABSTRACT Introduction: Seasonal influenza is viral infection which affects 5%–10% in adults and 20%–30% in children, and the influenza vaccine, also known as flu shot, is an annual vaccination using a vaccine that is specific for a given year There is increasing interest in benefit of vaccination coverage in health working adults which reduced work loss From 2005, the vaccine manufacturing capacity are increasing globally and especially in Viet Nam, that would support in price and number of doses in broadening the vaccination We conduct the study to assess the influencing factors for vaccination in working adults and how to increase the vaccination in population via the willingness to pay model Method: We conducted a discrete choice experiment, a quantitative approach which often used in health economic studies In which, the questionnaire with socio-economic and discrete choice experiment questions was collected for 172 respondents The conditional logit model was used to estimate the relative importance of influenza vaccine attributes: effectiveness (50%, 70%, 90%); adverse event (0%, 5%,10%), time of vaccination process (45 minutes, 60 minutes, 90 minutes); place of vaccination (working place, healthcare center); cost (150,000 VND 200,000 VND 250,000 VND and 300,000 VND) Based on the utility functions, the willingness to pay and potential vaccination coverage was estimated for different vaccine scenarios and price support strategy Result: The results indicated the effectiveness and adverse event are two valuable influence (p valueVND 400,000 400,000  1: Hoàn toàn không nh h ng  3: Không có ý ki n  4: nh h b t c giá n u t t c n thi t) ng đ n quy t đ nh ch n tiêm phòng v c xin cúm c a b n? M c đ t ng d n t đ n  2: Ít nh h ch p nh n ng nhi u  5: Ch c ch n nh h ng ng M c đ quan tr ng/ nh h Các y u t Ph n ng ph c a tiêm ch ng - Ph n ng t i ch Ph n ng t i ch (S ng, đ , đau), m c đ nh , không nh h ng đ n sinh ho t, k t thúc vòng ngày Th ng x y (10-64%) - Ph n ng toàn thân (s t, nh c đ u, m t m i, viêm h ng, s m i, ngh t m i) Ít x y - Ph n ng nghiêm tr ng đòi h i ph i can thi p y khoa tích c c ho c nh p vi n (t l r t th p: ph n tri u) Hi u qu c a Vaccine vi c gi m nguy c m c b nh cúm Bi t v vi c có vaccine ng a cúm Nguy c lây cho ng i xung quanh (Ng i thân, đ ng nghi p…) S thu n ti n th i gian tiêm ch ng Giá c a vaccine cúm Th i m d ch cúm t ng T l tr n ng c a b nh cúm (nh p vi n) kho ng 8% Th i gian ngh vi c b nh liên quan đ n cúm ho c t ng t cúm S t v n c a b n bè Y ut nh h ng khác (vui lòng li t kê) ng APPENDIX (Questionnarie#1: Survey for the factors of influenza vaccination) Note: the questionnaire was remained as local language as originally, to avoid any confusion maybe caused by translation B ng kh o sát y u t nh h ng đ n quy t đ nh ch n tiêm phòng v c xin cúm B n tham gia vào kh o sát v nhu c u tiêm phòng v c xin cúm mùa c a ng i dân Vi t Nam đ tu i lao đ ng tin cá nhân c a b n s đ ây b ng kh o sát n danh, v y thông c gi kín t đ i, ch s d ng ý ki n c a b n vào m c đích nghiên c u B ng vi c hoàn thành b ng kh o sát này, b n đ ng ý v i nh ng thông tin R t c m n s h p tác c a b n Trân tr ng c m n! I Thông tin cá nhân: Tu i (tính theo n m):……… Gi i tính Nam N Trình đ h c v n Trung h c c s (c p 2) Ph thông trung h c (c p 3) Trung c p/cao đ ng Sau đ i h c ih c T ng s n m h c: … L nh v c ho t đ ng c a công ty b n công tác: L nh v c s c kh e / y t L nh v c khác Thu nh p hàng tháng (tri u đ ng) [...]... preferences for vaccine cost 6 Discrete choice experiment application in seasonal influenza vaccine Shono A and Kondo M have used the DCE to investigate the parent’s preferences for seasonal influenza vaccine for their children in Japan In Japan, trivalent inactivated influenza vaccine which administrated by hypodermic injection, and children under 13 years of age, and new live-attenuated influenza vaccine. .. policy-makers information to assess the alternatives 1.1 Introduction of Influenza Seasonal influenza infection Influenza is a viral infection (including influenza A and influenza B strains) that affects mainly the nose, throat, bronchi and, occasionally, lungs Infection usually lasts for about a week, and is characterized by sudden onset of high fever, aching muscles, headache and severe malaise, non-productive... 0.02%GDP) in Thailand The percentage of total cost for productivity losses (indirect cost) was more than 80% in European countries (except Spain), 38% in US, 12.5% in Hong Kong and 55.3% in Thailand 1.3 Influenza vaccination The influenza vaccine, also known as flu shot, is an annual vaccination using a vaccine that is specific for a given year to protect against the highly variable influenza virus (Couch,... of any age with certain medical conditions) are vulnerable to the complications of influenza that cause the hospitalizations, deaths and high healthcare costs Meanwhile, in health working adult group, the major impact of influenza is related to work absenteeism, impaired working performance and daily activities Influenza prevalence (WHO, 2013) The Global Influenza Surveillance and Response System (GISRS)... collect the choice from respondents for influenza vaccination Discrete choice experiment was chosen as the approach of stated preference which is advantage in evaluating the different features of vaccination Chapter 2 provide the overview of customer theory, random utility maximization (RUM) and the literature review Chapter 3 describes choice discrete choice experiment and the design of survey Chapter 4... appear with equal frequency with each level of each other attribute in all the included alternatives), level balance (the levels of each attribute in appear with equal frequency in all the included alternatives), minimal overlap (there are as few overlaps of levels as possible for each attribute in each choice set) and utility balance (the options in each choice set should have 15 similar probabilities... 2008) Generally, the influenza vaccines included the common trivalent strains (mixture of Influenza A (H1N1; H3N2) and influenza B strains) were produced into two kinds of form: the trivalent inactivated influenza vaccine (TIV) and the live attenuated influenza vaccine (LAIV) In Viet Nam, the TIV is the most popular and being circulated in market, so the data of TIV was used for model The antigenic... was no significant preference for injection avoided (nasal spray versus injection) For interaction between “opt-out” option and attributes and demographic, it shows the older and women are more likely to prefer no vaccination 20 The willingness to pay for an improvement in an attribute of seasonal influenza vaccination Table 3: Willingness to pay for influenza vaccine in Japan Scenario/feature WTP (yen)... which is administrated by a thimerosal-free nasal spray Seasonal influenza vaccine for children is voluntary The refined list of attributes and levels: Table 2: Attributes and levels of influenza vaccine in Japan Attributes Level Vaccination price for one winter 0; 2000 yen; 3500 yen; 5000 yen season 6500 yen; 8000 yen; 10,000 yen Times of vaccination for one winter One time season Two time 19 Vaccine. .. vaccination rate is low for Southeast Asia including Viet Nam, with less than 1% vaccination in total population The vaccine manufacturing program is expected to supply 500 millions of influenza vaccine in 2016, which is enough to cover the vaccination for all Southeast Asia countries 2 This thesis is to answer how to increase the vaccination rate in working adults to provide the policy-makers information ... set Choice set_2 Choice set_3 Choice set_4 Choice set_1 Group of choice set Choice set_2 Choice set_3 Choice set_4 Choice set_1 Group of choice set Choice set_2 Choice set_3 Choice set_4 Vaccine. .. investigate the parent’s preferences for seasonal influenza vaccine for their children in Japan In Japan, trivalent inactivated influenza vaccine which administrated by hypodermic injection, and children... 13 years of age, and new live-attenuated influenza vaccine which is administrated by a thimerosal-free nasal spray Seasonal influenza vaccine for children is voluntary The refined list of attributes