Appendices Spectral data for Chapter 2.5060 2.5000 2.4940 3.6708 6.0780 ju211017.2 O OH H3 N O 2.0000 9.6 9.2 8.8 8.4 8.0 7.6 7.2 6.8 6.4 6.0 1.8314 2.10a Integral O COOH 5.6 5.2 4.8 (ppm) 4.4 4.0 3.6 3.2 2.8 2.4 2.0 1.6 1.2 0.8 0.4 0.0 191 40.8364 40.5528 40.2764 40.0000 39.7236 39.4473 39.1636 135.5091 169.5540 167.6849 ju201013.2 O OH H3 N O O 190 180 COOH 2.10a 170 160 150 140 130 120 110 100 (ppm) 90 80 70 60 50 40 30 20 10 192 2.5882 2.5657 2.5427 2.5121 2.5060 2.5000 2.4940 3.0183 2.9953 2.9728 6.0462 ju231019.3 O OH H3 N O 9.6 9.2 8.8 8.4 8.0 7.6 7.2 6.8 6.4 6.0 5.6 5.2 4.8 (ppm) 4.4 4.0 3.6 3.2 2.0408 2.1143 2.10b 2.0000 Integral O COOH 2.8 2.4 2.0 1.6 1.2 0.8 0.4 0.0 193 190 180 170 160 150 140 OH H3 N O O 130 120 110 (ppm) 100 90 80 70 60 50 40 32.0070 40.8291 40.5455 40.2691 40.0000 39.7164 39.4400 39.1636 35.3598 136.5346 167.8594 172.4923 ju231019.4 O COOH 2.10b 30 20 10 194 9.6 9.2 8.8 8.4 8.0 7.6 7.2 6.8 6.4 6.0 O 5.6 5.2 (ppm) 4.8 4.4 4.0 3.6 3.2 2.8 2.4 2.1062 OH H3 N O 2.1068 2.1584 2.0000 Integral 2.0 1.6 -0.0015 -0.0026 1.7922 1.7675 1.7423 1.7171 1.6930 2.8358 2.8112 2.7854 2.5055 2.5000 2.4940 2.3515 2.3269 2.3028 3.3262 6.0112 fe10shy1.1 (1091) O COOH 2.10c 1.2 0.8 0.4 0.0 195 23.0248 30.9233 40.5527 40.2764 40.0000 39.7236 39.4400 38.8363 136.6291 167.8594 174.2670 ju261091.2 O OH H3 N O O 190 180 170 160 150 140 130 120 110 100 (ppm) COOH 2.10c 90 80 70 60 50 40 30 20 10 196 2.5049 2.5000 2.4945 3.6127 3.8696 3.8505 6.0331 8.6787 8.6600 8.6409 fe10shy3.1 (1095) O H N OH H3N O COOH O 9.6 9.2 8.8 8.4 8.0 7.6 7.2 6.8 6.4 6.0 5.6 5.2 4.8 (ppm) 4.4 4.0 1.9943 2.2256 2.10d 2.0000 1.1746 Integral O 3.6 3.2 2.8 2.4 2.0 1.6 1.2 0.8 0.4 0.0 197 41.2510 40.8291 40.5527 40.2764 40.0000 39.7164 39.4400 39.1563 136.6001 171.3214 167.8012 166.8776 fe10shy3.2 (1095 13C) O H N OH H3N O COOH O O 190 180 170 160 150 140 130 120 110 2.10d 100 (ppm) 90 80 70 60 50 40 30 20 10 198 9.6 9.2 8.8 8.4 8.0 7.6 7.2 6.8 6.4 6.0 5.6 5.2 (ppm) 4.8 4.4 4.0 3.6 3.2 2.8 2.4 2.0 1.6 1.2 1.1899 4.2532 1.1166 O 2.2068 OH O 2.1416 1.0972 2.0000 Integral 1.2884 1.2622 1.2392 1.2122 1.1820 1.0882 1.0580 1.8732 1.6976 1.5840 1.5530 2.5000 2.9568 2.9465 6.0441 ja302131.1 (2-131) O H 3N 2.10e 0.8 0.4 0.0 199 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 2.0 1.5 6.6346 9.6107 3.6776 3.4429 3.2659 0.9003 2.6517 2.0143 1.7534 O 0.9087 O 0.9644 HN 0.7988 3.0927 0.7295 2.0000 1.9391 0.6985 0.7570 0.7757 Integral OHCHN O O N N N O 7.22g 1.0 0.5 349 8.1469 7.8619 7.6098 7.3917 7.3753 7.2606 7.1559 7.1383 5.8006 5.7843 5.2018 5.1690 5.1350 5.1022 5.0858 5.0757 5.0682 5.0593 4.5399 4.5324 4.5197 4.5034 4.4958 4.3042 4.2966 4.2878 4.2789 4.2714 3.2666 3.2590 3.2515 3.2426 3.2363 3.2288 2.8518 2.8455 2.8291 2.6312 2.6160 2.6009 2.5858 2.2063 2.2025 2.1950 2.1887 2.1735 2.1584 2.1420 2.0903 2.0828 2.0739 2.0525 2.0437 1.9668 1.9617 1.9567 1.7991 1.7663 1.7499 1.2519 1.2179 1.2028 1.1876 0.9569 0.9443 0.9317 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 2.0 1.5 6.7669 3.9142 3.5715 6.2496 0.9426 6.9601 2.0245 O 1.0616 O 2.0473 1.1590 HN 0.9845 3.2326 0.8625 3.0 (ppm) 2.0000 2.2624 0.8502 0.9412 0.9020 Integral 3.2 2.8 OHCHN O O N O N N 7.22h O 1.0 0.5 350 2.8645 2.8518 2.8455 2.8292 3.2565 3.2502 3.2414 3.2351 3.2263 8.1469 7.8103 7.6124 7.3816 7.3627 7.2606 6.8471 6.8282 5.8234 5.8083 5.1943 5.1615 5.1489 5.1275 5.0947 5.0833 5.0745 5.0644 5.0569 4.5412 4.5337 4.5223 4.5059 4.4971 4.3004 4.2929 4.2840 4.2752 4.2676 4.0205 4.0067 3.9928 3.9789 3.2654 3.2565 3.2502 3.2414 3.2351 3.2263 2.8645 2.8518 2.8455 2.8292 2.2076 2.2026 2.1900 2.1711 2.1547 2.1131 2.0904 2.0815 2.0740 2.0513 1.9681 1.9630 1.9567 1.7979 1.7487 1.6668 1.6554 1.6428 1.4083 1.3944 1.3806 1.2532 0.9595 0.9456 0.9343 8.8 8.4 8.0 7.6 7.2 6.8 6.4 6.0 5.6 5.2 4.8 (ppm) 4.4 4.0 3.6 3.2 2.8 2.4 0.8 2.0 O 1.6 7.0609 O 6.0461 O 20.093 1.0090 HN 5.8007 1.6993 1.0 1.0000 1.2 2.9569 1.4 1.0190 1.6 0.8770 1.8 1.0043 2.0 1.8576 2.2 0.8129 1.8828 1.7151 0.9386 0.8365 0.9462 Integral 0.9620 0.9494 0.9368 1.2558 1.6403 1.5558 1.5445 1.5331 1.9656 1.9605 2.0917 2.2076 2.2026 1.2 0.9620 0.9494 0.9368 1.6403 1.5558 1.5445 1.5331 1.2558 2.2076 2.2026 2.0917 1.9656 1.9605 2.8645 3.2503 3.7835 4.2954 4.5211 5.0720 5.1968 5.9054 6.8572 6.8396 7.2606 7.4144 7.3968 8.1595 8.0259 7.7145 7.7069 7.7032 7.6956 7.6792 1H AMX500 mh6009db OHCHN O O N N N 7.22i (ppm) MeO 0.8 0.4 351 9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 2.0 1.5 6.8701 2.9800 7.5821 0.5921 5.3317 1.8692 O 1.0000 O 0.9506 O 0.8594 0.9630 HN 2.2298 0.7512 2.5735 1.5835 2.2436 0.6747 0.6831 Integral OHCHN O O N N N 7.22j 1.0 0.5 352 3.2124 3.2049 3.1973 2.8809 2.2291 2.2152 2.2013 2.1837 2.1786 2.1698 2.1547 2.1383 2.1106 2.0942 2.0740 2.0652 2.0576 1.9580 1.9530 1.9479 1.2583 1.2558 1.1095 0.9305 0.9179 0.9040 4.5110 4.4870 4.2475 4.2387 4.2311 5.0392 5.6393 5.6255 5.3557 5.3229 5.3040 5.2989 5.2712 8.4331 8.1154 7.9238 7.9087 7.8683 7.8532 7.7385 7.7195 7.7032 7.5456 7.5342 7.5166 7.5002 7.4926 7.4775 7.4661 7.4611 7.2606 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 2.0 1.5 6.6064 16.135 O 2.1934 2.7098 0.9693 O 0.8457 0.7674 2.0950 1.0197 HN S O O 1.9592 1.0794 1.0583 1.2573 1.2405 MeO 1.1520 0.8502 1.0168 2.0000 2.2606 0.7995 Integral OHCHN O O N N N 7.22k 1.0 0.5 353 2.1900 2.0702 1.9631 1.9580 1.9530 1.4399 1.4247 1.4121 1.3213 1.3087 1.2860 1.2734 1.2596 1.2570 1.0036 0.9910 0.9721 0.9595 2.8935 2.7813 3.2112 3.2049 3.8516 4.7858 4.5917 4.5715 4.4732 4.4505 4.3496 4.2336 4.2223 4.2172 4.2046 5.9205 5.9028 7.2606 7.0652 7.0488 6.9568 6.9392 7.6994 7.6817 8.3839 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) HN S O O 4.0 3.5 3.0 4.5 (ppm) 2.5 4.4 2.0 4.3 1.5 6.0000 O 4.6 7.4265 O 4.7 3.7159 4.8 10.077 4.9 0.9339 2.1781 4.1125 0.9167 6.0 1.9928 1.7634 1.0074 6.4 0.9186 6.8 0.8996 0.9544 0.9731 1.0329 0.9046 7.2 (ppm) 0.7862 7.6 0.8319 8.0 1.7596 8.4 1.6882 0.7972 0.8600 Integral 4.3194 4.3105 4.3017 4.2929 4.2828 4.2172 4.2097 4.2009 4.1920 4.1845 4.4845 4.4770 4.4555 4.4492 4.4354 4.4278 4.6169 4.6068 4.5967 4.5904 4.5803 4.5703 4.8073 4.7921 4.7858 4.7707 5.9835 5.9697 7.0400 7.0236 7.3338 7.3161 7.2606 7.6855 7.6679 7.5859 8.3802 4.5904 4.5803 4.5703 4.4845 4.4770 4.4555 4.4492 4.4354 4.4278 4.3194 4.3105 4.3017 4.2929 4.2828 4.2172 4.2097 4.2009 4.1920 4.1845 3.2251 3.2162 3.2087 3.2011 3.1935 3.1860 3.0296 3.0208 3.0107 3.0019 2.9704 2.9565 2.9427 2.9288 2.8784 2.8695 2.8582 2.8494 2.7977 2.7838 2.7737 2.3072 2.1850 2.1799 2.1686 2.1345 2.1181 2.0513 2.0425 2.0374 1.9568 1.9517 1.9467 1.7777 1.7639 1.7525 1.7160 1.7071 1.6895 1.6794 1.6718 1.6592 1.5117 1.4991 1.4865 1.2621 1.2495 0.9986 0.9860 0.9709 0.9583 1H AMX500 mh0825_6015b 4.2 1.0 4.1 OHCHN O O N N N 7.22l 0.5 354 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 NH S O O 4.5 (ppm) 4.0 3.5 O 3.0 2.5 2.0 1.5 3.2615 3.8905 O 8.2868 4.2 13.109 5.9909 (ppm) 1.0000 1.2505 2.0645 1.1612 2.0389 1.8851 2.8088 5.6385 1.0566 1.0565 1.0816 1.2314 1.4429 0.9688 4.4 0.7732 4.6 0.8498 4.8 3.5326 1.7545 0.8031 0.8384 Integral OHCHN O O N N N 7.22m 1.0 0.5 355 4.3131 4.2866 4.2211 4.2160 4.2034 4.1933 4.1832 4.7859 4.6157 4.6068 4.5955 4.5791 4.5690 4.4783 4.4581 4.4366 7.6729 7.6565 7.5935 7.2846 7.2682 7.2607 7.0287 7.0123 5.9672 5.9520 4.7859 4.6157 4.6068 4.5955 4.5791 4.5690 4.4783 4.4581 4.4366 4.3131 4.2866 4.2211 4.2160 4.2034 4.1933 4.1832 3.2226 3.2074 3.1999 2.9994 2.8620 2.7876 2.6489 2.6338 2.6187 2.3211 2.1850 2.1699 2.0425 1.9593 1.9543 1.7084 1.6908 1.6820 1.6719 1.6567 1.6416 1.6265 1.5155 1.5029 1.4916 1.4802 1.2558 0.9999 0.9873 0.9722 0.9583 0.9432 0.9293 0.9217 0.8801 8.3802 9.5 9.0 8.5 8.0 7.5 7.0 6.5 6.0 5.5 6.0 HN S O O 5.0 (ppm) 4.5 4.8 O O 4.0 3.5 4.6 3.0 4.4 (ppm) 2.5 2.0 1.5 6.3446 6.4 1.0684 6.5139 0.7378 5.4053 5.5213 4.3604 6.8 0.9074 0.9027 1.8729 1.0750 7.2 (ppm) 0.9338 0.9751 1.0238 1.0669 0.9019 0.8287 7.6 0.8704 8.0 0.9451 2.0768 0.7669 3.0538 1.0000 0.7809 Integral 8.4 4.2 4.0 OHCHN O O N N N 7.22n 1.0 0.5 356 4.3105 4.3017 4.2929 4.2828 4.2740 4.2652 4.1681 4.1605 4.1530 4.1429 4.1353 4.7846 4.7682 4.7631 4.7455 4.6421 4.6333 4.6207 4.6156 4.6043 4.5967 4.4757 4.4681 4.4543 4.4480 4.4404 4.4265 4.4190 6.1663 6.1512 8.4130 8.3613 7.9515 7.9351 7.9263 7.9099 7.8961 7.8797 7.7107 7.7069 7.6931 7.6893 7.6565 7.6452 7.6300 7.6263 7.6212 7.6187 7.6048 7.5910 7.5746 7.2594 7.0425 7.0262 4.6333 4.6207 4.6156 4.6043 4.5967 4.4757 4.4681 4.4543 4.4480 4.4404 4.4265 4.4190 4.3105 4.3017 4.2929 4.2828 4.2740 4.2652 4.1681 4.1605 4.1530 4.1429 4.1353 3.2061 3.1973 3.1910 3.1822 3.1759 3.1671 3.1065 3.0965 3.0839 3.0738 3.0649 3.0549 3.0435 3.0334 2.8594 2.8481 2.8393 2.8040 2.7914 2.7813 2.2871 2.2795 2.2732 2.2656 2.2593 2.1295 2.1257 2.1207 2.1156 2.1131 2.0816 2.0425 2.0274 2.0211 2.0148 1.9984 1.9908 1.9845 1.9379 1.9328 1.9265 1.8055 1.7903 1.7803 1.7677 1.7588 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 2.0 1.5 10.012 N N 8.9516 O 3.5180 2.9829 4.0547 1.7088 11.731 O 2.1882 4.3 1.0901 4.4 0.9132 4.5 3.2710 4.7 4.6 (ppm) 1.0000 4.8 2.1280 4.9 0.6669 5.0 0.8594 0.8558 Integral 5.1 4.2 OHCHN O O N 7.22o 1.0 0.5 357 4.3433 4.3319 4.3269 4.3143 4.3042 4.2966 4.2891 4.6534 4.6446 4.6345 4.6269 4.6169 4.6093 5.0720 5.0581 5.0442 7.3526 7.2606 6.0440 6.0289 5.0720 5.0581 5.0442 4.6534 4.6446 4.6345 4.6269 4.6169 4.6093 4.3433 4.3319 4.3269 4.3143 4.3042 4.2966 4.2891 3.7533 3.7406 3.7293 3.2590 3.2439 3.2364 3.2300 3.2212 2.8178 2.8027 2.7875 2.7737 2.7636 2.7472 2.7321 2.7169 2.7018 2.2089 2.2038 2.1849 2.1685 2.1546 2.0891 2.0815 2.0727 2.0588 1.9630 1.9592 1.6945 1.6730 1.6554 1.5886 1.5659 1.5482 0.9771 0.9721 0.9658 0.9607 0.9469 8.2314 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 2.0 1.5 6.5548 1.3828 3.6089 5.0393 11.827 9.3603 O 1.5084 N N 1.0000 O 0.9723 1.1710 1.4815 1.4109 0.6427 0.7557 0.7256 0.8609 Integral OHCHN O O N 7.22p 1.0 0.5 358 5.9860 5.4112 5.0657 4.9333 4.9182 4.8980 4.6509 4.3408 4.3332 4.3131 4.3042 4.2967 3.2667 3.2591 3.2528 3.2452 3.2377 3.2301 2.8103 2.7939 2.7800 2.7611 2.7434 2.7283 2.7145 2.2114 2.1976 2.1812 2.1686 2.1496 2.1370 2.1219 2.1043 2.0942 2.0765 2.0639 2.0437 1.9668 1.9618 1.9568 1.8042 1.7790 1.6807 1.5659 0.9784 0.9683 7.3111 7.3060 7.2606 8.2264 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 2.0 6.3276 1.7 5.9024 N N N 1.9 1.8 (ppm) 4.1774 O 2.0 5.3115 1.0318 0.8445 O 2.1 2.0618 OH 2.2 1.0146 2.3 0.8818 7.2 0.9441 7.6 (ppm) 0.8476 8.0 0.9780 0.9206 0.8904 0.9611 1.0000 0.8070 0.7988 Integral (ppm) 1.6 1.5 1.4 OHCHN O O 7.22q 1.5 1.0 0.5 359 0.7271 1.7185 1.7072 1.6958 1.6908 1.6202 1.5786 1.5609 1.5521 1.5471 1.5420 1.5294 1.7576 1.8080 1.9530 1.9480 1.9429 2.2077 2.1989 2.1938 2.1825 2.1585 2.1447 2.1308 2.1081 2.0993 2.0917 2.0778 2.0690 2.0615 7.4309 7.4284 7.4145 7.4120 7.2973 7.2834 7.2657 7.2607 7.1901 7.1800 7.1636 7.0035 6.9884 6.9720 8.0234 8.2453 9.9082 7.0035 6.9884 6.9720 5.9584 5.1112 5.0960 5.0872 5.0771 5.0607 4.6296 4.6207 4.6106 4.6043 4.5943 4.5854 4.3295 4.3207 4.3131 4.3043 4.2955 3.2692 3.2604 3.2541 3.2453 3.2390 3.2301 2.9641 2.9503 2.9339 2.9200 2.9074 2.8998 2.8847 2.8696 2.8545 2.2291 2.2127 2.2077 2.1989 2.1938 2.1825 2.1585 2.1447 2.1308 2.1081 2.0993 2.0917 2.0778 2.0690 2.0615 1.9530 1.9480 1.9429 1.8080 1.7576 1.7185 1.7072 1.6958 1.6908 1.6202 1.5786 1.5609 1.5521 1.5471 1.5420 1.5294 0.9873 0.9747 0.9621 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 2.0 1.5 6.8723 4.9332 4.9932 N N 6.9429 0.9761 Br O 2.1683 O 1.1194 5.0 (ppm) 0.9944 5.5 1.0546 6.0 0.9171 0.8450 4.1693 0.9030 1.0000 Integral 8.0 7.5 (ppm) 4.5 OHCHN O O N 7.22r 1.0 0.5 360 4.6333 4.6257 4.6157 4.6094 4.5980 4.5904 4.3232 4.3143 4.3055 4.2980 4.2891 5.0935 5.0834 5.0771 5.0683 5.0594 5.0531 5.0430 5.9344 5.9193 7.6364 7.8734 8.2428 4.6157 4.6094 4.5980 4.5904 4.3232 4.3143 4.3055 4.2980 4.2891 3.2654 3.2566 3.2503 3.2415 3.2352 3.2263 2.9326 2.9200 2.9036 2.8897 2.8759 2.8569 2.8418 2.8267 2.8116 2.2001 2.1951 2.1913 2.1888 2.1825 2.1749 2.1585 2.1446 2.1408 2.1345 2.1282 2.1119 2.1068 2.0980 2.0892 2.0766 2.0677 2.0602 2.0400 1.9555 1.9505 1.9454 1.8194 1.8068 1.7954 1.7916 1.7815 1.7727 1.7652 1.7563 1.7488 1.7374 1.7185 1.7084 1.6971 1.6920 1.6744 1.5924 1.5571 1.5534 1.5433 1.5294 0.9873 0.9747 0.9633 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 O 4.5 (ppm) 4.0 3.5 3.0 2.5 2.0 6.1362 O 4.6204 N N N 1.6 5.0995 0.9324 0.8843 4.2792 O2 N 1.8 2.0094 2.0 (ppm) 1.0000 2.2 0.8240 2.4 0.7517 8.0 0.7622 8.2 (ppm) 0.8921 1.9078 0.7442 0.7315 1.6593 Integral 8.4 1.4 OHCHN O O 7.22s 1.5 1.0 0.5 361 1.7298 1.7260 1.7184 1.7071 1.7008 1.5722 1.5571 1.5470 1.5369 1.5243 1.9529 1.9466 1.9416 2.1950 2.1899 2.1824 2.1660 2.1597 2.1483 2.1420 2.1307 2.1017 2.0941 2.0853 2.0714 2.0639 2.0550 8.0057 7.9880 8.0864 8.2629 8.4041 8.3864 7.9880 7.2606 5.9192 5.0644 5.0556 5.0468 5.0392 5.0304 5.0228 5.0140 4.5967 4.5891 4.5727 4.5614 4.5538 4.3168 4.3092 4.3004 4.2916 4.2828 3.2742 3.2603 3.2515 3.2452 3.2364 3.2300 3.2212 2.9678 2.9565 2.9388 2.9262 2.9161 2.9023 2.8859 2.8720 2.8556 2.2089 2.2026 2.1950 2.1899 2.1824 2.1660 2.1597 2.1483 2.1420 2.1307 2.1017 2.0941 2.0853 2.0714 2.0639 2.0550 1.9529 1.9466 1.9416 1.7298 1.7260 1.7184 1.7071 1.7008 1.5722 1.5571 1.5470 1.5369 1.5243 0.9948 0.9822 0.9759 0.9633 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 0.9295 2.2562 2.2400 2.1443 3.1331 O 1.0323 1.0928 0.8893 1.0000 2.2221 3.2056 Integral S CF OMe O S-MTPA ester 2.0 1.5 1.0 0.5 362 3.5383 2.4251 2.4125 2.3999 2.2902 2.2852 2.2738 2.2700 2.2625 2.2562 2.2511 2.2398 2.2347 2.2284 2.2234 2.2171 2.2120 2.2020 2.1969 2.1830 2.1780 2.1679 2.1629 1.9259 1.9107 1.8969 1.8817 1.8704 1.8653 1.8540 1.8489 1.8389 1.8263 1.8200 1.8099 7.5411 7.5336 7.5260 7.4113 7.4062 7.3987 7.2600 5.6929 5.6790 5.6740 5.6639 5.6589 5.6437 5.6387 5.6337 5.6286 5.6236 5.6097 5.2983 5.2870 5.2819 5.2769 5.2718 5.2655 5.2605 5.2491 5.0701 5.0625 5.0386 8.5 8.0 7.5 7.0 6.5 6.0 5.5 5.0 4.5 (ppm) 4.0 3.5 3.0 2.5 1.0860 1.0163 1.0742 2.1996 O 2.1068 7.5 7.4 (ppm) 3.1417 1.0402 1.0858 0.9567 7.6 1.0000 2.0843 3.0657 Integral R OMe CF O R-MTPA ester 2.0 1.5 1.0 0.5 363 7.4062 7.4025 7.3962 7.3924 7.5525 7.5449 7.5374 3.5673 3.5648 2.4844 2.4818 2.4705 2.4579 2.1540 2.1490 2.1402 2.1377 2.1276 2.1213 2.1150 2.1061 2.1036 2.0948 2.0885 2.0355 2.0305 2.0204 2.0154 2.0053 2.0002 1.9864 1.9813 1.9662 1.9612 1.9561 1.8401 1.8376 1.8263 1.8225 1.8124 1.8061 1.7998 1.7960 7.5374 7.4062 7.4025 7.3962 7.3924 7.2600 5.8076 5.7938 5.7887 5.7849 5.7786 5.7749 5.7711 5.7610 5.7572 5.7534 5.7459 5.7433 5.7383 5.7244 5.3260 5.3147 5.3021 5.2996 5.2882 5.2769 5.1495 5.1470 5.1369 5.1142 ... 125.7577890 MHz DATE_d : DECNUC : off NS 39.9955 39.8279 39.7551 39.6968 39.6603 39.4927 39.3324 39.1648 38.9972 38.8514 38.7057 BF1 : 137 Oct 23 2006 NUCLEUS : off PULPROG : zgpg30 SFO1 : 125.7709936... Parameters *** O sg1023~1 : *** Acquisition Parameters *** O 2.19 Oct 23 2006 : off NS O : DECNUC N : 125.7577890 MHz DATE_d : 57 off PULPROG : N H BF1 NUCLEUS : N H (1) N O : PROCNO 34.0345 33.9106 O... MHz 1.00 Hz 32768 *** 1D NMR Plot Parameters *** O N H (1) 35.0 : SF 60 50 40 30 20 10 60.62 Hz off 220 39.6968 38.8514 38.7057 38.4506 34.0345 33.9106 69.5313 69.4875 68.9774 68.9556 97.4419