Appendix X-ray Data 418 Appendix Crystal data and structure refinement for 2-1 Identification code 8309 Empirical formula C45 H33 Cl3 O12 Formula weight 872.06 Temperature 223(2) K Wavelength 0.71073 Å Crystal system Triclinic Space group Pī Unit cell dimensions a = 10.9989(12) Å α= 112.139(2)°. b = 13.8100(14) Å β= 90.723(3)°. c = 14.2340(15) Å γ = 94.576(3)°. Å3 Volume 1994.1(4) Z Density (calculated) 1.452 Mg/m3 Absorption coefficient 0.297 mm-1 F(000) 900 Crystal size 0.16 x 0.10 x 0.08 mm3 Theta range for data collection 1.55 to 27.49°. Index ranges -14[...]... PATENTS 2010 Simon, O.; Reux, B.; La Clair, J J.; Lear, M J Total Synthesis Confirms Laetirobin as a Formal Diels–Alder Adduct Chem-Asian J 2010, 5, 342-351 2009 Lear, M J., Simon, O., Foley, T L., Burkart, M D., Baiga, T J., Noel, J P., DiPasquale, A G., Rheingold, A L., La Clair, J J Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia J Nat Prod 2009, 72, 1 980 -87 ... Ingelheim Pharma, Ingelheim, Germany 1999 - 2000 5-month practical semester in the Drug Delivery Department • Conducted and evaluated gravimetric measurements for the development of Respimat , a new-generation, propellant-free liquid drug aerosol delivery device for inhalation therapy ® German Armed Forces, Gerolstein, Germany 1995 - 1996 National military service in the Army’s Communication Corps PUBLICATIONS... (SICC 6), Singapore, 2009 Reux B., Simon O., La Clair J J., Lear M J Total Synthesis of Laetirobin: a Late-Stage Mitotic Blocker that Induces Cell Death (poster presentation) rd 3 Mechanobiology Workshop, NUS, Singapore, 2009 Simon O., Reux B., La Clair J J., Lear M J Discovery of Laetirobin as a Late-Stage Mitotic Blocker that Induces Programmed Cell Death (poster presentation) th 57 Natural Products... Research Conference, Tilton, NH, USA, 20 08 Lear M J., Simon O., Foley T L., Burkart M D., Baiga T J., Noel J P., DiPasquale A G., Rheingold A L., La Clair J J Discovery of Laetiporina A as a Selective Mitotic Blocker (poster presentation) PROFESSIONAL POSITIONS Member American Chemical Society 2009 - present LANGUAGE PROFICIENCY • German: mother language • English: written and spoken COMPUTER PROFICIENCY... PROFICIENCY • Windows including Office 2007 • ChemDraw 12.0, SciFinder, Beilstein, EndNote X4, WinNMR ACTIVITIES & INTERESTS • Sports (Cycling, Soccer, Basketball) • Travelling (Africa, Asia, Australia, Europe) • Music PERSONAL PARTICULARS • Date of birth: 8 July 1975 • Place of birth: Bernkastel-Kues, Germany • Marital status: Single • Nationality: German th rd Singapore, 03 May 2011 ... treatment and prevention of cancer Patent: WO 2006040 281 (Boehringer Ingelheim International GmbH, Germany; Boehringer Ingelheim Pharma GmbH & Co KG) 131 pp 2002 Heindl, D., Herrmann R., Josel, H.-P., Huber, E., Klause, U., Simon, O Luciferin hydrazides Patent: WO 20020994 28 (Roche Diagnostics GmbH., Germany; F Hoffmann-La Roche AG) 35 pp CONFERENCE PRESENTATIONS th 6 Singapore International Chemistry Conference... Brandl, T., Breitfelder, S., Brueckner, R., Gerstberger, T., Gmachl, M., Grauert, M., Hilberg, F., Hoenke, C., Hoffmann, M., Impagnatiello, M., Kessler, D., Klein, C., Krist, B., Maier, U., McConnell, D., Reither, C., Scheuerer, S., Schoop, A. , Schweifer, N., Simon, O., Steegmaier, M., Steurer, S., Waizenegger, I., WeyerCzernilofsky, U., Zoephel, A Preparation of thiazoloindazoles for treatment and . Singapore Medicinal Chemistry Programme (PhD student under the supervision of Dr. Martin Lear) • Affinity- Guided Isolation, Structure Elucidation and Total Synthesis of Laetirobin A and. Appendix 8 X-ray Data Appendix 8 4 18 Crystal data and structure refinement for 2-1 Identification code 83 09 Empirical formula C45 H33 Cl3 O12 Formula weight 87 2.06 Temperature. 2.012 and -0.961 e.Å -3 X-ray Data 425 Crystal data and structure refinement for 5-41 Identification code a1 81 Empirical formula C12 H12 O2 Formula weight 188 .22 Temperature