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:hhZci^Vahd[ E]VgbVXZji^XVa8]Zb^hign I]^gYZY^i^dc 9dcVaY8V^gch Essentials of Pharmaceutical Chemistry [...]... practice of pharmacy The number of UK Schools of Pharmacy is set to double, independent pharmacist prescribing is a reality, and the Royal Pharmaceutical Society is set to split with the creation of a regulatory body and a Royal College This third edition of Essentials of Pharmaceutical Chemistry has been written against this backdrop of major change A new chapter on regulation and licensing of drugs... Sunderland), Dr Cairns moved to Leicester Polytechnic (now De Montfort University) where he held a fiveyear lectureship in Pharmacy In 1992 Dr Cairns was appointed senior lecturer in medicinal chemistry in Sunderland School of Pharmacy and in 2003 moved to his present post of Associate Head of the School of Pharmacy at The Robert Gordon University in Aberdeen In 2006, he was promoted to Professor of Pharmaceutical. .. comprehensive understanding of the chemical structure of the drug and how this chemical structure influences the properties and behaviour of the drug in the body For these reasons, chemistry is the most important of all the scientific disciplines contributing to the understanding of drugs and their actions in the body A good understanding of the chemistry of drugs will allow the study of advanced topics such... electrolytes, however, the dissociation can be expressed by the law of mass action in terms of the equilibrium constant 2 Essentials of pharmaceutical chemistry Considering the reaction AϩB3CϩD the equilibrium constant (K) for the reaction is given by the product of the concentrations of the reaction products divided by the product of the concentrations of the reactants, or [C] ϫ [D] K ϭ ––––—— [A] ϫ [B] Clearly,... 10 mL of 1 M alkali has only increased the pH of the buffer by a small amount By way of comparison, if 10 mL of 1 M NaOH were added to 1 litre of pure water, the pH of the solution would increase from a pH of 7 to a value of approximately 12 This can be easily shown by using the term, pOH, which is defined as the negative logarithm of the OHϪ Chemistry of acids and bases 15 concentration in a similar... an expression for the strength of acid solutions If the acid, HA, ionises to a moles of Hϩ ions and a moles of OHϪ ions, where a is the fraction of the acid that is ionised, then the number of moles of undissociated acid is given by (1 Ϫ a) This acid solution can now be prepared with c moles of acid in 1 litre (or 1 dm3), which will yield ac moles of Hϩ and ac moles of AϪ Hence, HA 3 (1 Ϫ a)c ac ϫ... Medicinal Chemistry at RGU Professor Cairns has been external examiner at Strathclyde, Liverpool and Aberdeen Schools of Pharmacy and has authored over 50 peer reviewed research papers His research interests include the design and synthesis of selective anticancer agents, the molecular modelling of drug–DNA interactions and the design of prodrugs for the treatment of nephropathic cystinosis Donald Cairns. .. prodrugs for the treatment of nephropathic cystinosis Donald Cairns is a member of the Royal Pharmaceutical Society of Great Britain (RPSGB), the Royal Society of Chemistry and the Association of Pharmaceutical Scientists In 2006 he was appointed to the British Pharmacopoeia Commission and serves on an Expert Advisory Group of the Commission on Human Medicines To travel hopefully is a better thing than... in pharmaceutical and biological systems is water, the ionisation of a weak acid is better represented as HA ϩH2O 3 H3Oϩ ϩ AϪ where H3Oϩ is a hydroxonium ion, and the ionisation of a base can be represented as B ϩH2O 3 BHϩ ϩOHϪ 4 Essentials of pharmaceutical chemistry It is important to notice that water appears in these equations as both a proton acceptor and a proton donor This is an example of the... Stevenson, 1850–1894 1 Chemistry of acids and bases Chemistry is the defining science of pharmacy To understand anything about a drug – the synthesis, the determination of its purity, the formulation into a medicine, the dose given, the absorption and distribution around the body, the molecular interaction of drug with its receptor, the metabolism of the drug and, finally, the elimination of drug from the . :hhZci^Vahd[ E]VgbVXZji^XVa8]Zb^hign I]^gYZY^i^dc 9dcVaY8V^gch Essentials of Pharmaceutical Chemistry