[...]... and similar veins that focus on neurotoxicology This textbook, Clinical Neurotoxicology, is an attempt to address the underrepresented discipline of clinical neurotoxicology in a logical, comprehensible, and comprehensive manner It would not be possible to include all aspects of this immensely broad field of study in a single text This work focuses on clinical aspects of neurotoxicology germane to medical... Introduction to Clinical Neurotoxicology ENVIRONMENTAL NEUROLOGY Aside from neurological disorders caused by toxins, many environments are known to either directly cause or predispose an individual for neurological problems Some environments also place humans at risk for unique or unusual neurological troubles Potentially neurotoxic environments include mountains (altitude sickness), marine environments. .. Schaumburg HH Experimental and Clinical Neurotoxicology New York: Oxford University Press; 2000 7 Feldman RG Approach to Diagnosis: Occupational and Environmental Neurotoxicology Philadelphia: Lippincott-Raven; 1999 CHAPTER 2 Cellular and Molecular Neurotoxicology: Basic Principles David R Wallace CHAPTER CONTENTS Historical Perspective of Neurotoxicology 7 Molecular Neurotoxicology 12 Neurotoxic Endpoints,... dopaminergic Chapter 2 • Cellular and Molecular Neurotoxicology: Basic Principles Table 1: Societies and Journals with Neurotoxicology Emphasis in 2008 Societies Journals Behavioral Toxicology Society Neurotoxicity Research International Neurotoxicology Association Neurotoxicology Neurobehavioral Teratology Society Neurotoxicology and Teratology Neurotoxicity Society Neurotoxicology Specialty Section of the... where currently clinically relevant The work is divided into six sections The first section, Neurotoxic Overview, is an overview of clinical neurotoxicology, with chapters encompassing basic science relevant to clinical practitioners, the approach to neurotoxic patients, and overviews of the development, industrial, and occupational medicine aspects of the field The second section, Neurotoxic Syndromes, contains... situations and environments and expose ourselves to novel substances Some of these environments and substances may be harmful It is reasonable to expect that we will continue to experience diseases caused by toxins and environments throughout our future as a species It is reasonable to expect that many of these will be toxic to the human nervous system CONTROVERSIES As a young field of study, clinical neurotoxicology. .. Practitioners It makes sense that clinical neurotoxicologists would be neurologists, and arguably, every fully trained neurologist should have sufficient expertise to diagnose and manage common neurotoxic disorders However, formal clinical neurotoxicology training is lacking in most neurology residency programs, and no neurology fellowships are available to study clinical neurotoxicology Therefore, most... Systems 8 Summary and Clinical Considerations 13 Cellular Neurotoxicology 9 HISTORICAL PERSPECTIVE OF NEUROTOXICOLOGY It has been long known that a variety of compounds and insults can be toxic to the central nervous system (CNS) Only in the last 20 to 25 years has the study of neurotoxicology intensified and focused attention on specific agents and diseases A good indicator of the growth of neurotoxicology. .. problem Many clinical neurotoxicology syndromes can be quite challenging to diagnose, and some are still being defined neurologically Therefore, a role is available today for competent clinical neurologists in evaluating, diagnosing, and treating patients with neurotoxic disorders It follows that there should also be room in neurology training programs for some time dedicated to studying clinical neurotoxicology. .. substances that could be implicated based on the patient’s clinical picture For additional details of testing or treatment of specific neurotoxic substances, they would then seek more information in the third and fourth sections of this book (Neurotoxic Testing and Neurotoxic Substances, respectively) The fifth and sixth sections of the book (Neurotoxic Environments and Conditions, and Neurotoxic Weapons and . 3 Clinical Neurotoxicology 3 Environmental Neurology 6 Controversies 6 Conclusion 6 Introduction to Clinical Neurotoxicology Michael R. Dobbs 1 CHAPTER Chapter 1 • Introduction to Clinical Neurotoxicology 4 highly. book. The Publisher Library of Congress Cataloging-in-Publication Data Clinical neurotoxicology : syndromes, substances, environments / [edited by] Michael R. Dobbs. — 1st ed. p. ; cm. Includes. his book, Clinical Neurotoxicology: Syndromes, Substances, Environ- ments. This multi-authored, but carefully edited, text pro- vides a clinical approach to the fi eld of neurotoxicology, using