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A novel statistical procedure Detecting differential splicing is presented that uses probe-level information on Affymetrix exon arrays to detect differential splicing.
Thông tin tài liệu
A novel statistical procedure Detecting differential splicing is presented that uses probe-level information on Affymetrix exon arrays to detect differential splicing.
Ngày đăng: 14/08/2014, 21:20
Mục lục
Abstract
Background
Results
Performance in synthetic data
Reproducibility of detections in the mixture data
Reproducibility of detections between laboratories
Reproducibility of detections between independent subsamples
Detection of confirmed splicing events
Discussion
Conclusions
Materials and methods
Detection of differential splicing
Intensity model
Splicing index
Probe-level expression change averaging
PECA splicing index
FIRMA algorithm
Two-way ANOVA approaches
Filtering
Implementation
Datasets and evaluation criteria
Synthetic data
Mixture data
Between-laboratory comparison data
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