Báo cáo y học: "Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation" pot

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Open Access Volume et al Wong 2007 8, Issue 5, Article R72 Research Yong Wee Wong*, Christian Schulze*, Thomas Streichert†, Richard M Gronostajski‡, Melitta Schachner*§ and Thomas Tilling* reviews Addresses: *Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany †Institut für Klinische Chemie, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany ‡Department of Biochemistry and Program in Neuroscience, State University of New York at Buffalo, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA §Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, D-251, Piscataway, NJ 08854, USA comment Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation Correspondence: Thomas Tilling Email: thomas.tilling@zmnh.uni-hamburg.de Published: May 2007 Received: February 2007 Accepted: May 2007 Genome Biology 2007, 8:R72 (doi:10.1186/gb-2007-8-5-r72) reports The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2007/8/5/R72 © 2007 Wong et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited godendrocyte mice in NFI-A-deficient mice it>+/+ maturation suggests that Nfia-/- mice are delayed in early postnatal development, especially oli

Gene expression analysis of Delayed brain maturation.

brains from mice deficient in nuclear factor I-A (Nfia-/- mice) and from Nfia

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Báo cáo y học: "Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation" pot

Thông tin tài liệu

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Abstract

Background

Results

Conclusion

Background

Results

Microarray analysis

Gene function

Quantitative real-time PCR validation of microarray results

In silico promoter analysis

Discussion

Gene function

Oligodendrocyte differentiation

Axonal growth and guidance

Promoter analysis

Conclusion

Materials and methods

Animals

RNA preparation

Microarray hybridization and signal detection

Microarray quantification and statistical analysis

Accession numbers

Reverse transcription and quantitative real-time PCR

Computer-based promoter analysis

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