Chapter 034. Cough and Hemoptysis (Part 2) Approach to the Patient: Cough A detailed history frequently provides the most valuable clues for the etiology of the cough. Particularly important questions include: 1. Is the cough acute, subacute, or chronic? 2. At its onset, were there associated symptoms suggestive of a respiratory infection? 3. Is it seasonal or associated with wheezing? 4. Is it associated with symptoms suggestive of postnasal drip (nasal discharge, frequent throat clearing, a "tickle in the throat") or gastroesophageal reflux (heartburn or sensation of regurgitation)? However, the absence of such suggestive symptoms does not exclude either of these diagnoses. 5. Is it associated with fever or sputum? If sputum is present, what is its character? 6. Does the patient have any associated diseases or risk factors for disease (e.g., cigarette smoking, risk factors for infection with HIV, environmental exposures)? 7. Is the patient taking an ACE inhibitor? The general physical examination may point to a systemic or nonpulmonary cause of cough, such as heart failure or primary nonpulmonary neoplasm. Examination of the oropharynx may provide suggestive evidence for postnasal drip, including oropharyngeal mucus or erythema, or a "cobblestone" appearance to the mucosa. Auscultation of the chest may demonstrate inspiratory stridor (indicative of upper airway disease), rhonchi or expiratory wheezing (indicative of lower airway disease), or inspiratory crackles (suggestive of a process involving the pulmonary parenchyma, such as interstitial lung disease, pneumonia, or pulmonary edema). Chest radiography may be particularly helpful in suggesting or confirming the cause of the cough. Important potential findings include the presence of an intrathoracic mass lesion, localized pulmonary parenchymal opacification, or diffuse interstitial or alveolar disease. An area of honeycombing or cyst formation may suggest bronchiectasis, while symmetric bilateral hilar adenopathy may suggest sarcoidosis. Pulmonary function testing (Chap. 246) is useful for assessing the functional abnormalities that accompany certain disorders producing cough. Measurement of forced expiratory flow rates can demonstrate reversible airflow obstruction characteristic of asthma. When asthma is considered but flow rates are normal, bronchoprovocation testing with methacholine or cold-air inhalation can demonstrate hyperreactivity of the airways to a bronchoconstrictive stimulus. Measurement of lung volumes and diffusing capacity is useful primarily for demonstration of a restrictive pattern, often seen with any of the diffuse interstitial lung diseases. If sputum is produced, gross and microscopic examination may provide useful information. Purulent sputum suggests chronic bronchitis, bronchiectasis, pneumonia, or lung abscess. Blood in the sputum may be seen in the same disorders, but its presence also raises the question of an endobronchial tumor. Greater than 3% eosinophils seen on staining of induced sputum in a patient without asthma suggests the possibility of eosinophilic bronchitis. Gram and acid- fast stains and cultures may demonstrate a particular infectious pathogen, while sputum cytology may provide a diagnosis of a pulmonary malignancy. More specialized studies are helpful in specific circumstances. Fiberoptic bronchoscopy is the procedure of choice for visualizing an endobronchial tumor and collecting cytologic and histologic specimens. Inspection of the tracheobronchial mucosa can demonstrate endobronchial granulomas often seen in sarcoidosis, and endobronchial biopsy of such lesions or transbronchial biopsy of the lung interstitium can confirm the diagnosis. Inspection of the airway mucosa by bronchoscopy may also demonstrate the characteristic appearance of endobronchial Kaposi's sarcoma in patients with AIDS. High-resolution computed tomography (HRCT) can confirm the presence of interstitial lung disease and frequently suggests a diagnosis based on the specific abnormal pattern. It is the procedure of choice for demonstrating dilated airways and confirming the diagnosis of bronchiectasis. A diagnostic algorithm for evaluation of subacute and chronic cough is presented in Fig. 34-1. Figure 34-1 Algorithm for management of cough lasting >3 weeks. Cough between 3 and 8 weeks is considered subacute; cough >8 weeks is considered chronic. Hx, history; PE, physical examination; ACEI, angiotensin-converting enzyme inhibitor; Rx, treat; CXR, chest x-ray. . Chapter 034. Cough and Hemoptysis (Part 2) Approach to the Patient: Cough A detailed history frequently provides the most valuable clues for the etiology of the cough. Particularly. of subacute and chronic cough is presented in Fig. 34-1. Figure 34-1 Algorithm for management of cough lasting >3 weeks. Cough between 3 and 8 weeks is considered subacute; cough >8. endobronchial tumor and collecting cytologic and histologic specimens. Inspection of the tracheobronchial mucosa can demonstrate endobronchial granulomas often seen in sarcoidosis, and endobronchial