1 ORGANIC CHEMISTRY Dr Nam T. S. Phan Faculty of Chemical Engineering HCMC University of Technology Office: room 211, B2 Building Phone: 8647256 ext. 5681 Email: ptsnam@hcmut.edu.vn 2 Chapter 13: AMINES-DIAZONIUM SALTS 3 NOMENCLATURE OF AMINES Common names: alkyl + amine 4 IUPAC names: alkan + amine 5 Substituents are listed in alphabetical order, regardless of whether they are attached to the nitrogen or the hydrocarbon 6 PREPARATIONS OF AMINES Alkylation of ammonia 7 Gabriel synthesis of primary amines 8 Amines by reduction 9 Preparation of arylamines 10 • It is possible to selectively reduce just 1 of 2 nitro groups using S 2- • H 2 /Pd, Fe/HCl… will reduce both nitro groups 1:1 molar ratio [...]... agents 20 Reaction of primary amines with HNO2 HNO2 is unstable, aqueous NaNO2 / acid should be used Stable NOT stable 21 Mechanism: 22 23 Alkyl diazonium salt is NOT stable 24 REACTIONS OF DIAZONIUM SALTS Sandmeyer reactions KCl, KBr can NOT be used in place of CuCl, CuBr 25 This Cl is from CuCl 26 Schiemann reaction 27 Preparation of phenol from diazonium salt 28 Reductive deaminations Anhydrous . Technology Office: room 211, B2 Building Phone: 8647256 ext. 5681 Email: ptsnam@hcmut.edu.vn 2 Chapter 13: AMINES-DIAZONIUM SALTS 3 NOMENCLATURE OF AMINES Common names: alkyl + amine 4 IUPAC names: alkan