[...]... Obstetrics and Gynecology, and the General Clinical Research Center, Georgetown University Medical Center, and MedStar Research Institute, Washington, District of Columbia, USA Ronald G Victor Texas, USA Divisions of Hypertension and Cardiology, University of Texas Southwestern Medical Center, Dallas, Donald G Vidt Department of Nephrology and Hypertension, The Cleveland Clinic Foundation, Cleveland, Ohio,... Birmingham and Midland Eye Centre and City Hospital, Birmingham, UK University Department of Medicine, City Hospital, Birmingham, UK ¨ Thomas F Luscher ¨ Department of Cardiology, University Hospital, Zurich, Switzerland Robert J MacFadyen Birmingham, UK Marc Maillard University Department of Medicine and Department of Cardiology, City Hospital, Service of Nephrology, CHUV, Lausanne, Switzerland ` Giuseppe... University Hospital Basel, Basel, Switzerland Medical Outpatient Department, University Hospital, Basel, Switzerland Pieter A van Zwieten Universiteit van Amsterdam, Amsterdam, The Netherlands Part A: History, Definitions, and Epidemiology 1 History of Hypertension LAWRENCE R KRAKOFF Mount Sinai School of Medicine, New York, New York and Englewood Hospital and Medical Center, Englewood, New Jersey,... measurement and its importance in the diagnosis of hypertension History of Hypertension 11 lessons of the trials are translated into more widespread and appropriate treatment and the current basic science relevant to this field is, in time, translated into better care for the very large number of those with high blood pressure REFERENCES 1 Figure 1.5 Dr Pickering and his colleagues extended and expanded... Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S, and for the REENAL Study Investigators Effects of losartan on renal and cardiovascular outcomes in patients with type-2 diabetes and nephropathy N Engl J Med 2001; 345:861 – 869 Parving H-H, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P, and for the Irbesartan in Patients with Type-2 Diabetes and Microalbuminuria Study Group The effect of... Lewis EJ, and for the Collaborative Study Group Cardiovascular outcomes in the irbesartan diabetic nephropathy trial of patients with type-2 diabetes and overt nephropathy Ann Intern Med 2003; 138:542– 549 Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJV, Michelson EL, Olofsson B, Ostergren J, Yusuf S, and for the CHARM Investigators and Committees Effects of candesartan on mortality and morbidity... Westerling S, and for the Hot Study Group Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized trial Lancet 1998; 351:1755– 1762 Hansson L, Hedner T, Lund-Johansen P, Kjeldsen SE, Lindholm LH, Syvertsen J-O, Lanke J, de Faire U, Dahlof B, Karlberg BE, and for the NORDIL Study Group Randomized... Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA Donna S Hanes Maryland, USA Jiang He Division of Nephrology, Department of Medicine, University of Maryland Medical System, Baltimore, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA Martha N Hill The Johns Hopkins University School of Nursing, Baltimore, Maryland, USA... be beneficial in the prevention of stroke and, perhaps, in the prevention of ischemic heart disease, as well Two 7 large, randomized and placebo-controlled clinical trials were conducted to test the hypothesis—one in the United States and the other in Europe Taken together, the results of both the Systolic Hypertension in the Elderly Program (SHEP) trial (21) and the Systolic Hypertension in Europe (Syst-Eur)... week of practice) for a duration of 5 years will prevent one fatal or nonfatal stroke Such calculations combined with analyses of cost-effectiveness may be the guide for optimal decision-making strategies in the future VI COMPARISON OF STRATEGIES IN TRIALS SINCE 1990 Beginning in the 1970s and accelerating into the 1980s and 1990s, the pharmacology of antihypertensive and cardiovascular drugs expanded . that Hypertension: Principles and Practice will serve our many hypertension patients by supporting their health care providers with a useful and comprehensive source of accurate information and. has been to compile and present information about the most relevant underlying principles of hypertension and apply them to clinical practice. It takes facets of basic research and applies these concepts. concomitant emphasis on principles and practice. Emphasis on the clinical aspects and patient management as well as on the molecular, biological, physiological, pathophysiological, and pharmacological