[...]... trained, or by professional workers in allied disciplines Companion to Clinical Neurology is a personal endeavour to provide answers to questions like these I have tried to incorporate within it some science, some art, some history, some practical experience It is also a hive in which there nest numerous bees formerly resident in my bonnet and which needed more lebensraum It is designed for the bedside... gangliosidosis characterized by deficiency of GM2 activator factor, leading to the accumulation of GM2 ganglioside See GM2 gangliosidosis Ab-related angiitis (isolated or primary angiitis of the nervous system, ABRA, granulomatous angiitis) An idiopathic relapsing, focal, necrotizing, giantcell angiitis of young or middle-aged adults, characterized by sterile inflammation of the small- and medium-sized intracranial,... devoted to this condition include the following: American Autoimmune Related Diseases Association A charitable organization in this field Address: 22100 Gratiot Ave Eastpointe, East Detroit, MI 4820 1-2 227 Tel: 58 6-7 7 6-3 900; 80 0-5 9 8-4 668 E-mail: aarda@aol.com Web site: http:// www.aarda.org/ Guillain–Barre Foundation International P.O Box 262 Wynnewood, PA 19096 E-mail: gbint@netcom.com Tel: 61 0-6 6 7-0 131... realities even of a retired academic life WILLIAM PRYSE- PHILLIPS St John’s, Newfoundland, Canada January 2009 OU P PR OD UC TN OT FO RS gracious support, another edition of the Companion would have been impossible to produce Again, I offer my sincere thanks I gladly acknowledge my debt to Oxford University Press (a not-or-profit publisher) and to my editors Craig Panner and David D’Addona for their confidence... millimeter Medication overuse headache monoamine oxidase inhibitors motor nerve conduction velocity magnetic resonance imaging neurodegeneration with brain iron accumulation Abbreviations used in this book xvi Dr R Mark Sadler seconds sensory nerve action potential Single Photon Emission Computed Tomography short-latency somatosensory evoked potential selective serotonin reuptake inhibitor Vascular... access to his personal library I am also grateful to the reviewers of the two preceding editions, to many colleagues for their kind comments and suggestions and to Dr Chern Lim, currently (2009) a senior resident in our neurology program, who assisted me greatly in the discovery and analysis of many of the Web sites listed here I am most grateful to Dr John Noseworthy, the American Academy of Neurology. .. infrequently, but tonic-clonic seizures are commonly associated The EEG shows generalized polyspike-and-wave activity triggered by hyperventilation and remission of seizures is uncommon.4039 In further variant forms, myoclonic jerks, versive movements, or atonic periods are associated, in which case the tendency for the typical or complex absence attacks to cease at puberty is not manifest Generalized tonicclonic... recessively inherited syndrome of intermittent vomiting, hypotonia, lethargy, symptoms of increased intracranial pressure and bulbar symptoms The use of and opisthotonus, with death in early infancy, due to deficiency of lysosomal acid computerized axial tomography, magnetic resonance imaging and brainstem auditoryphosphatase.4570 evoked responses in the diagnosis of the condition has been reviewed.2785 acidemia... of Dr Victor McKusick and (through his superb Web site) Dr Alan Pestronk provided me with data on, and analyses of, many disorders that I would otherwise failed to catalogue The transformation of the second to the third edition has required over a year of full-time effort, aided by the Internet and the assistance of scholarly peers I wish to record again my debt to Dr Alan Pestronk of Washington University,... is included for most of the entries delineating diseases, usually representing that publication on the subject which brought the material first to attention or one to which the interested reader may turn in order to receive more precise directions along the road to further knowledge; but in some instances it is to that paper on the subject which I most enjoyed reading The Companion is designed as a . Cataloging-in-Publication Data Pryse- Phillips, William. Companion to clinical neurology/ William Pryse- Phillips. — 3rd ed. p. ; cm. Includes bibliographical references. ISBN 97 8-0 -1 9-5 3677 2-0 (alk.paper) Neurology Dictionaries practice; to reinforce understanding with a little history; and to indicate resources that a clinical neurologist might now and then need to consult. What started as a 75,000 word work has turned into. naı¨ve to an experienced neurologist, but need an answer when asked by students or by physicians who are not so trained, or by professional workers in allied disciplines. Companion to Clinical Neurology