VII Practical LSD Manufacture 3rd Edition [...]... should then be stored in a glass container in a cool, dark place Practical LSD Manufacture 24 Four: LSD Directly From The Lysergic Amides - The One-Pot Shot 25 Four: LSD Directly From The Lysergic Amides - The One-Pot Shot When the lysergic amides have been extracted in pure form from the crop, work should begin without delay to convert it to LSD Diligence in this matter is very important because possession... produce isolysergic acid hydrazide The hydrazide is then isolated by Practical LSD Manufacture 26 extraction, and reacted with acetylacetone (2,4-pentanedione) to form a pyrazole intermediate, which is then reacted with diethylamine to form iso- LSD A bit of warm KOH in methanol then gives conversion of the iso -LSD to the active form of LSD This method at first glance seems complicated, but the actual... ergot are ripe, they should be harvested The individual grains will not all sprout or ripen at the same time, so this is a harvest one-grainat-a-time operation The ripe grain is carefully scooped out of the sand with a spoon, and the sand is then dilute-bleach-water-misted away to leave the bare grain covered with mushrooms Care must be taken when handling the sprouted ergot, as rough handling will... expect success in the production of high-grade LSD if care is taken throughout the procedure to ensure that the materials used meet the requirement of a reasonable degree of purity The actual synthesis of LSD is an exquisite combination of farming skills, biology, biochemistry and organic chemistry In its preferred embodiment, a scheme for the large-scale manufacture of LSD would center around someone playing... have one thing in common - they are amides of lysergic acid See the structures of the major naturally occurring amides pictured below: Practical LSD Manufacture 4 ergine CH, ergonovine ergotamine They all contain the lysergic acid molecule shown below: The lysergic acid molecule is the key to all known methods of LSD production The common thread that all the synthetic routes to LSD share is that the path... been reduced to one-fifteenth of its original volume, it must be diluted with ether The reason for this is Practical LSD Manufacture 20 that the next step is extraction of the ergot alkaloids into a tartaricacid solution, and it has been found that this is very difficult from pure chloroform When the solution is predominantly ether, the transfer of the alkaloids into the tartaric-acid solution can... Growing Ergot: 3(1), pages 10 5-1 09 (1970), "Observations on Claviceps purpurea on Spartina alterflora." Canadian Journal of Botany Vol 35, pages 31 5-3 20 (1957), "Studies on Ergot in Gramineous Hosts." Pharmacognosy (1965), pages 32 1-3 27 Agricultural Gazette of New South Wales Vol 52, pages 57 1-5 81 (1941), "Artificial Production of Ergot" Pythopathology Volume 35, pages 35 3-3 60 (1945), "The Field Inoculation... extraction that is about 25% more complete than the USP method It is, however, not nearly as practical as the USP method for large-scale extractions because it would be necessary to dump the crop out of the extraction pipes, and then grind the solid MgO into an intimate mixture with the crop prior to Practical LSD Manufacture 18 extraction with ether The USP method allows the much simpler procedure that... broth loaded with germinated spores which can be sprayed onto the blooming heads of rye, yielding a heavy infection rate of ergot in your patch of rye Practical LSD Manufacture 10 I have some helpful observations to share on the matter of home sterile-culture technique, based upon my own experiences It has been my observation that keeping one's cultures free from contamination by freeloading wild germs... direct citations to their use in making LSD, but should be the best of all methods In all cases, the overriding factor which must take precedence is ease of availability of the required chemicals A bottle of trifluoroacetic anhydride in hand beats homemade anhydrous hydrazine in the bush The first LSD manufacture method presented here is what I like to call "the one-pot shot." It can be found in US patent . VII Practical LSD Manufacture 3rd Edition