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The Global Action Report
on Preterm Birth
Born Too Soon
BORN TOO SOON THE GLOBAL ACTION REPORT ON PRETERM BIRTH
Born Too Soon: The Global Action Report on Preterm Birth features the rst-ever estimates of preterm birth rates by
country and is authored by a broad group of 45 international multi-disciplinary experts from 11 countries, with almost 50
organizations in support. This report is written in support of all families who have been touched by preterm birth. This
report is written in support of the Global Strategy for Women’s and Children’s Health and the efforts of Every Woman Every
Child, led by UN Secretary-General Ban Ki-moon.
Cover photo: Colin Crowley/Save the Children
The Global Action Report
on Preterm Birth
2012
Born Too Soon
The Global Action Report on Preterm Birth
iv
WHO Library Cataloguing-in-Publication Data:
Born too soon: the global action report on preterm birth.
1.Premature birth – prevention and control. 2.Infant, premature. 3.Infant mortality – trends. 4.Prenatal care. 5.Infant care.
I.World Health Organization.
ISBN 978 92 4 150343 3 (NLM classication: WQ 330)
@ World Health Organization 2012
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The named authors alone are responsible for the views expressed in this publication.
Request for copies
North America: globalprograms@marchofdimes.com
Rest of the world: pmnch@who.int
Recommended citation:
March of Dimes, PMNCH, Save the Children, WHO. Born Too Soon: The Global Action Report on Preterm Birth. Eds CP
Howson, MV Kinney, JE Lawn. World Health Organization. Geneva, 2012.
vi Main abbreviations
vi Country groups used in the report
vii Foreword
viii Commitments to preterm birth
1 Executive summary
8 Chapter 1. Preterm birth matters
16 Chapter 2. 15 million preterm births: priorities for action based on
national, regional and global estimates
32 Chapter 3. Care before and between pregnancy
46 Chapter 4. Care during pregnancy and childbirth
60 Chapter 5. Care for the preterm baby
78 Chapter 6. Actions: everyone has a role to play
102 References
112 Acknowledgements
Contents
Photo: March of Dimes
Photo: © Name
The Global Action Report on Preterm Birth
Main Abbreviations
Country groups used in the report
ANC Antenatal Care
BMI Body Mass Index
CHERG Child Health Epidemiology Research Group
CPAP Continuous positive airway pressure
DHS Demographic and Health Surveys
EFCNI European Foundation for the Care of
Newborn Infants
GAPPS Global Alliance to Prevent Prematurity and Stillbirth
GNI Gross National Income
HIV Human Immunodeciency Virus
IMCI Integrated Management of Childhood Illnesses
IPTp Intermittent presumptive treatment during
pregnancy for malaria
IUGR Intrauterine growth restriction
IVH Intraventricular hemorrhage
KMC Kangaroo Mother Care
LAMP Late and moderate preterm
LBW Low birthweight
LiST Lives Saved Tool
LMP Last menstrual period
MDG Millennium Development Goal
MMR Maternal mortality ratio
MOD March of Dimes Foundation
NCD Non-communicable disease
NGO Non-governmental organization
NICU Neonatal intensive care unit
NIH National Institutes of Health, USA
NMR Neonatal mortality rate
PMNCH Partnership for Maternal, Newborn & Child Health
PREBIC International PREterm BIrth Collaborative
pPROM Prelabor premature rupture of membranes
RCT Randomized controlled trials
RDS Respiratory distress syndrome
RMNCH Reproductive, maternal, newborn and child health
SNL Saving Newborn Lives, Save the Children
STI Sexually transmitted infection
UN United Nations
UNFPA United Nations Population Fund
UNICEF United Nations Children’s Fund
WHO World Health Organization
Millennium Development Goal regions: Central & Eastern Asia, Developed, Latin America & the Caribbean, Northern
Africa & Western Asia, Southeastern Asia & Oceania, Southern Asia,
sub-Saharan Africa. For countries see http://mdgs.un.org
World Bank country income classification: High-, middle- and low-income countries (details in Chapter 1)
Countdown to 2015 priority countries: 75 countries where more than 95% of all maternal and child deaths occur
(full list in Chapter 6)
vii
Photo: © Name
Foreword
The response to the 2010 launch of the Every Woman Every Child effort has been very encour-
aging. Government leaders, philanthropic organizations, businesses and civil society groups
around the world have made far-reaching commitments and contributions that are catalyzing
action behind the Global Strategy for Women’s and Children’s Health and the health-related
Millennium Development Goals (MDGs). Born Too Soon is yet another timely answer by
partners that showcases how a multi-stakeholder approach can use evidence-based solutions
to ensure the survival, health and well-being of some of the human family’s most defenseless
members.
Every year, about 15 million babies are born prematurely — more than one in 10 of all babies
born around the world. All newborns are vulnerable, but preterm babies are acutely so. Many
require special care simply to remain alive. Newborn deaths — those in the first month of
life — account for 40 per cent of all deaths among children under five years of age. Prematurity
is the world’s single biggest cause of newborn death, and the second leading cause of all child
deaths, after pneumonia. Many of the preterm babies who survive face a lifetime of disability.
These facts should be a call to action. Fortunately, solutions exist. Born Too Soon, produced
by a global team of leading international organizations, academic institutions and United
Nations agencies, highlights scientifically proven solutions to save preterm lives, provide care
for preterm babies and reduce the high rates of death and disability.
Ensuring the survival of preterm babies and their mothers requires sustained and significant
financial and practical support. The Commission on Information and Accountability for
Women’s and Children’s Health, established as part of the Every Woman Every Child effort,
has given us new tools with which to ensure that resources and results can be tracked. I hope
this mechanism will instill confidence and lead even more donors and other partners to join
in advancing this cause and accelerating this crucial aspect of our work to achieve the MDGs
by the agreed deadline of 2015.
I launched the Global Strategy for Women’s and Children’s Health to draw attention to the
urgency of saving the lives of the world’s most vulnerable people. I was driven not only by my
concern, but by the fundamental reality that what has been lacking in this effort is the will,
not the techniques, technologies or science. We know what to do. And we all have a role to
play. Let us act on the findings and recommendations of this report. Let us change the future
for millions of babies born too soon, for their mothers and families, and indeed for entire
countries. Enabling infants to survive and thrive is an imperative for building the future we want.
Ban Ki-moon
The United Nations Secretary-General
The Global Action Report on Preterm Birth
viii
The Association of Women’s Health, Obstetric and
Neonatal Nurses’ Late Preterm Infant (LPI) Research-
Based Practice Project, supported by Johnson & Johnson,
will raise awareness of risks associated with late preterm
birth, help reduce complications and improve care.
Outcomes include expanding the body of knowledge about
LPI morbidity and increasing nurses’ ability to provide
appropriate care. An Implementation Tool Kit will include
strategies for effective nursing care as pivotal to eliminating
preventable late preterm infant complications.
The Bill & Melinda Gates Foundation commits to reducing
preterm birth through its Family Health agenda with grants
of $1.5 billion from 2010 to 2014 to support three core areas:
coverage of interventions that work (e.g. Kangaroo Mother
Care, antenatal corticosteroids); research and development
of new interventions; and tools to better understand the
burden and reduce the incidence of preterm birth, such as
the Lives Saved Tool and MANDATE Project.
CORE Group will increase awareness about practical
steps to prevent and treat preterm complications to the
CORE Group’s Community Health Network, a community
of practice of over 70 member and associate organizations,
by disseminating this report and other state-of-the-art
information through its working groups, listservs, and social
media channels that reach 3,000 health practitioners around
the world.
The Council of International Neonatal Nurses, Inc.
is strongly committed to increasing awareness of the dan-
gers of premature birth and in supporting the actions in this
report, Born Too Soon, and to the prevention and care of
babies not only because of the key role that neonatal nurses
play in their early lives but also because of the urgent action
needed in reducing the rates of preterm birth and related
mortality and disability.
DFID has set out clear plans to help improve the health of
women and young children in many of the poorest countries
and help save the lives of at least 250,000 newborn babies
and 50,000 women during pregnancy and childbirth by 2015.
The UK’s commitments to improve the lives of women and
children can be found in “UK AID: Changing lives, delivering
results”, on DFID’s website.
The European Foundation for the Care of Newborn
Infants in partnership with the Global Alliances, March of
Dimes and other organizations, looks forward to reducing
the severe toll of prematurity in all countries. As prematurity
poses a serious and growing threat to the health and well-
being of the future European population, EFCNI commits
to making maternal and newborn health a policy priority in
Europe by the year 2020.
The Flour Fortication Initiative joins efforts to see babies
delivered at full term through communication, advocacy
and technical support for increased fortication of foods
in developing countries. Studies indicate a link between
maternal iron deciency anemia in early pregnancy and a
greater risk of preterm delivery, and insufcient maternal
folic acid can lead to neural tube defects, one cause of
preterm deliveries. Projects include campaigns in Nigeria
and Ethiopia and support to Uganda, Mozambique and
elsewhere.
The GAVI Alliance will help developing countries advance
the control and elimination of rubella and congenital rubella
syndrome through immunisation. Each year, 110,000 babies
are born with severe birth defects from congenital rubella
syndrome because their mothers were infected with rubella
virus early in pregnancy. About 80% of those babies are
born in GAVI-eligible countries. By 2015, over 700 million
children will be immunised through campaigns and routine
immunisation with combined measles-rubella vaccine.
Commitments to preterm birth
In support of the Every Woman Every Child effort to advance the Global Strategy on Women’s and Children’s Health,
more than 30 organizations have provided commitments to advance the prevention and care of preterm birth. These
statements will now become part of the overall set of commitments to the Global Strategy, and will be monitored
annually through 2015 by the independent Expert Review Group established by the Commission on Information and
Accountability for Women’s and Children’s Health. For the complete text of each commitment, please visit: http://
everywomaneverychild.org/borntoosoon
commitments
ix
The Global Alliance for Clean Cookstoves at the UN
Foundation will fund up to US$ 800,000 over the next two
years for research on the link between the use of traditional
cookstoves and child survival. It will focus on adverse
pregnancy outcomes, including low birth weight, pre-term
birth, and birth defects; and/or severe respiratory illness
including pneumonia in children under-ve years of age.
This research will hopefully identify new interventions to
reduce premature births worldwide.
Global Alliance to Prevent Prematurity and Stillbirth
(GAPPS) commits to leading global efforts to discover
the causes and mechanisms of preterm birth through the
Preventing Preterm Birth initiative and operating the GAPPS
Repository. GAPPS commits to expanding collaborative
efforts for a global advocacy campaign to promote the critical
need for strategic investment in research and catalyze fund-
ing for it. GAPPS will work to make every birth a healthy birth.
The Home for Premature Babies (HPB) is China’s largest
association of those affected by preterm birth. We unite
400,000 families and work to raise awareness and provide
rehabilitation service for preterm infants. Within 3 to 5 years
we plan to double our membership; publish a monthly
magazine on premature infants; establish a medical tele-
consultation system; develop and implement a continuing
education program for paediatricians; and establish a
branch of HPB in every province in China.
The International Confederation of Midwives will
maintain its commitment to working towards enhancing
the reproductive health of women, and the health of their
newborn, including preventing preterm birth and care for
premature babies, by promoting autonomous midwives as
the most appropriate caregivers for childbearing women
and their newborn and midwifery services as the most
effective means of achieving MDGs 4&5 for child survival
and maternal health.
The International Pediatric Association’s (IPA) 177
pediatric societies support neonatal, child, adolescent
and maternal health through policy advocacy, planning,
expanded health services, pregnancies that are supported
by the entire community and safe delivery for mother and
baby. IPA will feature Born Too Soon on its website and in
the organizational newsletter, encouraging national pediatric
societies to feature this fundamental topic in educational
meetings and policy discussions.
The Japan International Cooperation Agency supports
partner countries in building and strengthening systems
for a “Continuum of Care for Maternal and Child Health”
through technical cooperation US$ 25 million and grant
aid projects of around US$ 13 million annually, and initiat-
ing concessional loans to support partner countries to
achieve MNCH-related MDGs. Japan’s Global Health Policy
2011-2015 commits to saving approximately 11.3 million
children’s lives and 430,000 maternal lives in cooperation
with other donors.
The Johns Hopkins Bloomberg School of Public Health
is committed to strengthening evidence on the extent and
causes of preterm births globally and to developing cultur-
ally and economically appropriate interventions to reduce
the burden of premature birth around the world. We also
commit to working with governments and their partners
on the translation of evidence into effective policies and
programs. We aim to achieve measurable results of our
efforts by 2015.
The Kinshasa School of Public Health in the Democratic
Republic of the Congo, with its partner the University of
North Carolina, has joined the Global Alliance to Prevent
Prematurity and Stillbirth (GAPPS) and submitted a proposal
aimed at preventing preterm birth. The goal of this initiative
is to encourage scientic studies that will lead to or rene
preventive interventions for preterm birth and still birth related
to preterm birth, primarily in developing world settings.
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The Global Action Report on Preterm Birth
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The London School of Hygiene & Tropical Medicine
(LSHTM) has a strategic long-term commitment to research
through the MARCH Centre for Maternal, Reproductive
and Child Health and will continue to improve the data and
evidence base and to advance and evaluate innovative
solutions for the poorest women and babies. LSHTM will
work with partners to increase the numbers and capacity
of scientists and institutions in the most affected countries.
The March of Dimes commits to its Prematurity Campaign
through 2020, devoting approximately $20 million annually
to research into the causes of premature birth; collaboration
with key stakeholders to enhance quality and accessibility of
prenatal and newborn care; education and awareness cam-
paigns to identify and reduce risk of prematurity. March of
Dimes has worked with parent groups to create and promote
World Prematurity Day, November 17, to advocate for further
action, including the recommendations in this publication.
Paediatrics and Child Health, College of Medicine,
University of Malawi is committed to improving the care
of newborns in Malawi. Specic efforts are being made to
help premature babies with respiratory distress by introduc-
ing appropriate technologies and enhancing the Kangaroo
Mother Care through teaching and outreach.
The Partnership for Maternal, Newborn & Child Health
commits to developing a companion knowledge summary to
this report; supporting preterm private sector commitments
linked to the Commission on Life-saving Commodities for
Women and Children; promoting World Prematurity Day,
November 17; and tracking yearly progress of these com-
mitments for the annual report of the independent Expert
Review Group related to the Global Strategy and the
recommendations of the Commission on Information and
Accountability for Women’s and Children’s Health.
Preterm Birth International Collaborative (PREBIC)
supports prematurity prevention programs by organizing
workshops for scientists and clinicians around the globe
aimed to build consortiums of investigators. These consor-
tiums identify knowledge gaps in various areas of preterm
birth research and develop protocols to fill these gaps.
PREBIC organizes scientic symposiums in association
with major Obstetrics Congresses to educate health care
professionals regarding ongoing preterm birth research.
PREBIC’s research core supports investigators in high
throughput research.
The Preterm Clinical Research Consortium of Peking
University Center of Medical Genetics (PUCMG) will
work closely with global, regional and national communi-
ties and organizations to raise public awareness of the toll
of preterm birth in China, and continue existing programs
directed at reducing the rate of preterm birth and associated
mortality and disability. Within three years, PUCMG will have
completed a prospective cohort study identifying major risk
factors for preterm birth in the Chinese population.
Save the Children commits to working with partners to
make preventable newborn deaths unacceptable and to
advance implementation of maternal and newborn services,
enabling frontline health workers and empowering families
to provide the care every newborn needs. By 2015, Save
the Children will promote increases in equitable access
for high-impact interventions for preterm babies including:
antenatal corticosteroids to strengthen premature babies’
lungs; Kangaroo Mother Care; neonatal resuscitation;
improved cord care; breastfeeding support; and
effective treatment of neonatal infections.
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COMMITMENTS
TO PRETERM BIRTH
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