[...]... List of Contributors Y UICHI S UGIYAMA Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo Tokyo, Japan sugiyama@mol.f.u-tokyo.ac.jp G ERGELY S ZAKÁCS Institute of Enzymology Hungarian Academy of Sciences M ARTA S ZAMEL Institute of Pharmacology, Medical School Hannover Hannover Germany szamel.marta@mh-hannover.de G RAZIA TAMMA Department of General... likely the result of activation of alternative, ACE-independent pathways of ANG II generation The protective effects of ACE inhibitors on a long-term scale, therefore, are not explained by a reduction of circulating ANG II levels They are either unrelated to inhibition of ANG II generation, or a result of the inhibition of local generation of ANG II Indeed, due to the ubiquitous presence of ACE in endothelial... Environmental Physiology University of Bari Italy C OLIN W TAYLOR Department of Pharmacology University of Cambridge UK cwt1000@cam.ac.uk P ETER C TAYLOR The Kennedy Institute of Rheumatology Division, Faculty of Medicine Imperial College London London, UK peter.c.taylor@imperial.ac.uk A LVIN V T ERRY J R Departments of Pharmacology and Toxicology Medical College of Georgia Augusta, GA USA aterry@mcg.edu... Group Leibniz-Institute for Molecular Pharmacology Berlin Germany P ETER H EISIG Pharm Biology and Microbiology University of Hamburg Hamburg Germany heisig@chemie.uni-hamburg.de C LAUS W H EIZMANN Department of Pediatrics, Division of Clinical Chemistry and Biochemistry University of Zurich Zurich Switzerland heizmann@access.unizh.ch R ICARDO H ERMOSILLA Department of Molecular Pharmacology and Cell Biology... for Molecular Biomedical Research VIB Ghent Belgium Peter.Vandenabeele@dmbr.ugent.be U WE V INKEMEIER Chair of Cell Biology University of Nottingham Medical School School of Biomedical Sciences Nottingham, NG7 2UH uwe.vinkemeier@nottingham.ac.uk A NDRÁS V ÁRADI Institute of Enzymology Hungarian Academy of Sciences Hungary varadi@enzim.hu G IRISH V YAS Department of Laboratory Medicine University of. .. and Molecular Medicine Michael G DeGroote School of Medical McMaster University Hamilton, ONT Canada twarken@mcmaster.ca TANYA M WATTERS School of Biochemistry and Immunology Trinity College Dublin Ireland D AVID J WAXMAN Division of Cell and Molecular Biology Department of Biology Boston University Boston, MA USA djw@bu.edu J ÜRGEN W ESS Laboratory of Bioorganic Chemistry, National Institutes of Health... T HOMAS E W ILLNOW Max-Delbrueck-Center for Molecular Medicine Berlin Germany willnow@mdc-berlin.de S USAN W ONNACOTT Department of Biology and Biochemistry University of Bath UK bsssw@bath.ac.uk T HOMAS W ORZFELD Institute of Pharmacology University of Heidelberg Heidelberg Germany Y OSEF YARDEN Department of Biological Regulation The Weizmann Institute of Science Rehovot Israel Yosef.Yarden@weizmann.ac.il... enzyme (ACE) This enzyme cleaves a variety of pairs of amino acids from the carboxy-terminal part of several peptide substrates The conversion of ANG I to ANG II and the degradation of bradykinin to inactive fragments are considered the most important functions of ACE [1–3] ACE inhibitors are nonpeptide analogues of ANG I They bind tightly to the active sites of ACE, where they complex with a zinc ion... OHNSON University of North Carolina Chapel Hill, NC USA Gary_Johnson@med.unc.edu R OGER A J OHNSON Department of Physiology and Biophysics State University of New York New York, NY USA roger.johnson@stonybrook.edu xvi List of Contributors H ANS -G EORG J OOST Department of Pharmacology German Institute of Human Nutrition Potsdam-Rehbruecke Germany joost@dife.de T HOMAS J UNGHANSS Section of Clinical Tropical... LEXANDRA C N EWTON Department of Pharmacology University of California at San Diego La Jolla, CA USA anewton@ucsd.edu C OLIN G N ICHOLS Washington University School of Medicine St Louis, MO USA cnichols@wustl.edu M ICHAEL N ILGES Unité de Bio–Informatique Structurale Institut Pasteur Paris France nilges@pasteur.fr YASUO O GAWA Department of Pharmacology Juntendo University School of Medicine Tokyo Japan . class="bi x0 y0 w1 h1" alt="" Encyclopedia of Molecular Pharmacology STEFAN OFFERMANNS AND WALTER ROSENTHAL (Eds.) Encyclopedia of Molecular Pharmacology (2nd edition) With 487 Figures* and. KONSTANTINOV Department of Pharmacology and Toxicology Medical University in Sofia, Faculty of Pharmacy Sofia Bulgaria konstantinov.spiromihaylov@gmail.com K ENNETH S. KORACH National Institute of Environmental. MÄNNISTÖ Division of Pharmacology and Toxicology, Faculty of Pharmacy University of Helsinki Helsinki Finland Pekka.Mannisto@helsinki.fi C HRISTIAN MARTIN Institute of Experimental and Clinical Pharmacology