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CARCINOGEN
Edited by Margarita Pesheva, Martin Dimitrov
and Teodora Stefkova Stoycheva
Carcinogen
Edited by Margarita Pesheva, Martin Dimitrov and Teodora Stefkova Stoycheva
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2012 InTech
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Technical Editor Teodora Smiljanic
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First published June, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from orders@intechopen.com
Carcinogen, Edited by Margarita Pesheva, Martin Dimitrov and Teodora Stefkova
Stoycheva
p. cm.
ISBN 978-953-51-0658-6
Contents
Preface IX
Section 1 Model of Carcinogenesis 1
Chapter 1 The New Model of Carcinogenesis:
The Cancer Stem Cell Hypothesis 3
Brenda Loaiza, Emilio Rojas and Mahara Valverde
Section 2 Environmental Carcinogenesis 33
Chapter 2 Genotoxic Effects of Exposure to
Formaldehyde in Two Different Occupational Settings 35
Susana Viegas, Carina Ladeira, Mário Gomes,
Carla Nunes, Miguel Brito and João Prista
Chapter 3 Ecological Risk Assessment
on the Territory of Belarus After Chernobyl Accident 55
Irina Saltanova, Alexander Malenchenko
and Svetlana Sushko
Chapter 4 Focus on Bisphenol A,
an Uncertain Environmental Pollutant 69
Salvatore Sciacca, Gea Oliveri Conti,
Maria Fiore and Margherita Ferrante
Section 3 Test for Detection of Carcinogens 81
Chapter 5 The Ty1 Retrotransposition Short-Term
Test for Selective Detection of Carcinogenic Genotoxins 83
Teodora Stoycheva, Margarita Pesheva,
Martin Dimitrov and Pencho Venkov
Chapter 6 Isolation and Detection of
Carcinogenic Nucleic Acid Adducts 111
Dickson M. Wambua, Amanda L. Brownstone,
Charles A. Barnes and Norman H. L. Chiu
VI Contents
Section 4 Food and Carcinogens 131
Chapter 7 Carcinogen Role of Food
by Mycotoxins and Knowledge Gap 133
Margherita Ferrante,
Salvatore Sciacca and Gea Oliveri Conti
Chapter 8 Food Borne Carcinogens: A Dead End? 163
Rosa Busquets Santacana
Preface
During the last decades, cancer diseases have increased all over the world. The
low quality of food and strong pollution of environment are the main
prerequisites for carcinogenesis. The main problem for scientists is to find strategy
for prevention of cancer diseases. Therefore, the information about models for
studying carcinogenesis and mutagens which appear during cooking,
environmental pollutants, and tests for specific detection of carcinogens is
particularly important.
The book “Carcinogen” contains a collection of reviews and original papers which
illustrate:
Models of Carcinogenesis - a review focused on the role of stem cells as target to
carcinogenesis
Tests for Detection of Carcinogens - one of the reviews describes different methods for
analyzing nucleic acid adducts, while the other describes the Ty1 retrotransposition
short-term test, which can be used to study carcinogenicity of chemicals, including
such applied in agriculture, nutrition and pharmacy. The test is highly sensitive,
selective to carcinogenic substances, and can be used to control environmental
pollution.
Food and Carcinogens - one of the reviews gives general information about
mycotoxins. Some of them have biological effect on human health, the others,
however, are carcinogenic according to their mechanism of action. The quality of
food depends on the heat treatment during cooking process, which may cause the
formation of mutagenic and carcinogenic compounds. Food industry has to monitor
and control food technology to ultimately reduce food born carcinogens.
Environmental Carcinogenesis - four reviews are closely focused on environmental
pollution with carcinogens and their effect on human health - the risk of leukemia
arising from formaldehyde exposure, the effects of bisphenol A (BPA) exposure to
cancer risk, the consumption of high amount of water containing humic acid, and
genome instability caused by ionizing radiation. The book “Carcinogen” is intended
for biologists, researchers, students in medical sciences and professionals interested in
associated areas.
Dr. Margarita Peshev
Sofia University, Faculty of Biology, Department of Genetics,
Bulgaria
Dr. Martin Dimitrov
Sofia University, Faculty of Biology,
Bulgaria
Dr. Teodora Stefkova Stoycheva
Institute of Cryobiology and Food Technology,
Department of Cryobiology and Lyophilization,
Bulgaria
. CARCINOGEN
Edited by Margarita Pesheva, Martin Dimitrov
and Teodora Stefkova Stoycheva
Carcinogen
Edited by Margarita Pesheva,. obtained from orders@intechopen.com
Carcinogen, Edited by Margarita Pesheva, Martin Dimitrov and Teodora Stefkova
Stoycheva
p. cm.
ISBN 978-953-51-0658-6
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