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Anemia Hemoglobin < g/100 mL Please see Table 98.7 for special guidelines for transfusions in the oncology population Symptoms related to low red If severe anemia, transfuse blood cell mass slowly to avoid precipitating congestive heart failure Thrombocytopenia Coagulopathy CNS symptoms Platelet count < 150,000/mL Please see Table 98.7 for special guidelines for transfusions in the oncology population PT, PTT, fibrinogen, d-dimer Fresh frozen plasma 10 mL/kg If hypofibrinogenemia exists in isolation, treat with cryoprecipitate, 1–2 U/10 kg Platelet transfusion if count 100,000/mL and symptomatic WBC count to screen for Correct coagulopathy (see hyperleukocytosis above) PT, PTT, fibrinogen, d-dimer Platelet transfusion if count to assess risk for CNS
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