... signalling. Indeed,overexpression of SHIP2 inhibited insulin-induced glu-cose uptake and glycogen synthesis in 3T3-L1 adipo-cytes and L6 myotubes [10,11]. SHIP2 also appears toinhibit the insulin-induced ... PtdIns(4,5)P2) SHIP2 +/+ SHIP2 -/-0123456ABCDPtdInsP PtdIns(4,5)P2% (of PtdIns) SHIP2 +/+ SHIP2 -/-PtdIns(3,4,5)P3 levels00,10,20,30,40,50,60,70,80,90 min 10 min%(of PtdIns(4,5)P2) SHIP2 +/+ SHIP2 -/-PtdIns(3,4,5)P3 ... 2-containing inositol 5¢-phosphatase 2via Shc association is required for the negative regula-tion of insulin signaling in Rat1 fibroblasts overexpress-ing insulin receptors. Mol Endocrinol 16,...