... birth of the field of biochemical engineer-ing. Following on the heels of the antibiotic products was the development of efficient microbial processes for the manufacture of vitamins (riboflavin,cyanocobalamine, ... canker of stone fruit trees and holcus spot of maize, and is also a broad-spectrum antibiotic against procaryotes andeucaryotes including Geotrichum candidum [81]. Proof of the role of antibioticsas ... diseases such as take-all (a root and crowndisease) of wheat, black root rot of tobacco, and fusarium wilt of tomato [145].The Natural Functions of Secondary Metabolites21228. Lobareva GS, Zharikova...