... acompetitive inhibitor of EPO in vitro in human EPO signaling systems; its effects in vivo and in murine systems have not been reported, although an intent to study themolecule in animal models was foreshadowed ... firstobserved in dogs, resulting from Ab induced to HuG-CSF crossreacting against canineG-CSF (38) (Table 3). Dogs administered HuG-CSF developed an initial neutrophilia,but with ongoing HuG-CSF administration, ... colony-stimulating factor (rHuGM-CSF, sargramostim, Leukine®or Prokine®) in 1986. The firstagent promoting platelet recovery was formally approved in 1997 (recombinant humaninterleukin-11 [rHuIL-11],...