... a semilogarithmic graph joiningpoints between 200 mg/1 (1.32 mmol /1) at 4 h afteringestion to 50 mg/1 (0.33 mmol /1) at 12 h, thenserious hepatic damage is likely. Patients who ... J M, Thomas S H L2001 Anti-TNF agents for rheumatoid arthritis.British Journal of Clinical Pharmacology 51: 201-208Sneader W 2000 The discovery of aspirin: areappraisal. British ... pathogenesis ofrheumatoid arthritis. The onset of action is fasterthan other DMARDs, providing clinical benefit in4-6 weeks. As the drug is retained in the body for2 years, elimination...