... loss -of- function of BTK and ITK and the gain -of- function fusions ITK–SYK and BTK–SYKAlamdar Hussain1,2,*, Liang Yu1,3,*, Rani Faryal1,2, Dara K. Mohammad1, Abdalla J. Mohamed1,4 and C. I. ... Approximately one-third of all mutations in the BTK gene are missense and some of these reduce the stability of the protein.This is exemplified by mutations in the BTK motif of the Tec homology (TH) ... missing data.The phenotype of XLA and thepotential of BTK and ITK inhibitorsThe outcome of defective BTK signaling in humanshas been described previously in detail [26,27], and therefore we will...