Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
... Research Paper Different effect of exercise on left ventricular diastolic time and interven-tricular dyssynchrony in heart failure patients with and without left bun-dle branch block Gunnar Plehn ... characteristic of heart failure patients which can be explained by the high prevalence of mechanical dyssynchrony. Key words: diastolic time, heart failure, left bundle branch block, exercise test, interventricular ... activation leading to intraventricular dyssynchrony is typically present in patients with LBBB but also common in patients without LBBB (16). As a result of the heterogeneous onset of LV contrac-tion...
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Báo cáo Y học: The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme pdf
... enzymatic reaction steps of aldosteronesynthesis from DOC, s uggesting only minor functionalrelevance of lysine 152 in human C YP11B2. In contrast to the insertion of glutamic acid in position147, ... mainly located in the C-terminal regions of CYP11B1 and CYP11B2. So far, the role of distinct amino acids of theN-terminal regions of human C YP11B isozymes h as n otbeen studied extensively, ... combination of functional data and computer modelling of CYP11B2 suggests an indirectinvolvement of r esidue 147 in the regulation of CYP11Bisoform specific substrate conversion due to its location on the...
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Báo cáo y học: "The Geography of Chronic Obstructive Pulmonary Disease Across Time: California in 1993 and 1999"
... properties of statistical in- ference and underpins the basis of probability theory [18, 19]. Gotway and Young [17] outline a combination of spatial smoothing and geostatistical upscaling or aggregation ... London: Tay-lor and Francis. 1989: 239–247 21. Mugglin AS, and Carlin BP. Hierarchical modeling in geo-graphic information systems: Population interpolation over in- compatible zones. Journal of ... limits the effects of over-smoothing and the linear assumption of density (which is a function of dividing by population) that can result when both in- dependent and dependent density measures...
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Tài liệu Báo cáo Y học: The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region ppt
... the cell cycle-dependent binding of LBR to chromatin is regulated by phosphorylation in thearginine-serine repeat-containing region b y multiple kinases.Keywords: chromatin binding; lamin B receptor; ... the binding of LBR to chromatin. It wasshown that the binding of LBR fragments to chromatin wasstimulated by phosphorylation in the arginine-serine repeat-containing region by a protein kinase(s) ... fragments containing the N -terminal region (residues1–53) and arginine-serine repeat-containing region (residues54–89) bound to chromatin. The b inding of GST-fusionproteins incorporating t he...
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Báo cáo Y học: The refolding of type II shikimate kinase from Erwinia chrysanthemi after denaturation in urea pot
... included in the unfolding and refolding mixtures at a concentration of 40 lM.RESULTSUnfolding of enzymeStability of the enzyme. The loss of secondary and tertiarystructure during unfolding of ... study of theunfolding and refolding of the type II SK from E. chry-santhemi, using studies of CD, fluorescence, activity and ANS fluorescence, and employing both manual mixing and rapid reaction ... in thesamestructuralfamilyastheNMPkinases(adenylatekinase, guanylate kinase, uridylate kinase and thymidinekinase).SK has a number of experimental advantages in estab-lishing the mechanism of protein folding. It is a monomericenzyme...
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Báo cáo khoa học: Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions docx
... HIF-1DNA binding and transcriptional activity. In this work, it is shown thatechinomycin strongly inhibits the activity of HIF-1 under hypoxic condi-tions, and also interferes with the activity of ... before the assay, and of HIF-1, c-myc and AP-1 transcriptional activity (reporter system) in the presence of 10 nM echinomycin.Dual effect of echinomycin on HIF-1 activity B. Vlaminck et al.5536 ... shown in Fig. 2, echinomycin, when added tonuclear extracts from hypoxic cells just before theassay, inhibited the DNA binding activity of c-myc byDual effect of echinomycin on HIF-1 activity...
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Báo cáo khoa học: The effect of heme on the conformational stability of micro-myoglobin doc
... 2007)doi:10.1111/j.1742-4658.2007.06176.xMicro-myoglobin, the isolated heme-binding subdomain of myoglobin, is avaluable model system for the investigation of heme recognition and bind-ing by proteins, and provides an example of protein ... of Arg45 and Lys96 (Fig. 8). These interactions conceiv-ably also contribute to the conformational stability of holo-lMb. Consistently, they are maintained over the1.5 ns of the simulation (Fig. ... and functional features of biological macromole-cules by providing details concerning intra- and intermolecular motions as a function of time. Although results of MD simulations do not alwaysand...
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Báo cáo khoa học: The effect of pH on the initial rate kinetics of the dimeric biliverdin-IXa reductase from the cyanobacterium Synechocystis PCC6803 pptx
... phycobilins to the corresponding rubin, areaction clearly catalysed in vitro [5], albeit with a rela-tively high Kmfor phycocyanobilin [5].Questions on the possible function of BVR-A in cyanobacteria ... changes in theprotein CD spectrum. Binding of biliverdin to sBVR-A is convenientlymonitored by following the induced CD spectrum for biliverdin. Binding of biliverdin to wild-type sBVR-A induces ... associated with anionizing residue that is involved in binding the 2¢-phos-phate of NADPH.The effect of pH on the initial rate kinetics is consis-tent with two ionizing groups in the enzyme active...
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Báo cáo khóa học: Identification of domains on the extrinsic 23 kDa protein possibly involved in electrostatic interaction with the extrinsic 33 kDa protein in spinach photosystem II ppt
... eight lysylresidues were identified to be modified with NSP, twoLys between Lys11 and Lys14; one Lys among Lys27 and Lys38; one Lys at Lys40; one Lys at Lys90 or Lys96; oneLys at Lys143 or Lys152; ... between Lys27 and Lys38; oneLys at Lys40; one Lys at Lys68 or Lys69; one Lys atLys90 or Lys96; one Lys at Lys143 or Lys152 and threeLys between Lys166 and Lys174 (Table 3). Ten residues in these ... to be Lys4, Lys20, Lys66–Lys76, Lys101, Lys105, Lys130, Lys159, Lys186 and Lys230–Lys236 by a combination of V8 protease digestion and MALDI-TOF MS of NSP or 2,4,6-trinitrobenzenesulfonic acid-modified...
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Báo cáo y học: "The Influence of Hyperbaric Oxygen Treatment on the Healing of Experimental Defects Filled with Different Bone Graft Substitutes"
... Istanbul, Turkey 3. Istanbul University, Faculty of Medicine, Department of Biochemistry, Istanbul, Turkey 4. Istanbul University, Faculty of Medicine, Department of Histology and Embryology, Istanbul, ... procedures in the oral and maxillofacial region. However, creation of a se-cond surgical site, prolonged operation time, donor site morbidity, inadequate bone volume and chronic pain ... Aktas5, Sinan Soley1 1. Istanbul University, Faculty of Dentistry, Department of Oral Surgery, Istanbul, Turkey 2. Istanbul University, Faculty of Medicine, Department of Oncologic Pathology, Istanbul,...
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