... [15–18]. Theseactin-binding activities are conserved in the EVH2domain [19,20]. On the other hand, the EVH1 domainbinds to proteins containing the consensus sequenceD ⁄ E FPPPPXD ⁄ E [21–23]. The ... protein binding. The presentstudy revealed that the EVH2 domain is the RAD51-binding domain. Minimal RAD51 binding wasobserved with EVL(1–221), which contains both the EVH1 and Pro-rich domains, ... stimulateshomologous pairing by RAD51.These new findings related to the recombinationactivities of the EVH2 domain suggest that the ENA ⁄VASP family proteins, which contain the EVH2domain at their C-terminus,...