... cerebrospinal fluid; LAMP-1, lysosome-associated membrane protein; RBP, retinol-binding protein; T3, 3¢,3, 5- triiodo-[L]-thyronine; T4, 3¢,5¢,3,5,-tetraiodo-[L]-thyronine; TBG, thyroxine-binding globulin; ... thyroid hormonesare 5¢,3¢,5,3-tetraiodo-[L]-thyronine (thyroxine, T4)and 3¢,5,3-triiodo-[L]-thyronine (T3). THs are synthe-sized by the thyroid gland and then secreted into thebloodstream (see ... oftransthyretin gene expression throughout evolution required the evolution of sophisticated families of tran-scription factors, co-modulator proteins and deiodinas-es, rendering transthyretin an excellent...