... anchor the protein to the membrane, as mutation of these cysteine residuesincreases the release of the BACE-1 ectodomain into the medium [13]. The stability and turnover of BACE-1, like that of the ... cathepsins B and D, and that cathepsin inhibi-tors may be therapeutically useful in AD [47,48].A recent study of the effect of glutaminyl cyclase inhi-bition on AD-like pathology in mouse and ... through the stress-activated protein kinase pathway [84]. The activation of cyclin-dependent kinase 5 also leads to increasedlevels of BACE-1 mRNA and protein in vivo and in vitro, and the BACE-1...