... inding proteins, 4E-BPs[4–8]); or with the scaffold proteins, eIF4GI and eIF4GII[1,4,5]. In vivo eIF4G exists partly in the form of a complexwith eIF4E and the ATP-dependent RNA helicase eIF4A,constituting ... eIF4A,constituting the initiation factor eIF4F (for reviews, see[1,9]). Within the sequences of eIF4GI and e IF4GII thereare domains that interact with eIF4E [8], eIF4A [9], eIF3[1,9,10]), the poly(A) ... inding of eIF4G to eIF4E an d the initiation of protein s ynthesis (for r eviews, see [1,5]). The heat shock protein (hsp), hsp25 can associate with the central domain of eIF4G following a severe...