... 0. 014 mmol, 14 %). 1 HNMRd 7.6–7.9 (m (16 H, P+–ArH and H -11 ),7.46(1H,s,H-6), 6.49 (1H, s,H-9),4 .1 4.2(2H,m,Ar-O-CH2), 3. 71 (3H, s, O-CH3), 3.4–4.0(5H,m,P+–CH2, H -11 a and H-3), 1. 75–2.4 ... replication and expression (Fig. 1) . For the DNAalkylating reagent we chose the antibiotic (11 aS)-8-hydroxy-7-methoxy -1, 2,3 ,11 a-tetrahydro-5H-pyrrolo[2 ,1- c] [1, 4]benzodiazepin-5-one; (DC- 81) [1, 25]. ... protein )1 range. There are 18 .7 · 10 9mtDNA moleculesÆmg mito-chondrial protein )1 [47] or about 6 .1 · 10 14 basesÆmgprotein )1 , 19 .3% of which are guanines corresponding to 1. 18 · 10 14 guanine...