Color Atlas of Pharmacology (Part 14): Drugs used in Hyperlipoproteinemias
Color Atlas of Pharmacology (Part 14): Drugs used in Hyperlipoproteinemias
... decreased or are even increased.High dietary intake may correlate with areduced incidence of coronary heartdisease.156 Drugs used in Hyperlipoproteinemias Lüllmann, Color Atlas of Pharmacology © ... conditions of license. Drugs used in Hyperlipoproteinemias 157Low systemic availabilityFluvastatinA. Accumulation and effect of HMG-CoA reductase inhibitors in liverInhibition of HMG-CoA ... lipids, as wellas the type of apolipoprotein, one dis-tinguishes 4 transport forms:154 Drugs used in Hyperlipoproteinemias Origin Density Mean sojourn Diameter in blood (nm)plasma (h)Chylomicron...
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Color Atlas of Pharmacology (Part 17): Drugs Acting on Motor Systems
... augmentingthe activity of intraspinal inhibitoryinterneurons. They are used in the treat-ment of painful muscle spasms, e.g., in spinal disorders. Benzodiazepines en-hance the effectiveness of ... conditions of license. Drugs Acting on Motor Systems 189A. Antiparkinsonian drugs SelegilineInhibition of dopamine degradationby MAO-B in CNSNormal stateDopamineAcetylcholineDopaminedeficiencyPredominance of ... dopamine in the corpus striatumand can be selectively inhibited by se-legiline. Inactivation of norepinephrine,epinephrine, and 5-HT via MAOAis un-affected. The antiparkinsonian effects of selegiline...
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Color Atlas of Pharmacology (Part 18): Drugs for the Suppression of Pain
... N-acetylcysteine, is givenintravenously within 6–8 h after inges-tion of an excessive dose of acetamino-phen. Whether chronic regular intake of acetaminophen leads to impaired renalfunction remains ... anesthetics)¼suppression of transmission of noci-ceptive impulses in the spinal me-dulla (opioids)¼inhibition of pain perception (opi-oids, general anesthetics)¼ altering emotional responses topain, i.e., pain ... as follows:¼elimination of the cause of pain¼lowering of the sensitivity of noci-ceptors (antipyretic analgesics, localanesthetics)¼interrupting nociceptive conduction in sensory nerves...
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Color Atlas of Pharmacology (Part 20): General Anesthetic Drugs
... (intubation). Administra-tion of the volatile anesthetic must thenbe titrated in such a manner as to coun-terbalance the waning effect of the in- jectable agent.Increasing use is now being ... made of injectable, instead of inhalational, an-esthetics during prolonged combinedanesthesia (total intravenous anesthe-sia—TIVA).“TIVA” has become feasible thanksto the introduction of agents ... appears to rule out involvement of specific receptors. According to one hy-pothesis, uptake into the hydrophobicinterior of the plasmalemma of neuronsresults in inhibition of electrical excit-ability...
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Color Atlas of Pharmacology (Part 23): Antibacterial Drugs
... gen-tamicin, tobramycin, amikacin, netilmi-cin, sisomycin). In addition, local inlays of a gentamicin-releasing carrier can be used in infections of bone or soft tissues.Aminoglycosides gain access ... synthesis5.RNADNAIncorrect:R: - I Idoxuridine- CF3 Trifluridine- C2H2 EdoxudineInsertion intoDNA instead of thymidineCorrect:ThymidineThymineDesoxyriboseIncorrect:Vidarabine Acyclovir ... 277A. Protein synthesis and modes of action of antibacterial drugs RibosomePeptide chainmRNAtRNAInsertion of incorrectamino acidAmino acidStreptomyces speciesTetracyclinesAminoglycosidesErythromycinChloramphenicolPeptidesynthetaseDoxycyclineTobramycinChloramphenicolErythromycinLüllmann,...
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Color Atlas of Pharmacology (Part 19): Local Anesthetics
... Metabolism of morphineNasalmucosa,e.g.,heroinsniffingIntravenousapplication"Mainlining"OralapplicationBronchialmucosae.g., opiumsmokingMet-Enkephalin Morphine FentanylHeroinOpioidMorphineNNCH2CH2COCH2CH3Tyr ... sug-gesting a binding site in apolar regions of the channel protein or the surround-ing lipid membrane.Mechanism-specific adverse ef-fects. Since local anesthetics block Na+influx not only in ... effectobtained with morphine or meperidine.The antagonist action of partial agonistsmay result in an initial decrease in effect of a full agonist during changeover tothe latter. Intoxication...
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Color Atlas of Pharmacology (Part 21): Psychopharmacologicals
... of GABA, binding to the receptors will,therefore, be increased, resulting in anaugmented response. Excitability of theneurons is diminished.Therapeutic indications for benzo-diazepines include ... disorder(i.e., distracted, incoherent, illogicalthinking; impoverished intellectualcontent; blockage of ideation; abruptbreaking of a train of thought: claims of being subject to outside agencies ... degradation of serotonin and norepinephrine causes anincrease in extracellular amine levels. Apsychomotor stimulant thymeretic ac-tion is the predominant feature of MAOinhibitors. An older member of...
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Color Atlas of Pharmacology (Part 22): Hormones
... curvesA. Insulin productionS - SS - SAla Thr30Porcine insulin Human insulinInsulinB-chainA-chainProduction: DNAE. coliHours after injection6 12 18 24IntermediateSlowInsulinmixturesInsulin ... 24IntermediateSlowInsulinmixturesInsulin suspension = protamine zinc insulin Insulin solution = regular insulinInsulin concentration in bloodRapidLüllmann, Color Atlas of Pharmacology © 2000 ThiemeAll ... C-terminal alanine in the B chain of porcine insulin; or by gene technologyinvolving insertion of the appropriatehuman DNA into E. coli bacteria.Types of preparations (B). As apeptide, insulin is...
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Tài liệu Color Atlas of Pharmacology (Part 24): Disinfectants ppt
... bymechlor-ethamineInsertion of daunorubicin,doxorubicin,bleomycin,actinomycin D, etc.Streptomyces bacteriaInhibition of nucleotide synthesisPurinesThymineNucleotideTetrahydro-folateDihydrofolateReductaseFolic ... synthesisPurinesThymineNucleotideTetrahydro-folateDihydrofolateReductaseFolic acidInhibition byPurine antimetaboliteInsertion of incorrect building blocksPyrimidine antimetabolite6-Mercaptopurinefrom AzathioprineAdenineUracilCytarabine Cytosine CytosineDesoxyriboseinstead ... iodine-re-leasing agents like polyvinylpyrrolidone[povidone, PVP]-iodine as a depot form of the active principle iodine, instead of iodine tincture), cationic surfactants,and mixtures of these....
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Tài liệu Color Atlas of Pharmacology (Part 25): Therapy of Selected Diseases pptx
... adverseeffects of colchicine are abdominal pain,vomiting, and diarrhea, probably due toinhibition of mitoses in the rapidly di-viding gastrointestinal epithelial cells.Colchicine is usually ... mechanisms of action, inhibition of macrophage activ-ity and inhibition of release or activity of lysosomal enzymes are being dis-cussed. Included in this category are:sulfasalazine (an inhibitor of ... O2-wasting effect of sympa-thetic drive by inhibiting β-receptor-mediated increases in cardiac rate andspeed of contraction.Uses of antianginal drugs (D). Forrelief of the acute anginal attack,...
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