... (i.e. on/off switch-ing with/without hormone) has been demonstrated experi-mentally using both in vitro and cell-based assays [6,7].NRs make use of chromatin to apply an exquisite levelof transcriptional ... including a highly conservedDNA-binding domain, a C-terminal ligand-bindingdomain, and two transcriptional activation functions (anN-terminal AF-1 and a C-terminal AF-2) (Fig. 1) [1,2]. Thetwo ... MINIREVIEWNuclear receptor-dependent transcription with chromatinIs it all about enzymes?W Lee Kraus1,2and Jiemin Wong31Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY,...