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Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"

Báo cáo y học:

Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"

... up-regulated at the early stage of atherosclerosis. Losartan (an angioten-sin-converting enzyme inhibitor) could reduce neointima proliferation and down-regulate the elevated protein expression of ... Effects of Losartan on expression of connexins at the early stage of athe-rosclerosis in rabbits Li-ming Ruan, Wei Cai, Jun-zhu Chen, Jin-feng Duan The First Affiliated Hospital, College of Medicine, ... were markedly reduced by treatment. RT-PCR and Western blot assay showed that the mRNA and protein expression of Cx40 and Cx43 were elevated in the neointimal area at the early stage of atherosclerosis. ...
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Báo cáo y học:

Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"

... response to p-synephrine or p-synephrine in combination with naringin and hes-peridin (Table 2). p-Synephrine differs from ephedrine in that it has a hydroxyl group on the para position of ... were randomly assigned to one of the five dou-ble-blinded treatment conditions in which they con-sumed one ounce of V-8 juice containing the following ingredient variations: Group ... mechanism by which naringin and hesperi-din increase the thermogenic effect of p-synephrine may involve enhancing the expression of adiponectin which is known to play a role in lipid...
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Báo cáo y học: "Effects of Flurbiprofen on CRP, TNF-α, IL-6, and Postoperative Pain of Thoracotomy"

... release of both proinflammatory and antiinflammatory proteins. Proinflammatory cy-tokines induce not only a local inflammation at the site of injury, but also systemic responses ... antiinflammatory drugs (NSAIDs) are useful in pain states, and work by inhibiting the cyclooxygenase enzyme responsible for the release of mediators of inflammation (6). The aims of this ... often used method for evaluating variations in pain intensity. Subjects are instructed to indicate the intensity of the pain by marking a 100-mm line anchored with terms describ-ing the...
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Báo cáo Y học: Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells docx

Báo cáo Y học: Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells docx

... antibody bindingthroughout the catalytic cycle including the step of ATPbinding, to become unavailable only in the catalytictransition state. ATP hydrolysis could cover the energyexpenses of ... alternatively, the CsA-typedrugs may induce a special conformation adopted by Pgponly in the presence of these drugs. The first possibilitywould be confirmed if the same conformational state couldbe ... changes in UIC2 reactivity are accompanied bycomplementary changes in MM12.10 binding also in re-sponse to direct modulation of the ATP-binding site, con-firming that conformational changes intrinsic...
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Báo cáo y học:

Báo cáo y học: "Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators"

... study and takes responsibility for theintegrity of the data and the accuracy of the data analysis. MK contributed tostudy concept and design, to analysis and interpretation of data and to draft-ing ... Consideration of the influence of appro-priateness of empiric therapy against subsequently identi-fied pathogens was beyond the scope of this economicanalysis and merits further evaluation .The ... NK of Johnson and Johnson met authorship criteria by participating in the study design, analysis of results, interpretation of findings, and drafting of the paper.Independent statistical analysis....
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Báo cáo y học:

Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&

... socialinteractions since beginning the study medication, and91.9% were satisfied with the efficacy of the study medi-cation on their child's attention. The majority of caregiv-ers (93.1%) indicated ... indicated a high level of satisfaction with theduration of effect of the study medication on their child'sADHD symptoms.Regarding medication satisfaction with tolerability ofMTS, at study endpoint ... over the course of the study. At baseline, mostcaregivers indicated inconsistency in their child's behavioracross the day in contrast to endpoint where the majorityreported consistency in...
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 Báo cáo y học:

Báo cáo y học: " A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women"

... many including the World Health Organization (WHO) [12,13]. Strategies to lose body fat typically involve a combination of dietary changes limiting caloric intake, increased physical activity, ... circum-stances. Upon completion of the study, the envelope was opened in the presence of a representative of the sponsor and of the Principal Investigator, and the representative formulas of the samples ... slowing of the rapid absorption of carbohydrates would favorably influence the insulin system that could, in turn, lead to lesser fat accumulation [27]. We have previously shown in a rat model the...
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Báo cáo y học:

Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

... associated with the low risk of the infection independent on severe atrophy. Although the Gab1 polymorphism prevented H. pylori infection, it was associated with the risk of atrophy identified as the ... apparently H. pylori-negative subjects were indeed truly negative or they eventually led to loss of the infection due to sever gastric atrophy. Because, in our study, gastric atrophy and H. pylori infection ... phosphopeptides that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc

Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc

... min21 at 0.05, 0.5, and2.5 mg·mL21enzyme, respectively) indicate that BLXIinactivation is slightly dependent on concentration, withBLXI stability increasing with enzyme concentration. At ... activates BLXI on glucose and on xylose, the apoenzyme activity was tested on both sugars in the presence of increasing concentrations of each cation (in the chloride form; Fig. 4). In the absence ... increasefrom the apoenzyme to the Mn2þ-containing enzyme, loss of the metal cofactor could be the limiting step in BLXIinactivation. Higher Eavalues of inactivation for the Co2þ–enzyme and the...
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Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

... translational machinery, the common feature being that they cause dephosphorylation of 4E-BP1 and thus inhibition of eIF4E. In addition toproviding further information on the regulation of anumber ... components of the translational machinery, principally by changes in theirphosphorylation, leading to modulation of their activities ortheir abilities to interact with one another [1,2].Initiation ... translationalmachinery.Keywords: stress; initiation; elongation factor; mRNAtranslation; S6 kinase. The control of mRNA translation in mammalian cellsinvolves the regulation of a range of components...
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