Báo cáo y học: " Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis"
Báo cáo y học: " Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis"
... hepatic < /b> steatosis < /b> in < /b> HBeAg-negative < /b> chronic < /b> hepatitis < /b> B (CHB) patients and their diagnostic values in < /b> hepatic < /b> inflammation and fibrosis. Methods: A total of < /b> 106 HBeAg-negative < /b> CHB patients with clinically ... prevalence of < /b> obesity and insulin resistance in < /b> this ethnic group (3). But, that how does hepatic < /b> steatosis < /b> influence CHB still re-mains unclear (4), particularly in < /b> HBeAg-negative < /b> CHB patients. In < /b> contrast, ... shown in < /b> Table 4. TG, GGT, Glb, and FINS were all associated with hepatic < /b> inflammation in < /b> each stage among HBeAg-negative < /b> CHB patients, but only FINS and Glb were strong predictors < /b> tested by likelihood...
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Báo cáo y học: "Identification of Cellular Membrane Proteins Interacting with Hepatitis B Surface Antigen using Yeast Split-Ubiquitin System"
... characterization of < /b> membrane protein interactions to overcome this limitation [6-8]. In < /b> this system, the ubiquitin is split into N-terminal ubiquitin (Nub) and C-terminal ubiquitin (Cub) but the Nub and Cub ... of < /b> yeast two hybrid system, which is a genetic assay for in < /b> vivo detection of < /b> interactions of < /b> proteins, enables identification of < /b> protein-protein interactions between a soluble bait and its interacting ... that interact with HBsAg and thereby contributing to HBV morphogenesis. Using the yeast split-ubiquitin system, a number of < /b> cellular membrane proteins have been isolated in < /b> this study. These include...
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Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"
... significantly more likely toreturn to clinic than those not on ART. Members of < /b> tribes targeted by violence and members of < /b> minoritytribes were less likely to return. In < /b> qualitative analysis of < /b> 9 key informant ... University School of < /b> Medi-cine and Moi Teaching and Referral Hospital (Eldoret,Kenya) and the Institutional Review Board of < /b> the IndianaUniversity School of < /b> Medicine (Indianapolis, Indiana).Informed ... to increase the credibility of < /b> the results. Investigatortriangulation was used by involving additional investiga-tors in < /b> reviewing the recordings and field notes and inconfirming or disconfirming...
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Báo cáo Y học: Properties of the Na+/H+ exchanger protein Detergent-resistant aggregation and membrane microdistribution potx
... saturatedphospholipids and some specific proteins [34,35]. Thefunction of < /b> such subdomains of < /b> the membrane proteinsmay be to aid in < /b> targeting, and possibly to aid in < /b> signalingby localizing specific receptors ... Na+/H+exchanger remained in < /b> the Triton X-100insoluble fraction.The Na+/H+exchanger has been reported to be linkedto the cytoskeleton possibly providing a link between actinbinding proteins and the ... proven difficultbecause of < /b> its low abundance and because of < /b> the difficulty in< /b> overexpressing integral membrane proteins. In < /b> this study,we examined the behavior of < /b> the protein expressed in< /b> mammalian...
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Báo cáo Y học: Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo potx
... development of < /b> obesityby both, increasing energy expenditure and d ecreasing in < /b> situlipogenesis. In < /b> order to further analyse consequences of< /b> respiratory uncoupling in < /b> white fat, the eects of < /b> the ... 3¢,3¢-diaminobenzidinehydrochloride c hromogen (Sigma). The speci®city of < /b> themethod was tested by the omission of < /b> the primary antibody in < /b> the staining, and the use of < /b> p reimmune serum instead of< /b> the ... Ivo SyrovyÂ1, Saverio Cinti2 and Jan KopeckyÂ11Department of < /b> Adipose Tissue Biology and Center for Integrated Genomics, Institute of < /b> Physiology,Academy of < /b> Sciences of < /b> the Czech Republic,...
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Báo cáo khoa học: Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria doc
... assembly of < /b> the holoenzyme.Results In < /b> vitro import and assembly of < /b> nDNA-encodedcomplex IV subunitsThe assembly of < /b> a number of < /b> nDNA-encoded com-plex IV subunits was investigated by importing ... important step in < /b> the biogenesis of < /b> these subunits and subsequently the holoenzyme.Assembly analysis of< /b> 35S-labeled Cox6a in < /b> patientmitochondriaThe assembly of < /b> subunit Cox6a was investigated ... absence of < /b> a membrane potential (Dwm). Each samplewas treated with proteinase K before being solubilized in < /b> digitonin-containing buffer and subjected to BN-PAGE and phosphorimaging. (B) 35S-labeled...
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Báo cáo khoa học: Expression of heme oxygenase-1 is repressed by interferon-c and induced by hypoxia in human retinal pigment epithelial cells pot
... cells, indicating that Bach1 may notbe a key determinant for the hypoxia-mediated induction of < /b> HO-1 expression in < /b> D407 cells. In < /b> addition, hypoxiacoordinately and rapidly induced expression of < /b> both ... hypoxiainduces the expression of < /b> HO-1 in < /b> human dermal fibroblastsby increasing the half-life of < /b> HO-1 mRNA [51]. I n humandermal fibroblasts, the induction was inhibited by cyclo-heximide and peaked ... RPE cells by hypoxiaHO-1 protein levels were increased by hypoxia in < /b> D407RPE cells by 12 h and 24 h, as judged by Western blotanalysis (Fig. 3). In < /b> contrast, hypoxia had no noticeableeffects...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... labeling of < /b> the glycogen C2 and C5 resonancedue to label scrambling from pyruvate carboxylase/phos-phoenolpyruvate carboxykinase activity (Ôpyruvate recyc-lingÕ), the intensity of < /b> glycogen C4 ... 6-phosphofructo-1-kinase/fructose-1,6-bisphospha-tase cycle. The result must be interpreted with care,however, as both glycolysis and glycogen synthesis havebeen shown to be in< /b> uenced by substrate channeling and protein–protein ... during infusion of < /b> [1-13C]glu-cose, label incorporation was observed not only into the C1 of < /b> glycogen but also the C6, which can only occur by labelscrambling at the level of < /b> the trioses. In...
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Báo cáo Y học: Implications of the simultaneous occurrence of hepatic glycolysis from glucose and gluconeogenesis from glycerol pdf
... from[U-14C]glycerol were examined in < /b> isolated hepatocytes fromfasted rats. A 5 mMbolus of < /b> glycerol inhibited phosphory-lation of < /b> 40 mMglucose by 50% and glycolysis by more than60%, and caused ... carbohydratemetabolismThese initial studies indicated the desirability o f m aintaininglow c oncentrations of < /b> glycerol in < /b> the incubatio n medium.Because t his substrate is rapidly metabolized by ... data.RESULTSEffects of < /b> a bolus of < /b> glycerol on hepatic < /b> carbohydratemetabolism In < /b> initial studies, hepatocytes from fasted rats wereincubated with 40 mM[6-3H]glucose in < /b> the absence orpresence of < /b> a bolus of...
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Báo cáo y học: " Implementation of a new emergency medical communication centre organization in Finland an evaluation, with performance indicators"
... prolongation in < /b> theanswering and processing times of < /b> emergency calls inHelsinki, the capital of < /b> Finland [5].EMCC organization and EMD in < /b> Finland - before and nowThere used to be 45 municipality-based ... Handbooks of < /b> the Ministry of < /b> Social Affairs and Health Ambulance andemergency care services: A handbook for drawing up an alarmprocedure. Finland Helsinki; 2005, 56.7. Kuisma K, Boyd J, Väyrynen T, ... implementation of < /b> a new EMCC organization in < /b> Finland the percentage and number of < /b> highpriority calls increased. There was a trend, but no statistically significant increase in < /b> the emergency medicaldispatchers’...
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