Báo cáo y học: "Relationship between Anti-CCP Antibodies and Oxidant and Anti-Oxidant Activity in Patients with Rheumatoid Arthrit"
Báo cáo y học: "Relationship between Anti-CCP Antibodies and Oxidant and Anti-Oxidant Activity in Patients with Rheumatoid Arthrit"
... anti-CCP antibodies in the circu-lation on whole blood, serum and synovial fluid oxidant and anti -oxidant activity in patients with RA. Materials and Methods: RA patients with anti-CCP (+) (n=25) and ... (oxidative activity) , between the pa-tients with anti-CCP( +) and those with anti-CCP( -). There was increased synovial oxidant activity (MDA and MPO levels) (p<0.05) in anti-CCP( +) RA patients with ... relationship between anti-CCP antibodies and oxidant, anti -oxidant activity in patients with RA has not been elucidated in the previous studies. In this study we aimed to investigate the effect of anti-CCP...
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Báo cáo y học: " Relationship between anal symptoms and anal findings"
... patients with only one BAD. The spectra of symptoms in these patients suggest that they have more than one BAD to diagnose and to treat [3,12,24,29]. Interestingly our patients with BAD and without ... and anal soreness (p=0.006). Table 9: Types and frequencies of symptoms and signs specified by patients with BAD and individuals without BAD. Nominations are presented since participants stand ... treatment modalities for patients complaining of anal and/ or abdominal symptoms and having BAD vs. individuals without BAD 260 patients with BAD* N (%) 125 individuals without BAD** N (%) Pearson...
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Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx
... 2005)doi:10.1111/j.1742-4658.2005.04736.xThe binding of several alkyl- and aryl-guanidines and N-hydroxyguanidinesto the oxygenase domain of inducible NO-synthase (iNOSoxy) was studiedby UV ⁄ Vis difference spectroscopy. In a very ... the oxygenase domain of iNOS (iNOSoxy) with various alkyl- and aryl-guanidines and N-hydroxygua-nidines were determined by UV ⁄ Vis difference spectros-copy, according to a previously described ... oxidation of manynon-a-amino acid monosubstituted N-hydroxyguani-dines, including N-alkyl-N¢-hydroxyguanidines and N-aryl-N¢-hydroxyguanidines, provided that the alkylor aryl substituent is...
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Báo cáo Y học: Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity docx
... orientation, and specificity of thisdomain, with residues Tyr91 and Tyr137 forminginteraction pocket 1; Tyr93, Tyr137 and Trp119 form-ing pocket 2, and the valley between n-Src and RTloops included by ... sub-sequently allows binding of the Fyn SH2-domain toPAG Tyr163 or pTyr181 and results in a dual-domaindocking, enhancing the affinity of the Fyn–PAG inter-action and rendering Fyn insensitive to ... the interaction is highly dependenton phosphorylation performed by the Src family kinase Fyn, which docksonto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn. In...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf
... replaceCys189 with Ser, and thus increasing the stability of theprotein and eliminating the possibility of isoprenylation.Recombinant Rac1 protein was expressed in E. coli as afusion protein with ... chroma-tography was then used to purify PAK68. The autophos-phorylation and kinase activity of PAK were stimulated bybinding to activated Rac/Cdc42, which thereby directlymodulates the enzyme activity ... Rac-activatedprotein kinase (PAK) during the differentiation of HL-60induced by all-trans-retinoic acid (ATRA). Manser et al.[7]have isolated a brain protein kinase, PAK68, by purifying aprotein with Rac1/Cdc42-GTP...
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Báo cáo y học: "Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk – A Meta-Analysis"
... encoding chemokines rantes and mcp-3 in symptomatic atopic and nonatopic asthmatics: Relationship to the eosinophil-active cytokines interleukin (il)-5, granulocyte macrophage-colony-stimulating ... generated by T lymphocyte, is one of the most extensively studied C-C chemokines in allergic inflammation[6]. RANTES is likely to be important in airway inflammation be-cause blocking antibodies ... associated with significantly increased risk of asthma (GG+CG vs CC: OR=1.24, 95%CI=1.08-1.41) without any be-tween-study heterogeneity. In the stratified analysis by asthma type, age and ethnicity,...
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Báo cáo y học: "Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome"
... 3.0) with or without low-dose aspirin (75 mg/day) was significantly more effective than low-intensity war-farin (INR under 3.0) with or without low-dose aspi-rin, or treatment with aspirin alone, ... Satisfactory results have not yet been obtained in therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome (APS). We therefore compared single antiplatelet therapy and ... dis-turbed in patients with APS [17]. Since protein C is closely associated with factor VIII and factor V, this result suggests that the coagulation system is im-paired in patients with APS, and so...
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Báo cáo y học: "Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease"
... as a spin trap. The stable ni-troxide radical 2-ethyl-2,4,4-trimethyloxazolidine--3-3-yloxy (OXANO•) was reduced to the hydroxyl-amine spin trap 2-ethyl-3-hydroxy-2,4,4--trimethyloxazolidine (OXANOH) ... Conclusions: The main finding in our study is that MMP-9 in plasma is asscociated with radical production dur-ing carotid endarterectomy, suggesting that this enzyme might be involved in the pathogenesis ... by these proteinases occurs during progression of atherosclerosis [22]. Furthermore, an increase in MMP activity occurs after stroke, which contributes to is-chaemic brain injury, including infiltration...
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Báo cáo y học: "Discriminating between elderly and young using a fractal dimension analysis of centre of pressure"
... remain standing upright. Difficulty lies in deciphering the information contained within these traces and distinguishing one from the other. However, with recent advances in the area of chaos and ... fractal dimension type of analysis can be incorporated into clinical testing to identify patients with pathologies. KKeeyy wwoorrddss dynamical systems, quiet stance, non-linear, control, balance ... dimension analysis of COP in A/P direction. ^ indicate a significant difference between young and elderly in the eyes closed condition; * indicate a significant difference between eyes open and eyes closed...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... l-lysine, l-serine, b-alanine, taurine, sarcosine,dimethylglycine, glycine betaine, trimethylamine N-oxide, and cytidine 2¢-3¢ cyclic monophosphate were also obtainedfrom Sigma. These and other ... and amino acids and derivatives(glycine, alanine, proline, serine, lysine, b-alanine and taurine) that have no significant effects on both DGD° and kcat. (b) Class II represents methylamines ... well proteinstability and activity are coupled in the presence of anosmolyte. This study was undertaken to investigate therelationship between protein stability and activity changes in the presence...
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