Báo cáo y học: "Positioning Effects of KillerRed inside of Cells correlate with DNA Strand Breaks after Activation with Visible Light"
Báo cáo y học: "Positioning Effects of KillerRed inside of Cells correlate with DNA Strand Breaks after Activation with Visible Light"
... increase of fluorescence in-tensity inside of the nuclei of DU145 cells. Figure 2 visualizes the degree of the DNA damage in nuclei as a result of DNA strand breaks caused by ROS produced by the ... toxicity by measurements of DNA- strand breaks in cell-c lo ne s stably transfected with plasmids expressing KillerRed proteins (e.g. pKillerRed-Lamin B1) after activation with white ... exposed to highly reactive ROS which induce single strand breaks in the DNA. In cells, generally, these toxic effects are eliminated by repair enzymes. Poly-(ADP-ribose)-polymerases (PARP)...
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Tài liệu Báo cáo Y học: The effects of ring-size analogs of the antimicrobial peptide gramicidin S on phospholipid bilayer model membranes and on the growth of Acholeplasma laidlawii B ppt
... behavior of LMVs composed of dimyristoylglycerophosphocholine (Myr2Gro-PCho), dimy-ristoylglycerophosphoethanolamine (Myr2Gro-PEtn) anddimyristoylglycerophosphoglycerol (Myr2Gro-PGro) byDSC, ... rmcelhan@gpu.srv.ualberta.caAbbreviations: GS, gramicidin S; Myr2Gro-PCho, dimyristoylglycerophosphocholine; Myr2Gro-PEtn, dimyristoylglycerophosphoethanolamine;Myr2Gro-PGro, dimyristoylglycerophosphoglycerol; DSC, differential ... studies of the interaction of GS and its analogs with bacterial cells that the destruction of the integrity of the lipid bilayer of the inner membraneis the primary mode of antimicrobial action of...
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Tài liệu Báo cáo Y học: The effects of low pH on the properties of protochlorophyllide oxidoreductase and the organization of prolamellar bodies of maize (Zea mays) pot
... Deyashiki, Y. , Hara, A.& Mitsui, Y. (1998) Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A˚resolution: the structuralorigin of coenzyme specificity in ... Zhang,L.,Ahvazi,B.,Szitner,R.,Vrielink,A.&Meighen,E.(1999) Change of nucleotide specificity and enhancement of cat-alytic efficiency in single point mutants of Vibrio harveyi aldehydedehydrogenase. Biochemistry 38, 11440–11447.33. Busch, ... the sensitivity of spectral changes to the presence of adenyl nucleotidesmay reflect their effects on NADPH binding rather thantheir effects on specific phosphorylation (or adenylation)steps.ACKNOWLEDGEMENTThe...
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Tài liệu Báo cáo Y học: Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils pot
... activation, most of this AA is replaced byother fatty acids. Finally, because cell activation isaccompanied by an increase in PAF biosynthesis viaacetylation of 1-alkyl-2-lyso-GPC by acetyl ... transacylation activity toward lysopho-sphatidic acid catalyzed by acyl-coenzyme A: lysophosphatidicacid acyltransferase. J. Biol. Chem. 276, 26745–26752.50. Wykle, R.L., Blank, M.L. & Snyder, F. (1973) ... formation of 1-alk-1-enyl-2-lyso-GPE. Wykle and colleagues haveshown that 1-alk-1-enyl-2-lyso-GPE enhances PAF for-mation by a CoA-IT-dependent generation of lyso PAF[55].Thus,whilePLA2isotypes...
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Báo cáo Y học: Tyrosine sulfation and N-glycosylation of human heparin cofactor II from plasma and recombinant Chinese hamster ovary cells and their effects on heparin binding pot
... the trypan blue exclusion assay a nd thespecific HCII productivity (lgper106 cells per day) wascalculated.Treatment of HCII expressing CHO cells with inhibitors of N-glycosylation and tyrosine ... ham-ster ovary cell-derived HCII was detected in > 9 0% of the diantennary and triantennary glycans, the latterbeing slightly less sialylated with exclusively a2 fi 3-linkedN-acetylneuraminic ... heparin–Sepharose, indicating that tyrosinesulfation and N-linked glycans may affect the inhibitor’sinteraction w ith g lycosaminoglycans.Keywords: heparin cofactor II; glycosylation; tyrosinesulfation; heparin...
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Báo cáo y học: "Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units"
... T-helper lymphocyte type 2cytokine activation in response to sepsis after traumatic injury.Eosinophils normally account for only 1% to 3% of peripheralblood leucocytes, and the upper limit of the ... micro-biologically documented in 58% of cases; this low percentagemay be explained by the frequency of respiratory tract infectionin our study (60% of cases), because microorganisms are notusually isolated ... mortality.Unfortunately, the availability of a highly specific sensitivemarker of infection is still not satisfied [4]. An ideal marker ofinfection would be highly specific, highly sensitive, easy tomeasure,...
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Báo cáo y học: "Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients"
... experienced bythe third patient randomly assigned to DIS may be explainedby withdrawal symptoms.Based on the results of our study, DIS may not be the sedationstrategy of choice in all mechanically ventilated ... developed hypertension and subsequent tachycardia,tachypnea, and patient-ventilator asynchrony. Treatment withsedatives led to resolution of the hypertension and tachycar-dia, but the tachypnea and ... minimizing the symptoms of withdrawal duringsedation interruption [32]. The assessment of withdrawal syn-dromes rests principally on patient self-reporting of subjectivesensations of irritability, nausea,...
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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
... initiating treatment withantipsychotics. However, a careful medical history shouldbe taken for symptoms of cardiac pathology, such asrecurrent syncope. A family history of early sudden deathshould ... organ involvementwith onset of symptoms within 1 to 8 weeks of exposure.The frequency of the syndrome is estimated at 10–100 per100,000 persons exposed. Risk of serious hypersensitivityreactions among ... increased bioavailabil-ity of free, active highly protein-bound drugs. Accumula-tion of active hydroxylated metabolites of carbamazepinemay lead to symptoms of drug toxicity despite therapeuticdrug...
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Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"
... analysis of sol-id-pseudopapillary tumor of the pancreas: report of 15 cases. Hepatobilliary Pancreat Dis Int. 2008;7(2):196-200. 10. Yu CC, Yeh CN, Hwang TL, Jan YY. Clinicopathological study ... Microscopically the tumor was composed of nests of epithelial cells with a solid pseudopapillary cystic and trabecular pattern, which demonstrated the characteristics of SPT histologically. At ... usually demonstrate a huge, well-encapsulated mass with both solid and cystic components and displace-ment of nearby structures.15,17 Additionally, CT can play much more important role by...
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Báo cáo y học: " Rationale for one stage exchange of infected hip replacement using uncemented implants and antibiotic impregnated bone graft"
... account the issue of bacterial phenotypes inside biofilms. Sonication of explanted devices may dis-lodge adherent biofilms, culturing the sonication fluid is likely to raise sensitivity of cultures ... disrupted from biofilms that may be the cause of recurrence after an indefinite period of time. Fragments of biofilms seem to be more vulnerable for antibiotics compared with intact biofilm systems 21,22 ... dealing with freely floating bacteria. Planktonic bacteria may well be eliminated by conventional use of antibiotics, however, in ODRI we have to deal with phenotypically different forms of bacteria...
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