Báo cáo y học: "Spindle Cell Lipoma of the Hypopharynx"
Báo cáo y học: "Spindle Cell Lipoma of the Hypopharynx"
... Key words: Dysphagia, Head and Neck, Adult, Diagnosis, Spindle Cell Lipoma, Hypopharyngeal lipoma Introduction Lipomas are the most frequently observed soft tissue tumors in adults. They ... origi-nating from the mature lipid tissue1. They constitute approximately 0.6% of the laryngeal and hypopha-ryngeal benign tumors4. Laryngeal and hypopharyn-geal lipomas first appeared ... Di-agnosis is often difficult due to indistinct symptoms5,7. In this case, the feeling of a mass in the throat without dysphagia was the only symptom of large pyriform sinus lipoma. The preferred...
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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
... cells. By the age of 8 years, the top of the frontal sinuses is at the level of the orbital roof, and by the age of 10 years, the sinuses extend into the vertical portion of the frontal ... By the age of 4 years, the average cranial extent of the frontal sinus reaches half the height of the orbit and extends just above the top of the most-anterior ethmoid cells. ... craniotomy because of the proximity of the sinus to the orbit and the anterior skull base [5]. The frequency of bilateral absence of the frontal sinus has been reported in 3-4% to 10% of ...
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Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx
... to the antibody [18].Conventional pepscan analysis however, does not alloweasy analysis of the contribution of the carbohydrateportion. To assess the involvement of carbohydrates inantibody ... residue and/or by the binding contribution fromtheGalNAcresidue.Docking the glycopeptide to the antibody the sugar ringhas little contact to the protein surface. Only the N-acetylmethyl group is ... interactions of Pro1 and the GalNAc N-acetyl methyl group with the antibody. The differences between amino acids are less pronounced than incase of the unglycosylated peptide indicating that either the glycopeptide...
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Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... the phosphorylation of UTP and hydrolysis of glutamine foroptimal efficiency in CTP synthesis rather than just acting toincrease the rate of glutamine hydrolysis itself.Keywords: CTP synthase; isothermal ... that if the role of GTP wassolely to increase the rate of glutamine hydrolysis, therewould have been no effect of adding GTP when the rate of CTP synthesis was limited by the concentration of nucleotide ... activity, (B) CTPsynthesis in the absence of GTP and (C) CTP synthesis in the presence of GTP. (A) Glutamine hydrolysis in the absence of nucleotides takesplace on the enzyme without any large...
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Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx
... 2-arachidonoylglycerol (2-AG), the cannabinoid CB1and CB2receptors, and one of the enzymes mostlyresponsible for endocannabinoid hydrolysis, the fatty acidamide hydrolase (FAAH). By using a very ... on the basis of the sequence of the FAAH gene (NCBIaccession number AF098010) by including the introns5476–6026 and 6173–6296, and of the sequence of the glyceraldehyde-3-phosphate dehydrogenase ... oligonucleotides were synthesized on the basis of cloned human cDNA sequences of glyceralde-hyde-3-phosphate dehydrogenase, FAAH, CB1and CB2.For glyceraldehyde-3-phosphate dehydrogenase, the prim-ers...
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Báo cáo Y học: Osmoregulated periplasmic glucans of the free-living photosynthetic bacterium Rhodobacter sphaeroides doc
... linkage; and (c) they are highly substituted bysuccinyl and acetyl residues. They also exhibit some degree of structural rigidity as demonstrated by the distinctchemical shifts values of all anomeric ... recently demonstrated, in the case of E. chrysanthemiinfection, that OPGs are necessary within the cell [7]. Wecan draw a parallel between OPGs and lipid A of the lipopolysaccharide. The primary ... [19,20] synthesize OPGs that havea unique degree of polymerization (13 and 16, respectively).They are cyclic, and are linked by b-1,2 glycosidic bonds andone a-1,6 glycosidic bond. These glucans...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... alonedid not significantly change the sensitivity of the cells to any of the cytokines. Transfection of both gp130c and LIFR ledto a prominent response of the cells to all three cytokines.No STAT1-activation ... the disintegration of the cells (data notshown). Because of the high expression levels of the transiently transfected receptors in COS7 cells, they wereused for the analysis of dimerization between ... expressedtogether with the LIFR in COS7 cells. In a previous report[15], we established a system that allows the study of gp130mutants together with the LIFR in COS7 cells despite the presence of low...
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Báo cáo Y học: Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein doc
... staining of the cytosol and the nucleoli of trans-fected cells was less intensive. These data provide strongevidence for a nuclear localization of nicolin 1 regardless of the mode of fusion with the ... detailedanalysis of the expression of the Nicn1 gene at days 8.5, 9.5,and 10.5 of murine development was performed by in situhybridization of digoxigenin-labeled riboprobes to whole-mount mouse embryos. ... In human, dog and mouse the NICN1 gene is immediately followed by the AMT genefor aminomethyltransferase, an enzyme of glycine meta-bolism [4,11]. The promoters of the canine and murineNICN1...
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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... of the receptors was confirmed byimmunoblotting of the cell lysates (Fig. 1B). As oftenobserved for membrane proteins, the bands were ratherbroad in the blots, due to the heterogeneity of the ... of the receptor [19,22]. The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ligand binds to domain III of the receptor. Recently,Gly441 of the ErbB-1 domain III was ... of ERKactivation resulting from the amplifying effect of the signaling cascade.DISCUSSIONIn the present study, by using chimeric receptors, the contributions of the extracellular domains of...
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Báo cáo Y học: Thermodynamics and kinetics of the cleavage of DNA catalyzed by bleomycin A5 A microcalorimetric study pdf
... investigations of the scission of calf thymus DNA catalyzed by bleomycin A5(BLM-A5) in the presence of ferrous ion and oxygen. The molar reaction enthalpy for the cleavage, the Michaelis–Menten ... respectively, at 37.0 °C. This DNA cleavage was alargely exothermic reaction. The catalytic efficiency of BLM-A5is of the same order of magnitude as that of lysozyme butseveral orders of magnitude ... underestimating of the cleaving potential of the remaining molecules. The impact of self-inactivation of activated BLM on the thermodynamics of DNA binding ismore complex. As the structural identities of the...
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