... Bacterial IscU is a well folded and functional single domain proteinSalvatore Adinolfi1, Francesca Rizzo1, Laura Masino1, Margie Nair1, Stephen R. Martin1, Annalisa Pastore1and ... here a structural characterization of thisprotein and demonstrate that E. coli IscU can be obtainedas a recombinant well- folded protein. We demonstrate thatour construct can function as a scaffold ... offrataxin, a small protein expressed at abnormally low levelsin Friedreich’s ataxia patients [7]. Consistent evidence showsthat Friedreich’s ataxia arises from disregulation of mito-chondrial...