... 2003).Once GVHD is initiated, T-cells produce additional proinflammatory cytokines, including tumor necrosis fac-tor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-2, which in turn attract ... Consensus recom-mends a system for scoring chronic GVHD manifestations in organs and sites, including the skin, mouth, eyes, gastro-intestinal tract, liver, lungs, joints and fascia, genital tract, ... scaly; the skin may heal by scarring; hair loss may accompany the skin injuryEyes and mouth Look for dry eyes: no tears, constant rubbing and blinking; sensitivity to light; difficulty seeing clearly;...