... versus15.5% and 15%,respectively).EV71wasassociatedwith47.3%(26/545)ofcasesin2000 and wasthedominantstrainassociatedwithfatalitiesin2001(25/41,61%).Between1998 and 2005,thenumberofsevereHFMD/HAcasesperyearrangedfrom35to405.Ofthe1548severecasesidentifiedduringtheeight-yearperiod,93%werefouryearsofageoryounger, and 75%weretwoyearsofageoryounger.Themale-to-femaleratiowas1.5:1.Atotalof245fatalcaseswerereportedduringthesameperiod.EV71positivityratesamongthefatalcasesrangedfrom11%to100%ineachyear(42-44).Thenumberofseverecases and deaths,respectively,were:11 and 0in2006;12 and 2in2007;373 and 14in2008; and 29 and 2in2009.[ 7 ]A Guide to Clinical Management and Public Health Response for Hand, ... Clinical Management and Public Health Response for Hand, Foot and Mouth Disease (HFMD)transmission; pathogenesis; laboratory diagnosis; clinical features and management; and prevention and control.In ... and accounting for 62.2%to74.5%ofreportedcases.DuringtheEV71-associatedHFMDepidemicinMarch and April2006,1.8%ofthecaseswerehospitalized.ThatratewasmorethantwiceashighasinthoseepidemicscausedbyCA16(betweenMarch and April2005,0.8%ofcaseswerehospitalized, and betweenApril and May2007,0.7%ofcaseswerehospitalized).[ 9 ]A Guide to Clinical Management and Public Health Response for Hand,...