... can be increased by the use of hemodiafiltration, high heparin doses, and filters with a large surface area Key messages • Circuit life span in continuous renal replacement therapy in children ... heparin anticoagulation for continuous renal replacement in critically ill patients Kidney Int 2005, 67:2361-2367 Hackbarth R, Bunchman TE, Chua AN, Somers MJ, Baum M, Symons JM, Brophy PD, Blowey ... reductions during continuous renal replacement therapy and circuit life Intensive Care Med 2004, 30:2074-2079 Holt AW, Bierer P, Bersten AD, Bury LK, Vedig AE: Continuous renal replacement therapy in...