MIS in pediatric solid tumor

báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt

... and to define the upper limit of pore size within the BTB of the respective solid tumors Using this approach, we found that the physiologic upper limit of pore size in the BTB of brain RG-2 gliomas ... over-estimation of the actual physiologic upper limit of pore size within the BTB of peripheral solid tumors Therefore, if the actual physiologic upper limit of pore size within the BTB of peripheral ... extravasation of macromolecules across the endothelial barrier of continuous microvasculature is a result of an increase in the physiologic upper limit of pore size in the barrier due to the disruption of...

Báo cáo y học: "Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors" pps

... observed in of patients with RCC in this study confirmed the efficacy of everolimus in Chinese patients with RCC, consistent with experience from the larger phase III study in RCC [11] At the time of ... al.: Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors Journal of Hematology & Oncology 2011 4:3 ... phase I study was recommended by the China State Food and Drug Administration to evaluate PK, safety, and antitumor activity of oral everolimus and 10 mg/day in Chinese patients with advanced solid...

Báo cáo y học: "A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors Steffen Eikenberry" ppsx

... DOX Interestingly, binding to proteins affects DOX delivery differently in the plasma and extracellular tumor space While increasing the fraction of bound DOX in the plasma inhibits delivery to ... [34,35], and larger tumors have greater IFP everywhere [21] Tumor cord geometry parameters Vessel and cord radii Tumors can vary greatly in the level of perfusion and in the regularity of their ... The modeled tumor system The modeled tumor system The systemic circulation is connected to the primary tumor mass The primary mass is composed of a number of individual tumor cords Doxorubicin delivery...

Chromium speciation in municipal solid waste: Effects of clay amendment and composting

... redistribution of metal speciation during composting by humification of the organic matter Chromium speciation in municipal solid 0 day q 20th waste 21 of cornpasting Cr (w/kg) day of composting Control ... 1) In contrast to the decrease of soluble organic matter during sludge composting, it gradually increased during the composting of MSW although the increment was diminished by the addition of ... role of clay addition in controlling the mobility and plant availability of metals (Qiao et al., 1993) In order to determine the long-term fate and potential hazard of land application of MSW...

Báo cáo y học: "Long Term Persistence of IgE Anti-Influenza Virus Antibodies in Pediatric and Adult Serum Post Vaccination with Influenza Virus Vaccine"

... anti -influenza virus antibodies Serum from subjects with past history of influenza virus vaccination or no infection was incubated with nitrocellulose strips containing influenza virus vaccine ... and elevated in adults and children vaccinated with Influenza virus Children with no history of either Influenza virus infection or vaccination had serum IgE levels which were low (Table 1) Anti -Influenza ... vaccinated pediatric and adult subjects, approaching two years post vaccination The exact role of IgE in Influenza virus infection remains to be elucidated; however, the presence of IgE anti Influenza...

Báo cáo y học: "Matrix Metalloproteinase Activity in Pediatric Acute Lung Injur"

... metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury Hum Pathol 2006; 37:422-430 Hammer J, Numa A, Newth CJ Acute respiratory distress syndrome caused by respiratory syncytial virus ... M, Cleroux P, Tremblay P, et al Increased proteolytic activity and matrix metalloproteinase expression in lungs during infection by porcine reproductive and respiratory syndrome virus J Gen Virol ... for the study included immunosuppresion (recent steroids or cytotoxic therapy), transplantation or failure to obtain study consent Definition of Acute Lung Injury ALI was defined as hypoxemia (ALI...

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

... Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer Cancer Sci 98, ... Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib Cancer Res 66, ... homology in the C-terminal regulatory domain are relatively low, being 33, 24 and 28%, respectively regulin and epigen); (b) those that bind to EGFR and ERBB4 (including betacellulin, heparin-binding...

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

... compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig 1) Early clinical studies showed ... (2006) Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors Genes Dev 20, 1496–1510 ... FEBS I Okamoto EGFR-targeted anticancer therapy Fig In the wild-type EGFR, ligand binding to EGFR leads to receptor dimerization, autophosphorylation and activation of downstream signaling pathways...

Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

... (2006) Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors Genes Dev 20, 1496–1510 ... Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 ... causes apoptosis The T790M mutation of the EGFR, which renders geﬁtinib and erlotinib ineffective inhibitors of EGFR kinase activity, blocks geﬁtinb-induced up-regulation of Bim and apoptosis [38]...

Infliximab therapy in pediatric Crohn’s disease: a review docx

... Unlike infliximab, adalimumab is prescribed as a subcutaneous injection every weeks as a maintenance therapy. 28,29 Infliximab use in children Studies evaluating the safety and efficacy of infliximab ... and in inducing and maintaining remission in patients with active CD ACCENT I was a multicenter randomized double-blind international trial studying retreatment and remission maintenance in adult ... normal after months of discontinuing infliximab. 56 In a study of 6290 adult patients on maintenance infliximab therapy, there was no increased risk of malignancy in the infliximab group compared...

Báo cáo khoa học: Immunonanoparticles ) an effective tool to impair harmful proteolysis in invasive breast tumor cells docx

... obtained from human invasive ductal breast carcinoma Immunohistochemical analysis showed specific staining for breast tumors: positive staining was detected mostly in primary breast carcinomas and ... polymeric nanoparticles, potent protease inhibitor cystatin and a specific anti-cytokeratin monoclonal IgG, which can be internalized into cells, contributes specific targeting to invasive breast epithelial ... Anti-cytokeratin monoclonal IgG-coated nanoparticles, strongly interacting with protein A (B) Noncoated nanoparticles without significant binding (C) Anti-cytokeratin monoclonal IgG nanoparticles, was monitored...

Clinical Findings in Pediatric Respiratory Disorders Kei Lutalo PhD, NRCP docx

... -Kei Lutalo PhD, NRCP Email:klutalo@gmail.com Clinical Findings in Pediatric Respiratory Disorders Submitted in 2005 ... compliance causes an increased work of breathing and the following clinical findings Patient identification Primarily occurs in infants of less than 34 weeks gestational age Chief complaint Respiratory ... occur in more severe cases The clinical findings associated with CF are as follows Patient identification Occurs equally in males and females; predominately in Caucasians; usually diagnosed in childhood...

Báo cáo khoa học: Determining and understanding the control of glycolysis in fast-growth tumor cells Flux control by an over-expressed but strongly product-inhibited hexokinase pdf

... Alterations in the activity and isozymic proﬁle of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation -and progression-linked discriminants of malignancy Cancer ... N-terminal segment [54] Hexokinase- I is predominantly located in brain, kidney, retina and breast, whereas hexokinase- II is abundant in skeletal muscle and adipose tissue [8] In tumor cells, hexokinase- II ... for HeLa cells and other human tumor cell types [46,47] However, before we can conclude that hexokinase is the main controlling step, we should further examine the content and activity of the GluT...

báo cáo hóa học:" TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors" ppt

... protein-protein interactions THD2 consists of one or more PEST signals rich in proline, serine and threonine residues, while THD3 harbors a novel PHD zinc finger- and/ or bromodomain-interacting ... carcinoma TRIP-Br2 is overexpressed in multiple human solid tumors and associated with poor prognosis in hepatocellular carcinoma (HCC) (A) Multiple human tumor tissue arrays were immunostained ... TRIP-Br for binding to PHD zinc finger- and/ or bromodomain-containing proteins, arrests proliferation and induces caspase-3-independent sub-diploidization in cancer cells in vitro [23] In summary,...

Báo cáo hóa học: "Genomic aberrations in borderline ovarian tumors" doc

... feature prominently in both overt carcinomas [37,50] and in the present series (the gains were found in of cases with bilateral borderline tumors and in of informative unilateral tumors showing imbalances) ... calculated in the present series was 18.72 It is interesting to note that for the bilateral borderline ovarian tumors the ANCA index was 24.5 whereas for the unilateral borderline ovarian tumors ... detected by HR-CGH in 11 borderline ovarian tumors Gains are shown in green and losses in red color Micci et al Journal of Translational Medicine 2010, 8:21 http://www.translational-medicine.com/content/8/1/21...

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