Clinical philosophy philosophy as ther
báo cáo khoa học: "Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer" doc
... larger datasets and results of ongoing adjuvant trials are needed to provide confirmatory evidence for or against the concept and feasibility of withdrawal therapy in locally advanced and metastatic ... “withdrawal therapy” as a form of hormonal manipulation for breast cancer World Journal of Surgical Oncology 2011 9:101 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... Segaloff A, Rubens RD: Assessment of response to therapy in advanced breast cancer: a project of the Programme on Clinical Oncology of the International Union Against Cancer, Geneva, Switzerland Cancer...
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Báo cáo y học: "Pain as a symptom of peripheral nerve sheath tumors: clinical significance and future therapeutic directions" potx
... A, Hotta T, Morita T, Yamamura S, Hosaka N, Kobayashi H, Hirata Y: Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis Skeletal radiology ... presenting symptom of peripheral nerve tumors Of clear importance is the ability to differentiate between benign and malignant lesions as early as possible in the clinical work-up and management of these ... cytokines and growth factors [1,16,17] The later two classes of molecules have the particularly appealing characteristic of potentially specific inhibition as a means of alleviating cancer pain...
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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
... consequence of the displacement of bound proteins from the singlestranded overhang, chiefly hPOT1, as well as possible uncapping of telomerase from the ends There are likely to be multiple mechanisms involved, ... such as diethylamine, pyrrolidine or piperidine Structure-based drug discovery does have these few structures as starting points [42–47], although these also indicate that the flexibility of the ... A431 human epithelial carcinoma MDA-MB-231 human breast cancer MIA PaCa-2 human pancreatic cancer UXF1138L human uterine carcinoma M14, LP, LM melanoma RHPS4b CG5 breast carcinoma Quarfloxin Quarfloxin...
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báo cáo hóa học:" A highly invasive human glioblastoma pre-clinical model for testing therapeutics" pot
... Acknowledgements We are grateful to Drs David Wenkert and Yuehai Shen for 17AAG characterization and to Drs Jacob Zhang and Kyle Furge for statistical analysis We thank Michelle Bassett for assistance in ... highly invasive into the brain parenchyma and rarely fully resectable Xenograft mouse models for human GBM inadequately recapitulate the human disease because of slow growth and invasion at the ... test was used for comparison of 17AAG treatments against DBM2 pulmonary metastases Results GBM tumor cells have metastatic potential Primary and metastatic brain tumors are often aggressive and...
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Báo cáo y học: " Androgens as therapy for androgen receptorpositive castration-resistant prostate cancer" ppt
... Intermittent Androgen Deprivation therapy is a strategy to periodically perform and terminate the androgen ablation therapy, therefore patients in “off -androgen ablation therapy periods may decrease ... signaling can be a potential therapy for AR-positive advanced prostate cancer Figure Androgen and alternative therapy for advanced prostate cancer After androgen ablation therapy, androgen treatment will ... deprivation therapies by increasing intracrine androgen synthesis within the prostate [36,37] Androgen Ablation Therapy Androgen ablation therapy, using luteinizing hormonereleasing hormone agonists...
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Báo cáo y học: "Progesterone - new therapy in mild carpal tunnel syndrome? Study design of a randomized clinical trial for local therapy" pptx
... al., Progesterone - new therapy in mild carpal tunnel syndrome? Study design of a randomized clinical trial for local therapy Journal of Brachial Plexus and Peripheral Nerve Injury 2010, 5:11 ... 19:35 7-3 61 52 American Association of Electrodiagnostic Medicine AAoN, and American Academy of Physical Medicine and Rehabilitation: Practice parameter for electrodiagnostic studies in carpal tunnel ... property, in view of his effects on proinflammatory cytokines [41] and prostaglandins [42]; in addition this hormone has demonstrate capability to decrease edema formation after brain injury [43] By...
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Báo cáo khoa học: "Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage" pptx
... reported worsening outcome after discontinuing routine use of albumin to induce hypervolemia in SAH [80] Lumbar drainage of CSF and intracisternal thrombolysis The amount of blood in the subarachnoid ... small randomized placebo-controlled, single-center studies investigated the safety and feasibility of statins in SAH In one study, pravastatin reduced the incidence of TCD-defined vasospasm and ... development of vasospasm is unsettled The risk of vasospasm is increased in the presence of systemic inflammatory response syndrome [27] Furthermore, cerebrospinal fluid (CSF) levels of interleukin-1β and...
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Báo cáo y học: "Cost-effectiveness analysis of clinical specialist outreach as compared to referral system in Ethiopia: an economic evaluation" pot
... patients in the data collection process prior to any attempt to collect data Data analysis Analysis of the cleaned data set was done by using SPSS 16.0 Data from different sources get linked during analysis ... cost effective than referral system in using the time of scarce clinical specialists Changes in project cost and loss of income by voluntary specialists were also found not to change this conclussion ... Voluntary participation of a clinical specialist costing ETB 1.0 and an investment of ETB 3.3 to coordinate voluntary services was found to save ETB 25.9 for pateints and care takers Thus clinical specialist...
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Báo cáo y học: "Clinical review: Balancing the therapeutic, safety, and economic issues underlying effective antipseudomonal carbapenem use" ppt
... supporting the use of the antibiotic, the expected therapeutic benefits and the possibility of resistance, the adverse-event profile, the cost-effectiveness of therapy with the agent, and the appropriate ... infections However, they have a narrow therapeutic window and the need for low-dose therapy to avoid neurotoxicity and the need for high-dose therapy to ensure efficacy and prevent the development of ... initiation of therapy [52] Carbapenem dosing and resistance Resistance to carbapenems probably reflects two major drivers: the 20-year history of widespread use of imipenem and other carbapenems, and dosing...
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Báo cáo y học: "Clinical review: Goal-directed therapy in high risk surgical patients" docx
... debt’, indicating tissue hypoxia, were related to worse outcomes [8,9] Physiologically fitter patients are able to meet this increased oxygen demand by increasing their oxygen delivery, mainly through ... of augmenting oxygen delivery in high- risk surgical patients during the peri-operative period [23] In 1988 Shoemaker and colleagues [8] showed that morbidity and mortality of high- risk patients, ... Effects of maximising oxygen delivery on morbidity and mortality in high- risk surgical patients Crit Care Med 2000, 10:3396-3404 Sinclair S, James S, Singer M: Intraoperative intravascular volume...
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Báo cáo y học: "Clinical review: Oxygen as a signaling molecule" potx
... NF-κB and AP-1 in endothelial cells Am J Physiol 1995, 269(6 Pt 1):L829-L836 50 Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karin M, Kikugawa K: Evidence that reactive oxygen ... electrophiles Free Radic Biol Med 2004, 36:1208-1213 53 Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, Yamamoto M, Nabeshima Y: An Nrf2/small Maf heterodimer ... delayed myocardial preconditioning Ann N Y Acad Sci 2007, 1095:251-261 23 Akamatsu Y, Haga M, Tyagi S, Yamashita K, Graca-Souza AV, Ollinger R, Czismadia E, May GA, Ifedigbo E, Otterbein LE, Bach...
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Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)
... protection pathways in APAP- and H2O2 -induced liver injury in TAMH cells 156 Figure 44 Combination therapy of exosomes and -T3 in APAP- and H2O 2induced liver injury in TAMH cells ... virally -induced disease predominated in early 90s but has substantially declined in the past few years, with most acute injury cases now arising from drug induced- liver injury (DILI) [7] In the ... Chapter Introduction 1.1 Liver injury and its pattern 1.2 Clinical outcomes of drug- induced liver injury 1.3 Mechanism of liver injury 1.3.1 General drug- induced liver...
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
... pancreas The pro -inflammatory cytokines including Tumor necrosis factor- (TNF), Interleukin (IL)-1, IL-6, anti -inflammatory mediators including IL-10, IL-1 receptor antagonist, chemokines including ... IkappaB kinase kinases IL Interleukin JNK c-Jun N-terminal kinases LPS Lipopolysaccharide MAPK Mitogen-activated protein kinases XIV MCP-1 Monocyte chemotactic protein-1 MIP-1a Macrophage inflammatory ... causes a rapid induction of cytokines and chemokines followed by an early decline in mice, while CLP induces a slower sustained increase of cytokines and chemokines in both the plasma and peritoneum,...
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Enzymatic preparation of microbial polyester based novel block copolymers as thermoplastic biomaterials
... ENZYMATIC PREPARATION OF MICROBIAL POLYESTER- BASED NOVEL BLOCK COPOLYMERS AS THERMOPLASTIC BIOMATERIALS DAI SHIYAO (M Eng., Zhejiang University, China) A THESIS SUBMITTED FOR THE DEGREE OF ... Enzymatic Modification of PHB 54 2.3 Candidates for Microbial PHB -based Block Copolymers 55 CHAPTER ENZYMATIC PREPARATION OF NOVEL THERMOPLASTIC DI -BLOCK COPOLYESTERS CONTAINING ... polymerization with PHB-diol as macro-initiator provides a new method for the preparation of PHB -based block copolymers as biomaterials with good thermoplastic properties and novel structures containing...
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MESENCHYMAL STEM CELLS AS THERAPY AGAINST HUMAN GLIOBLASTOMA MULTIFORME
... blue-stained cells over total cells (blue-stained cells + unstained cells) multiplied by 100 2.9 Caspase activity assay Caspase activity was determined using ApoAlert Caspase Colorimetric Assay Kit ... Expression level of caspase also plays a role in determining the sensitivity to TRAIL Increase in caspase degradation, as well as silencing of caspase through methylation, has been reported to ... DISC, caspase is activated through dimerization and cleavage Activated caspase triggers the activation of the downstream effector caspase 3, which leads to subsequent cleavage of caspase substrates...
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