drug streochemitry analytical methods and pharmacology 3rd
Tài liệu DRUG STEREOCHEMISTRY Analytical Methods and F''''hannacology Second Edition_2 ppt
... severaland step series of reactions involvingring opening and amide formation with pyrrolidine,oxidationtothealdehyde,epimerization,reduction ,and ether formation ledto amide [34] Ozonolysis and ... theunexpectedloss of tosylate and aziridine formation Olefin formation from [56] via the N-oxide and chain extensiongaveacid [57J Iodolactonization and tri-n-butyltin hydride reduction in thestandard fashion ... EnantiomericailyPure Drugs 209 H0 108 109 R = CH(CH,)OCH,CH:, R2 SI(CeH&C(CH& HO' H 79 FIGURE Continued 19 the carbonate, protectionof the primaryand secondary hydroxyl groups as a tosylate and ethoxyethyl...
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Tài liệu Analytical Methods: EViews and Panel Data ppt
... refer to variables by the first part name and the question mark Thus, if we type a command using GDP? EViews uses all three GDP series for the USA, Canada, and Mexico Notice the button PoolGenr PoolGenr ... our POOL, we would click PoolGenr and then type the equation: GDPPC? = GDP? / POP? For estimation, EViews has one window in which the user specifies the equation and the assumptions regarding the ... Hypothesis Testing In panel data models (as in single-equation multiple-regression models) we are interested in testing two types of hypotheses: hypotheses about the variances and covariances of...
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Analytical methods for the performance evaluation and improvement of multiple part type manufacturing systems
... topologies of manufacturing systems 2.2 Analytical methods for the performance evaluation of manufacturing systems There has been a plethora of literature on the analytical modeling of production systems ... objective of this thesis is to develop analytical methods to evaluate the performance of multiple part- type production systems The multiple part- type systems that have been studied in the literature ... that were developed for the analysis of single part- type manufacturing systems are first reviewed These methods were often the foundation for the analysis of multiple part- type systems Subsequently,...
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Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
... develop and apply computational methods and tools for ADR and toxicity prediction The methods developed in this work are potentially useful for development and application of QSAR models as well ... complex, time consuming and resource intensive Toxicity is one of the primary reasons for the failure of drug candidates in later stages of drug development Moreover, adverse drug reaction (ADR) during ... drug development and safety assessment 1.2 QSAR studies for ADR and toxicity prediction To deliver promising drug candidates to reach the late stage of drug development with a higher chance of...
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Hair dyes in cosmetic-regulatory aspects and analytical methods
... Colouring Agents in Decorative and other Cosmetics Analytical Methods THE DETERMINATION OF HAIR DYES IN COSMETICS Thus, bearing in mind the above-mentioned observations, it is obvious that the analytical ... (Continued) Page 201 Andrisano et al (1994a) 4EmPD, pMAP, pPD ITP-CD, PTFE capillary tube and KOH/picolinic acid pH 5.4 (containing and -cyclodextrin) and mM acetic acid as leading and terminating ... certain hair dyes and other colouring agents So, US regulations prohibit any cosmetic product to be marketed Ch004.qxd 1/10/2007 2:59 PM Page 197 4.3 Hair Dyes Regulatory Aspects and Analytical Methods...
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Colouring agents in cosmetic products(excluding hair dyes)-regulatory aspects and analytical methods
... certification in a cosmetic renders such product adulterated within the meaning of the FD&C Act DETERMINATION OF COLOURING AGENTS The importance of determining colouring agents in cosmetic products ... the corresponding straight colouring agents Japan regulatory requirements for colouring agents in cosmetic products In Japan, colouring agents are named as colorants As mentioned in Section 1.2, ... 2:59 PM 154 Page 154 Colouring Agents in Decorative and other Cosmetics Analytical Methods Table 4.2.1 Number of colouring agents permitted for use in cosmetics by the three main regulatory authorities...
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Glycoprotein Methods and Protocols - P1
... different methods are available: solution assays such as colorimetric assays for hexose and sialic acid; membrane-based methods such as slot-blotting and staining with periodic acid-Schiff reagent; ... on-line with a UV monitor and collect fractions using a fraction collector and subject to the appropriate carbohydrate and antibody analyses 3.6 Analysis of Mucins Methods for the detection and ... remaining tissue From: Methods in Molecular Biology, Vol 125: Glycoprotein Methods and Protocols: The Mucins Edited by: A Corfield © Humana Press Inc., Totowa, NJ Davies and Carlstedt To isolate...
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Glycoprotein Methods and Protocols - P2
... to T-antigen (β-d-Gal 1-3 GalNAc), but also to structures found within the backbone of oligosaccharides (β-d-Gal 1-3 / 4GlcNAc) (19) Demonstration of PNA binding is not necessarily evidence of T-antigen ... W., Coret, E., Trueman, L., and Clay, M G (1984) Histochemical identification of side chain substituted O-acetylated sialic acids: the PATKOH-Bh-PAS and the PAPT-KOH-Bh-PAS procedures Histochem ... mounting, and its relative stability There are, however, several other alternatives, such as 3-amino9-ethylcarbazole (AEC), for use with horseradish peroxidase (HRP); 5-bromo-4-chloro3-indolyl...
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Glycoprotein Methods and Protocols - P3
... gel-forming mucins, in Glycoprotein Methods and Protocols: The Mucins (Corfield, T., ed.), Humana, Totowa, NJ Carraway, K L (2000) Preparation of membrane mucin, in Glycoprotein Methods and Protocols: The ... chromogens that leave a colored precipitate on the blot (e.g., 3,3'-diaminobenzidine, 4-chloronapthol mix for HRP [14]; 5-bromo-4-chloro-3'-indolyphosphate toluidine salt, nitro blue tetrazolium chloride ... Histologically-based methods for detection of mucin, in Glycoprotein Methods and Protocols: The Mucins (Corfield, T., ed.), Humana, Totowa, NJ Davies, R., Carlstedt, I (2000) Isolation of large gel-forming...
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Glycoprotein Methods and Protocols - P4
... phenol in 70 mL of glycerol Poly-L-lysine-coated slides: slides are immersed in 0.01% (w/v) poly-L-lysine for and dried at room temperature Methods 3.1 Observation and Measurement of Mucous Thickness ... adherent to rat, frog and human gastric mucosa: influence of feeding prostaglandin, N-acetyl-cysteine and other agents Clin Sci 63, 187–195 Bell, A E., Allen, A., Morris, E R., and Ross-Murphy, S B (1984) ... structure and carbohydrate side-chains in gel-formation Carbohydrate Res 178, 93–110 Sellers, L A., Allen, A., Morris, E., and Ross-Murphy, S B (1991) The rheology of pig small intestinal and colonic...
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Glycoprotein Methods and Protocols - P5
... [35S]sulfate-labeled, TCA-precipitable proteins in tissue homogenate (j1) and medium (j2) (cpm/mL) (Note 10) k Mature [35S]sulfate-labeled mucin band in tissue homogenate (k1) and medium (k2) on 4% SDS-PAGE ... interest in the homogenate and medium by Western-type dot-blot procedure Spot aliquots of the homogenates or media on nitrocellulose paper, using the dot-blot apparatus and air-dry for Perform all ... PhosphorImager The identification of mucin precursors and mature mucins using polypeptide-specific antisera and SDS-PAGE is elaborated in Chapters 20 and 21, and in several references (1,4–11) The precursor...
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Glycoprotein Methods and Protocols - P6
... monitored with a periodic acid-Schiff (PAS) assay and with a variety of lectins and mucin- or carbohydrate-specific antibodies (for a discussion of the relative merits and drawbacks of these analytical ... gel, use 1.6 g of agarose and 160 mL of buffer, and for a large gel, use 2.8 g of agarose and 280 mL of buffer Leave to cool before pouring (hand hot) and insert well-forming comb (see Note 2) ... reduced subunits prepared from the gel-forming mucins isolated from other epithelial secretions (respiratory and cervical) and from intestinal cell lines (HT-29 and PC/AA) In this example the electrophoretic...
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