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Lecture Connections 17 | Fatty Acid Catabolism

Lecture Connections 17 | Fatty Acid Catabolism

Lecture Connections 17 | Fatty Acid Catabolism

... anaerobic catabolism of fats Fatty Acids are Converted into Fatty Acyl-CoA Fatty Acid Transport into Mitochondria • Fats are degraded into fatty acids and glycerol in the cytoplasm • -oxidation of fatty ... Sources of ATP Oxidation of Monounsaturated Fatty Acids Oxidation of Polyunsaturated Fatty Acids Oxidation of Propionyl-CoA • Most dietary fatty acids are even-numbered • Many plants and some ... Associated with inner mitochondrial membrane • Processes fatty acid chains with 12 or more carbons; shorter ones by enzymes in the matrix Fatty Acid Catabolism for Energy • Repeating the above four-step...
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Fatty acid catabolism leture2 3

Fatty acid catabolism leture2 3

... chain fatty acids diffuse into peroxisomes, get acivated by long chain fatty acylCoA synthase and then they are oxidized to short chain FA Omega-oxidation: This is a rare pathway of fatty acid ... This is followed by isomerization reaction and βoxidation What about odd-chain fatty acids; In case of odd-chain fatty acylCoA, a three carbon unit , the propionyl-CoA is left at the last cycle ... mitochondria, the fatty acyl CoA is subjected to beta oxidation Utilization of FA for oxidation and generation of ATP is achieved in the following three steps; beta-oxidation of fatty acid chain yielding...
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Chapter 24 fatty acid catabolism

Chapter 24 fatty acid catabolism

... • 24. 1 Mobilization of Fats from Dietary Intake and Adipose Tissue • 24. 2 Beta-Oxidation of Fatty Acids • 24. 3 Odd-Carbon Fatty Acids • 24. 4 Unsaturated Fatty Acids • 24. 5 Other Aspects of Fatty ... Fatty Acids • 24. 5 Other Aspects of Fatty Acid Oxidation • 24. 6 Ketone Bodies Why Fatty Acids? (For energy storage?) • Two reasons: – The carbon in fatty acids (mostly CH2) is almost completely ... lipases Pancreatic lipases cleave fatty acids at the C-1 and C-3 positions Resulting monoacylglycerols with fatty acids at C-2 are hydrolyzed by intestinal lipases Fatty acids and monoacylglycerols...
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Lecture Connections 16 | The Citric Acid Cycle

Lecture Connections 16 | The Citric Acid Cycle

... CHAPTER 16 The Citric Acid Cycle Key topics: – Cellular respiration – Conversion of pyruvate to activated acetate – Reactions of the citric acid cycle – Regulation of the citric acid cycle – ... prosthetic groups are strongly bound to the protein In this case, the lipoic acid is covalently linked to the enzyme via a lysine residue The Citric Acid Cycle Sequence of Events in the Citric Acid ... Eukaryotes, Citric Acid Cycle Occurs in Mitochondria • Glycolysis occurs in the cytoplasm • Citric acid cycle occurs in the mitochondrial matrix† • Oxidative phosphorylation occurs in the inner...
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FATTY ACID COMPOSITION INCLUDING TRANS FATTY ACIDS CONTENT OF SELECTED VIETNAMESE INSTANT NOODLES

FATTY ACID COMPOSITION INCLUDING TRANS FATTY ACIDS CONTENT OF SELECTED VIETNAMESE INSTANT NOODLES

... polyunsaturated fatty acids * MUFA: monounsaturated fatty acids * TFA: trans fatty acids * tc: traceal 818 Fatty acid composition including trans fatty acids content of selected Vietnamese instant noodles Trans ... abundant fatty acid in all samples; its concentration was from 39% to 42% (total fatty Fatty acid composition including trans fatty acids content of selected Vietnamese instant noodles Table Fatty acid ... composition including trans fatty acids content of selected Vietnamese instant noodles Table1 Fatty acids composition of selected Vietnamese Instant noodles Fatty acid C14:0 Brands IN1 IN2 IN3 IN4...
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Characterization of the Carbon Stable Isotope Ratio and Fatty Acid Structure of Zostera japonica in Coastal Areas

Characterization of the Carbon Stable Isotope Ratio and Fatty Acid Structure of Zostera japonica in Coastal Areas

... acid structure in Z japonica We found about 30 kinds of fatty acids in the leaves and stems and about 36 kinds of fatty acids in the roots and rhizomes of Z japonica We focused on the fatty acid ... based on the quantity of lipid, the content ratios of all the fatty acids, and the ratio of each fatty acid RESULTS AND DISCUSSION Characteristics of carbon stable isotope in Z japonica The mean ... dominant fatty acids and Fig shows the dominant fatty acids in the leaves and stems of Z japonica in each sampling site The term “other” in the x-axis designates the sum of all the fatty acids with...
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Effect of unsaturated fatty acid esters of biodiesel fuels on combustion, performance and emission characteristics of a DI diesel engine

Effect of unsaturated fatty acid esters of biodiesel fuels on combustion, performance and emission characteristics of a DI diesel engine

... investigating the relationship between percentage of unsaturation, maximum heat release rate and peak pressure for karanjia biodiesel Biodiesel of karanjia has a lower percentage of unsaturation and ... relatively higher in mahua biodiesel than that of biodiesel of palm In addition to unsaturation, ignition delay increases with fuel density and iodine value The effect of unsaturation on ignition ... and exhaust gas temperature was observed in case of high unsaturated biodiesel Heat release rate and cumulative heat release rate is lower in case of high- unsaturated biodiesel fuel A general...
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THÀNH PHẦN hợp CHẤT AXÍT béo và CAROTENOID của gấc   fatty acid and carotenoid composition of gac (momordica cochinchinensisspreng) fruit

THÀNH PHẦN hợp CHẤT AXÍT béo và CAROTENOID của gấc fatty acid and carotenoid composition of gac (momordica cochinchinensisspreng) fruit

... Fatty Acid and Carotenoids in Gac Fruit MATERIALS AND METHODS Fatty Acid Analysis Materials Gac fruit were purchased from two Asian markets (Vinh Phat and Shun Fat) in Sacramento, ... almost half of the weight of the entire fruit Fatty Acid Analysis Data on total FAME content of aril from two gac fruit were collected Total % weight content of FAME in these two fruit was nearly ... ) standard deviation, % d RSD ) relative standard deviation, % vaccenic (in two fruit) , R-linolenic, and eicosa-11-eneoic acids were also detected The fatty acid composition of the aril and seed...
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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

... exposure of liver cells to FFAs Interruption of TAG synthesis in conditions of excess availability of SFAs is the key point in the molecular mechanism of SFA-induced lipotoxicity It is suggested ... constitutes the initiating event in the process of lipotoxicity Stearate has to be activated in order to be toxic The first enzyme involved in metabolism of FFAs after their uptake into liver cells is the ... (16:0) into the TAG pool only in the presence of oleate [18] The above results raise two main questions: (a) what is the cause of TAG synthesis inhibition, and (b) what is the exact nature of the events...
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Tài liệu Báo cáo khoa học: Fatty acid synthesis Role of active site histidines and lysine in Cys-His-His-type b-ketoacyl-acyl carrier protein synthases ppt

Tài liệu Báo cáo khoa học: Fatty acid synthesis Role of active site histidines and lysine in Cys-His-His-type b-ketoacyl-acyl carrier protein synthases ppt

... model of the ligand-binding potential of the active site, enabling differentiation between the active site properties of target enzymes to be made This study probes the roles of the active site histidines ... Histidines and lysine in KAS I ⁄ KAS II catalysis P von Wettstein-Knowles et al Scheme group because of the cysteine and two histidine activesite residues [1–3] Another group of decarboxylating ... co-ordinated in the vicinity of the active site (Fig 2) Three of the six cation ligands are main-chain oxygen atoms, and three are the side-chain oxygen atoms of N296, E342 and S387 The glutamic acid...
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Tài liệu Báo cáo khoa học: Fatty acid desaturases from the microalga Thalassiosira pseudonana pptx

Tài liệu Báo cáo khoa học: Fatty acid desaturases from the microalga Thalassiosira pseudonana pptx

... Pavlova lutheri [15], Ostreococcus tauri and Thalassiosira pseudonana [16] These novel fatty acid elongases were used to successfully reconstitute DHA synthesis in yeast Therefore, all the activities ... comprehensive study on the T pseudonana front-end desaturases demonstrates the value of whole genome sequence for gene discovery programmes Whether the complete set of PUFA desaturases from T pseudonana ... Identification of a fatty acid A11-desaturase from the microalga Thalassiosira pseudonana FEBS Lett 563, 28–34 19 Sperling P, Ternes P, Zank TK & Heinz E (2003) The evolution of desaturases Prostaglandins...
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Báo cáo khoa học: Peptides from purified soybean b-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain pot

Báo cáo khoa học: Peptides from purified soybean b-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain pot

... et al b-conglycinin peptides inhibit fatty acid synthase A B C Fig Detailed 2D interactions between inhibitors and the thioestherase (TE) domain Calculated using the MOE program following the method ... b-conglycinin peptides inhibit fatty acid synthase the interdomain regions were excluded because they could not be accounted for with the single domain structures The volumes of each of the identified ... Table Molecular docking within the fatty acid synthase (FAS) potential binding site and human FAS thioesterase (TE) inhibitory potency (IC50) of soybean b-conglycinin- derived peptides, C75 and Orlistat...
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Báo cáo khoa học: Mutants of Saccharomyces cerevisiae deficient in acyl-CoA synthetases secrete fatty acids due to interrupted fatty acid recycling docx

Báo cáo khoa học: Mutants of Saccharomyces cerevisiae deficient in acyl-CoA synthetases secrete fatty acids due to interrupted fatty acid recycling docx

... certain pools of fatty acids To assess the role of acyl-CoA synthetases in regulating particular pools of fatty acids, we used mutants of S cerevisiae characterized by various combinations of deletions ... exogenous fatty acids, additional release of internal fatty acids had to contribute to the increase of intracellular fatty acids However, analysis of the previously mentioned fatty acid specificity of ... (square)] (D) Concentration of fatty acids in the pools of free fatty acids in the media (diamonds), of free fatty acids in the cells (square) and of esterified fatty acids (triangle) The error...
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Báo cáo khoa học: Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio) pptx

Báo cáo khoa học: Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio) pptx

... Spatio-temporal distribution of cellular retinol-binding protein gene transcripts (CRBPI and CRBPII) in the developing and adult zebrafish (Danio rerio) Eur J Biochem 271, 339–348 Ohmachi T, Inoue ... Alves-Costa et al The zebrafish fabp6 gene Distribution of fabp6 gene transcripts in zebrafish embryos and larvae Fig A neighbor-joining tree showing the phylogenetic relationship of zebrafish Fabp6 with selected ... the AB strain of zebrafish (see http://zfin.org for strain details) The zebrafish fabp6 gene The coding sequence of the fabp6 gene contained an open reading frame of 393 bp (not including the stop...
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Báo cáo khoa học: Functional characterization of front-end desaturases from trypanosomatids depicts the first polyunsaturated fatty acid biosynthetic pathway from a parasitic protozoan ppt

Báo cáo khoa học: Functional characterization of front-end desaturases from trypanosomatids depicts the first polyunsaturated fatty acid biosynthetic pathway from a parasitic protozoan ppt

... Pavlova lutheri (AAQ98793), Thraustochytrium sp (AAN75710), Thalassiosira pseudonana (AAX14506); D5 desaturases from Caenorhabditis elegans (AAC95143), Mortierella alpina (AAC72755), Phaeodactylum ... gracilis It is reasonably clear from the analysis of this branch that D5 desaturases in nematodes and vertebrates may have diverged from an ancestral D6 desaturase in each of these lineages after ... C22 and then desaturated by a D4 desaturase to the same final 22:5 n-6 and 22:6 n-3 PUFAs Euglena exhibits another variation in the first steps of the pathway C18 FAs are elongated to C20, and then...
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