... provided evidence of the interplay of r factors and their interaction with regulators, how exactly these factors coordinate with one another in the face of an adverse event, and the order of events, ... replication in the lung during the short-term infection of mice [109,110], the negative regulation of their synthesis by rM negates the possibility of its role in virulence during the early course of infection ... in the sigG mutant The aforementioned result is expected in view of the downregulation of sigH and the upregulation of sigD upon the deletion of sigG in M tuberculosis [90] This finding further...