... in terms of elasticity coefficients In this contribution, we develop a completely general modular elasticity analysis of large metabolic responses, for the case of two modules and one intermediate, ... i i The rates of the supply and demand modules, vi, are w non zero and therefore the coefficients Cvi are always well defined One of the central aims of the present work is to w show how the coefficients ... The control analysis for large changes presented in this work is, in our view, a completely general analysis for the case of two modules and one linking intermediate Its limitations in the application...