... neutrophils Infect Immun 2000, 68:4792-4794 doi: 10.1186/cc9025 Cite this article as: Mankhambo et al., The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian ... fundamental role in the maintenance of vessel integrity Angiopoietin-1 (Ang-1) and Ang-2 are ligands of the endothelial receptor tyrosine kinase Tie-2, which is a key regulator of endothelial function ... production of growth factors, with increased CSF concentrations in nonsurvivors VEGF, PDGF, FGF, Ang-1, and Ang-2 may be key players in the endothelial dysregulation seen in severe bacterial infection, ...