... discovery of a brain- specific MT isoform, GIF, in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularly within the injured or diseased brain In the ... studies examining the role of GIF in AD, linked to its initial discovery as a factor deficient in the AD brain There remains no clear consensus on the role of GIF in the pathogenesis of AD, and therefore ... FEBS 2935 Function of GIF in injured and degenerative brain C Howells et al transection of mature neurons [31] However, in the absence of brain extract (either AD or from the normal brain) GIF...