... analysis and interpretation of data, manuscript preparation, and statistical analysis SKT participated in acquisition of data, analysis and interpretation of data, and manuscript preparation SC participated ... data, manuscript preparation, and statistical analysis J-PP participated in study design, analysis and interpretation of data, and manuscript preparation JM-P participated in study design, analysis ... morphological changes that appear to be part of the OA process These changes are allied with many local abnormal biochemical pathways, including the increased synthesis of several bone markers,...