... Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation -and progression-linked discriminants of malignancy Cancer ... N-terminal segment [54] Hexokinase- I is predominantly located in brain, kidney, retina and breast, whereas hexokinase- II is abundant in skeletal muscle and adipose tissue [8] In tumor cells, hexokinase- II ... for HeLa cells and other human tumor cell types [46,47] However, before we can conclude that hexokinase is the main controlling step, we should further examine the content and activity of the GluT...