The regulatory role of mixed lineage kinase 4 beta in MAPK signaling and ovarian cancer cell invasion

... without the expressed permission of the author An Abstract of The Regulatory Role of Mixed Lineage Kinase Beta in MAPK Signaling and Ovarian Cancer Cell Invasion by Widian F Abi Saab Submitted to the ... .Leucine zipper KSR Kinase suppressor of ras MAPK Mitogen activated protein kinase MAPKAP-K .MAPK- activated protein kinase MAP2K MAPK kinase MAP3K MAPK kinase kinase MEK MAPK/ ERK kinase ... entitled The Regulatory Role of Mixed Lineage Kinase Beta in MAPK Signaling and Ovarian Cancer Cell Invasion by Widian F Abi Saab Submitted to the Graduate Faculty as partial fulfillment of the requirements...

THE REGULATORY ROLE OF MATRIX METALLOPROTEINASES IN T CELL ACTIVATION

... These enzymes are in an inactive state due to the thiol (SH-) group of the cysteine residue within the pro-domain interacting with the Zn2+ ion in the catalytic domain Disruption of this cysteine-zinc ... receptor Thy1.1 Thymus cell antigen 1, theta Thy1.2 Thymus cell antigen 2, theta TIMP Tissue inhibitor of matrix metalloproteinases TGF-β Transforming Growth Factor beta Th1 T helper xxv Th2 T helper ... for the cell surface activation of pro-MMP-2 by MT-MMP1 (29) E Matrix metalloproteinases and cytokine modulation Apart from digesting the ECM, the gelatinases modulate the activity of other proteases...

Báo cáo khoa học: "the Role of Non-Timber Forest Products (NTFPs) in Livelihood Strategies and Household Economies in a Remote Upland Village in the Upper Ca River Basin, Nghe An, Vietnam" pdf

... have an accurate view about the livelihood strategies, household economies and role of NTFPs in a poor mountain community with poor access to markets in the upper Ca River Basin, and allow them ... field/capita, number of livestock, cash income from NTFP collection, and cash income from wage labor The focus of this analysis was on the natural capital of households, as farmers in Tha Lang hamlet ... other strategies The Role of Non-Timber Forest Products (NTFPs) in Livelihood Strategies Table Characteristics of Livelihood Strategies Strategy Indicator Swidden area/capita (m2) Cattle: Households...

báo cáo hóa học:" Trends in the clinical characteristics of HIVinfected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009" pdf

... characteristics of patients accessing ART during this phase of the scale up in east Africa Methods Patients The EA-IeDEA is a cohort of patients from clinical care sites in Uganda, Kenya and Tanzania ... comprised a decreasing fraction of new patients accessing ART in Kenya, dropping from 41% in 2002- 03 to 34% in 2008-09 (p < 0.01), but the fraction of men accessing care in Uganda and Tanzania did ... were from Uganda, and 4119 (9%) were from Tanzania Of 35 sites, 28 were in Kenya, four in Uganda and three in Tanzania Overall, 1118 (2%) patients started ART in 2002- 03, 12, 875 (27%) in 2004-05,...

Báo cáo khoa hoc:" Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms" ppsx

... absolute levels of sCTLA-4 protein and SNP genotypes Our data confirm and extend the findings of Purohit and co-workers [30], who reported a lack of association between CT60 genotype and sCTLA-4 levels ... for sCTLA-4 in blood plasma for the purpose of determining whether there was an association with common SNPs within the CTLA-4 and ICOS regions of human chromosome 2q33 No evidence of an association ... comparing positive vs negative blood levels of sCTLA-4 Thus, our data not support a relationship between these commonly tested SNPS and circulating levels of sCTLA-4 in the presence or absence of...

Báo cáo y học: "The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix" pptx

... part of the CDK's cyclin D2 binding domain Its rotation during the activation of CDK4 is required to unblock the catalytic cleft of the kinase [44 ] Binding of Tax to this region may influence its ... experiments were quantitated They revealed a 3.5 – fold increased protein binding of TaxM1R40 to CDK4 and cyclin D2 compared to the cyclin E control (Figure 1D) The binding to CDK4 of the N-terminal peptide ... Retrovirology 2005, 2: 54 http://www.retrovirology.com/content/2/1/ 54 Figure Binding of the isolated Tax N-terminus to CDK4 and cyclin D2 Binding of the isolated Tax N-terminus to CDK4 and cyclin D2...

Tài liệu Báo cáo khoa học: Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase fromThermus thermophilus pdf

... N-terminal regions of the a-subunits serves as catalytic domains, and the C-terminal regions of the a-subunits and the b-subunits act as regulatory domains [10,11] The regulatory domains of AK contain ... ª 2009 The Authors Journal compilation ª 2009 FEBS 3131 Crystal structures of regulatory subunit of Thr-sensitive aspartate kinase Potential factors involved in the high thermostability of TtAKb ... 2009 The Authors Journal compilation ª 2009 FEBS A Yoshida et al Crystal structures of regulatory subunit of Thr-sensitive aspartate kinase Table Thermostabilization factors Comparison of the...

Tài liệu Báo cáo Y học: CK2btes gene encodes a testis-speciﬁc isoform of the regulatory subunit of casein kinase 2 in Drosophila melanogaster potx

... catalytic activity of a subunit toward calmodulin and for the activation by polybasic compounds The examination of amino-acid alignment in the acidic region of three Drosophila CK2 regulatory subunits ... coimmunoprecipitated with CK2 a subunit in Drosophila testes extracts Fig Analysis of oligomerization status of the CK 2a and CK2btes proteins by gel ﬁltration The CK 2a and CK2btes proteins alone or in the ... reasonable to suppose a possibility of a replacement of one b subunit by another in the case of a deﬁciency of any of the subunits, i.e a so called ÔbypassÕ mechanism may operate in order to maintain...

Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

... raise the possibility that GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin ... Effects of insulin, Li and SB-415286 on signalling elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and SB-415286 on cell signalling events we assessed their ... by insulin Regulation of GS activity To establish the importance of GSK3 inhibition on GS activity we monitored the effects of insulin, Li, SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation...

Báo cáo khoa học: Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions Comparison with the role of phosphotidylinositol-3 kinase ppt

... counteracts the calcineurin induced affinity switch of a5b1 integrin in CHO cells, suggesting also a role for Ca2+/calmodulin- dependent molecules in regulating the affinity state of integrins on neutrophils ... Ca2+/calmodulin- dependent kinases in human neutrophils Increased [Ca2+]i is sufficient to regulate multiple intracellular signaling pathways Therefore, the role of calmodulin, the major downstream effector ... 6A,B) Therefore chemoattractant induced activation of PtdIns3K and elevation of [Ca2+]i are in themselves insufficient in the protection of neutrophils against apoptosis DISCUSSION In this study, the...

Báo cáo Y học: The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei docx

... consistently coprecipitated a protein kinase activity exhibiting many characteristics of the catalytic subunit of trypanosomal PKA The coprecipitated kinase is recognized by an antibody against the ... demonstrated the presence of a PKA-like kinase activity in T cruzi [29] The current study describes the identiﬁcation and characterization of the regulatory subunit of trypanosomal PKA (TbRSU) Many of ... antibody against the catalytic subunit of bovine PKA In these experiments, the antibody detected a protein with a Mr of about 40 000, suggesting that the catalytic subunit of trypanosomal PKA does...

Báo cáo y học: "4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase" doc

... articular chondrocytes and as the main precursor for the synthesis of ECM glycosaminoglycans in cartilage [35,36] The inhibition of proteoglycan synthesis in OA chondrocytes by HNE (data not shown) ... goal of clarifying this role, we documented the ability of HNE to modulate markers of apoptosis, redox status, and energy metabolism of chondrocytes Then, we investigated the potential role of the ... augmented the cytotoxic effect of HNE as determined by MTT assay In contrast, the overexpression of this enzyme in chondrocytes offered significant protection against HNE-induced cell cytotoxicity These...

Cyclic stretch enhances the expression of Toll-like Receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-B pathway doc

... siRNA inhibited the induction of TLR4 protein by cyclic stretch The NF-B binding activity and TLR4 promoter activity induced by cyclic stretch were attenuated by p38 inhibitor, indicating p38 MAP ... because the specific and potent inhibitors of an upstream p38 kinase, SB203580 inhibited the induction of TLR4 protein This signaling pathway of p38 was further confirmed by the finding that p38 ... al.: Cyclic stretch enhances the expression of Toll-like Receptor gene in cultured cardiomyocytes via p38 MAP kinase and NF-B pathway Journal of Biomedical Science 2010 17:15 • No space constraints...

Báo cáo y học: "Statistical assessment of the global regulatory role of histone acetylation in Saccharomyces cerevisia" potx

... complex [9-11] Histone tails can be modified in various ways, including acetylation, methylation, phosphorylation, and ubiquitination Even the regulatory role of histone acetylation, the best characterized ... and H4 acetylations have different regulatory roles [17-20] We investigated the validity of a cumulative model for the regulatory effect of histone acetylation and also compare the regulatory effects ... to the cutoff threshold for removing ambiguous genes As a quantitative validation of the above observation, we reexamined the validity of equation in modeling the regulatory role of histone acetylation...

THE ROLE OF PYRUVATE DEHYDROGENASE KINASE IN GLUCOSE AND KETONE BODY METABOLISM

... Davis, and Oun Kheav iv ABSTRACT Yasmeen Rahimi THE ROLE OF PYRUVATE DEHYDROGENASE KINASE IN GLUCOSE AND KETONE BODY METABOLISM The expression of pyruvate dehydrogenase kinase (PDK) and are increased ... on the other hand, inhibits Akt/protein kinase B [41] Both of these lipid derivatives turn off the insulin signaling cascade and prevent insulin stimulated glucose uptake, resulting in less glucose ... favors the acetylations of the reduced lipoyl moieties of E2 The reduced and acetylated lipoyl moieties of E2 subunit attract the binding of the PDKs and ensure maximum kinase activity, resulting in...

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